67 macrocyclic molecules have been approved by the FDA as commercial drugs. Macrocyclization is a widely used strategy to improve potency and selectivity, enhance permeability, and elevate metabolic stability under physiological conditions. Bifunctional linear mono- and diamines serve as excellent linkers for macrocyclization, with the incorporation of cyclic elements and fluorine atoms enabling fine-tuning of conformation and acid-base properties towards an improved pharmacological profile. Explore our collection of fluorinated amine linkers for your next project!
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Over 100 fluorinated amine linkers from stock on 5-10 gram scale.