Sulfonyl fluorides (-SO2F)
Sulfonyl chlorides (-SO2Cl) are widely used in medicinal chemistry and agrochemistry as precursors to pharmacologically important sulfonamides. Many sulfonyl chlorides with heteroaromatic substituents, however, are unstable due to SO2 extrusion. More stable sulfonyl fluorides (-SO2F) in many cases are the only option to synthesize the desired sulfonamides. They are less reactive, so that they might even have a free aliphatic amino groups in their structure. Besides unique monofunctional sulfonyl fluorides, Enamine offers a wide array of scaffolds and linker compounds.
The fluoride rescues the lead:

- Stable to moisture
- Improved selectivity
- Orthogonal reactivity to many other functional groups
- Scaffolds
-SO2F probes in chemical biology

The SO2F group covalently binds to the residues of serine, threonine, tyrosine, lysine, cysteine, and histidine in proteins. Sulfonyl fluorides are widely used as chemical probes and covalent protein inhibitors.
Our offer:
>200 Sulfonyl fluorides (-SO2F) in gram amounts in stock. Custom synthesis of further analogues and compound libraries.
MedChem Highlights
- Boron-containing heterocyclic scaffolds with active halogens
- Aliphatic Pinacol Boronates for Medicinal Chemistry
- Deuterium-Containing Building Blocks for Drug Design
- Analogues of Piperidine for Drug Design
- SnAP Reagents
- Fluoroalkyl ethers for Drug Design
- N-Nitrosamines
- N-Trifluoromethyl Azoles for Drug Discovery
- Cyclic sulfates and sulfamidates as alkylating reagents
- Saturated Bioisosteres for ortho-substituted Benzenes
- Aliphatic Trifluoroborates (-BF3) for C-C couplings
- Functionalized Vinyl Boronates for C-C couplings
- Unique 3D-shaped Spirocycles
- Water-soluble non-classical benzene mimics
- gem-Difluorinated Amines for Drug Design
- Fluorosulfates and Sulfamoyl Fluorides
- Alkyne-containing Linkers
- Structurally optimized tetrazines for rapid biological labeling
- Building blocks and linkers for PROTAC synthesis
- Heterocyclic Sulfonyl Fluorides
- Silicon-Containing Building Blocks
- Epoxides for Drug Design
- Analogues of CF3-Pyridine for Drug Design
- Piperazine Bioisosteres for Drug Design
- Sugar-like Building Blocks for Drug Design
- Cyclic Sulfonamides for Drug Design
- Morpholine Bioisosteres for Drug Design
- P(O)Me2-containing Building Blocks
- Saturated Bioisosteres of ortho-/meta-substituted Benzenes
- Saturated bioisosteres of para-substituted benzenes
- Sulfonyl fluorides (-SO2F)
- Diazirines
- Oxetane-containing Building Blocks
- SF5-Building Blocks
- Stannanes for coupling reactions
- Sulfoximines for Drug Design
- Heterocyclic scaffolds
- Azide-linkers for Drug Design
- Unnatural Amino Acids
- Cubanes for Medicinal Chemistry
- Benzoxaboroles for Drug Design