Bifunctional Heterocyclic Scaffolds

Bis-halogenated heterocycles have proven to be useful precursors for the selective synthesis of functionalized pharmaceutical molecules. Herein, we offer a library of building blocks with two chlorine atoms bearing different reactivity. The chloro-chloromethyl heterocyclic compounds are great starting materials amenable to two sequential aminations: the chloromethyl moiety reacts first via a traditional nucleophilic substitution, while the remaining active chlorine reacts afterwards in S_NAr substitution (uncatalyzed) or Buchwald–Hartwig amination (Pd-catalyzed). Try our heterocyclic scaffolds in your research!