Introduced in 2016 as reagents for the synthesis of cyclobutyl amines and thiols, bicyclobutanes have emerged as excellent precursors for organic transformations as well as substituents in medicinal molecules. The compounds are bench-stable materials, however, the intrinsic strain of the bicyclic skeleton makes them reactive in nucleophilic addition, cycloaddition, and insertion reactions. In biological settings, bicyclobutanes are particularly reactive towards cysteine residues, creating an alternative to maleimide for covalent binding. Following the rising demand for their use in organic reactions, Enamine chemists have prepared a library of bicyclobutanes for exploring innovative chemical reactions.

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Over 20 bicyclobutanes from stock on 5-10 gram scale.


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