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  • An Efficient Approach To Novel Tetrahydropyridoazepines. Expansion Of Azepines’ Drug-like Chemical Space

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  • Synthesis of Gem-difluorocyclobutane/pentane/hexane Building Blocks – Useful Reagent For Drug Discovery

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  • Ruppert – Prakash reagent as a difluorocarbene synthetic equivalent for the synthesis of medchem-relevant building blocks

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  • Cyclobutane ring as a conformational restriction tool

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  • Novel spirocyclic and fused cyclopropane scaffolds for medicinal chemistry

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  • Saturated Bioisosteres of Benzene with Improved Solubility

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  • Cubanes for Drug Design

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  • CH-Activation of L-Proline analogues

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  • Application of AI to REAL Space: A Step Ahead to Expand the Synthetically Feasible Chemical Space

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  • Conformationally-rigid pyrrolidines with improved water solubility

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  • Aminosulfonyl fluorides for drug design

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  • Difluorocyclopropanes for drug discovery

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  • Novel spirocycles for drug discovery

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  • Bicyclic amines for drug discovery by [2+2]-photocyclization

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  • 1,3-Oxazoles and 1,2,4-oxadiazoles as selective agonists of GPR40 receptor

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  • Design and synthesis of novel 3D-shaped building blocks to “Escape the Flatland”

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  • Proline analogues: advanced building blocks for drug design

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  • New synthetic approach to diverse heterocyclic sulfonyl chlorides

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  • Conformationally restricted scaffolds by Double-Mannich reaction of cyclic ketones

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  • Synthesis of unique pyrrolidines for drug discovery

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  • Design and synthesis of morpholine analogues

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  • Novel fluorinated amines for drug discovery

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  • CF 3CHN 2and C 2F 5CHN 2: highly underestimated reagents

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