Ladderanes for Medicinal Chemistry

Ladderanes occur naturally in the lipids of anaerobic ammonium-oxidizing bacteria. Their potential in medicinal chemistry was only recently realized. Mono-substituted ladderane serves as an excellent 3D-shaped scaffold, occupying a molecular volume close to that of morpholine ([2]-ladderane) or azepane ([3]-ladderane). Disubstituted ladderanes demonstrate an isosteric relationship with ortho- and meta-substituted aromatics, showing remarkably close geometric resemblance. Our team of chemists has prepared a series of unique ladderanes and their heterocyclic analogs for exploring their potential in medicinal chemistry.

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Over 20 ladderanes from stock on 5-10 gram scale.


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