67 macrocyclic molecules have been approved by the FDA as commercial drugs. Macrocyclization is a widely used strategy to improve potency and selectivity, enhance permeability, and elevate metabolic stability under physiological conditions. Bifunctional linear mono- and diamines serve as excellent linkers for macrocyclization, with the incorporation of cyclic elements and fluorine atoms enabling fine-tuning of conformation and acid-base properties towards an improved pharmacological profile. Explore our collection of fluorinated amine linkers for your next project!
Case study
Download SD file
Download PDF file
We offer
Over 100 fluorinated amine linkers from stock on 5-10 gram scale.
