Dr. Oleksandr Grygorenko shares his time as Principal Scientist at Enamine Ltd. and Associate Professor (Docent) at National Taras Shevchenko University of Kyiv.

His blog posts are mostly related to organic and medicinal chemistry.

New Building Blocks For Drug Discovery Are Getting Closer: Gem-difluorocyclopropane-derived Amines

Artwork by Web Design Studio "ZORELiT"

(This article originally appeared at


Modern drug discovery relies heavily on the ability of chemists to produce good starting points for producing high-quality lead compounds. Several concepts were established in the last two decades to aim synthetic organic chemistry onto the proper areas of chemical space, in particular, the so-called lead-oriented approach which describes paradigm shift towards low-molecular-weight, relatively hydrophilic, conformationally restricted, sp3-enriched structures.

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