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Analogues of Piperidine for Drug Design

More than 70 FDA-approved drugs contain the piperidine moiety. Piperidine-based analogues may advantageously alter important pharmacokinetic properties such as lipophilicity and metabolic stability when grafted onto molecular scaffolds. Synthetic strategies for setting new spirocyclic, fused and bridged sp3-rich scaffolds are in high demand in the medicinal chemistry community. Herein, we have designed and synthesized a library of piperidine analogues for drug design.

Design

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>100 unique piperidine analogues on a 5-50 g scale from stock.

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