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Dear Customers,

Since our return to the labs 1 month ago, we have managed to restore and catch up with practically all our synthesis and stock operations. We are extremely grateful for your being with us during these difficult times. We were happy to receive your messages of strong support and orders, demonstrating your continuous trust in Enamine. It means a lot to all of us, and it helped our quick rebirth.

Drug discovery is a long and challenging process, which may take up to fifteen years of experimentation and clinical trials, and several billion dollars in various expenses to bring a successful drug to patients. The process can be roughly divided into three stages: 1) biology research and early drug discovery; 2) preclinical drug development; and 3) clinical trials.

In order to start a drug discovery program, at the first stage, scientists study biological processes to come up with proper understanding of the underlying causes of a particular disease. Once drivers of the disease are known, scientists can select specific biological targets -- typically proteins involved in a disease-causing biological process.

We are happy to inform you that we have successfully completed the relocation of our entire collection of screening compounds and started weighing compound samples since yesterday. All 3.5 million vials with dry compounds have been safely moved to our new facility in Sokal, a town near Lviv with a population of 20 000 people in the West of Ukraine, close to the Polish border.

I decided to write this post because I needed to share my feelings for the last 56 days. Of course, I did not experience as much as those who were in the hot areas or took the arms to defend Ukraine, but possibly my personal story might still be interesting to the readers (sorry for the long read with a little bit too much personal touch).

Dear Customers,

As of today, 17 countries among which France, Italy, and Austria to name a few, along with the European Union have sent their diplomats back to Kyiv, reopening their embassies, a vote of confidence that the Russia’s assault against the Ukrainian capital city and its region is over. This important symbolic and solidarity step from our allies makes clear that the necessary safety in Kyiv is returning, while the Russians have decided to re-focus on the East of Ukraine.

From our side, we are continuing working at full throttle to contribute to restoring our beloved homeland and its economy. Over 350 chemists including 100 FTE’s in our clients’ research projects have been able to resume their programs in our laboratories in Kyiv. We appreciate tremendously your indefatigable support, commitment, and trust in us!

This week we are happy to announce that our compound management team has resumed the liquid handling replication of our compound libraries. Although some more time (2 weeks) is required to fully re-start the weighing of dry compound samples from our screening collection, we can already supply from our liquid stock various pre-plated compound libraries. In line with our last week’s announcement, our very first dry-ice shipment since nearly two months has just left Kyiv towards our logistics centre in Riga from where individual orders will be further distributed to multiple clients across the world.

We are also pleased to confirm that our biology department Bienta has fully resumed its operations and provision of integrated drug discovery support. All our research facilities and technical equipment are in perfect working condition. Currently, all our groups and units (high throughput screening, bioanalytical, mass spectrometry, and in vivo) are resuming their projects and are ready to start new ones. The in vivo group is restoring the population of its laboratory animals, which were saved in our in-house core breeding section thanks to our galvanized colleagues’ efforts.

For further details, please send inquiries to This email address is being protected from spambots. You need JavaScript enabled to view it..

Faithfully Yours,
Enamine Team

Dear Customers,

In the last 10 days there have been no missile strikes on Kyiv and normal life settles down in the capital. Last week we reported on resuming operations with our main building block warehouse in Ukraine and today we are pleased to inform you that we are going to start delivering your orders for screening compounds since the middle of April. In the meantime, we are completing transfer of the entire stock of screening compounds to our new facility in the west of Ukraine, near the Polish border.

Enamine’s screening collection has over 3 million small molecular weight compounds and is the largest and most reputable commercial collection in the world. We are happy to continue providing our compounds for drug discovery worldwide!

Another good news is that we have resumed synthesis of REAL Compounds, re-opening access to over 20 billion new compounds. Very soon we will be starting to deliver your important hit-finding and hit exploration libraries synthesized in our labs.

Not everything can now be as smooth and fast as it used to be. We are still working on improving synthesis and delivery times. Unfortunately, we cannot absorb any longer the excessive production costs that have significantly increased over the last few years because of the inflation, increase in the prices of the raw materials, etc. After implementation of the contingency plan, we have to increase the prices, unchanged for 2 years, for both off-the-shelf screening compounds and REAL Compounds. Thank you for your understanding and support in this difficult time!

We remain committed to serving the world’s drug discovery and look forward to receiving your new inquiries and orders.

Yours faithfully,
Enamine Team

We, at Enamine, have united to resist at our level the Russian invasion. We help to acquire non-lethal military aid to enhance the defense of Ukraine, provide medical supplies to the hospitals, provide sponsorship for science and education in Ukraine, and help our employees scattered by war across Ukraine and abroad. Our own funds are limited as we have had to put on hold most of our projects and we will greatly appreciate your donations, which we will immediately use for the urgent needs of today! This is the most direct help to Ukraine.

Dear Customers, Dear Colleagues, Dear Friends,

The war in our country lasts more than 10 days. We have put on hold most of our operations in Kyiv and ask our customers to wait until this situation is resolved. We thank all of you for your patience. During this time, we have been able to estimate our resources, capabilities, and plan next steps to be done. Now I would like to highlight some of them:

Russian aggression continues with more force and they continue killing civilians (at least 200 killed only today officially, and who knows how many more). Enamine is forced to adjust schedules of operations, please, support our fight for our lives.

As I already wrote in my previous post , we at Enamine are constantly working on extending our REAL concept (where REAL is for REadily AccessibLe compounds). Basically, this concept allows for the generation of a virtual chemical space based on the experimentally validated synthetic accessibility. Until now the REAL Space has comprised 15.5 billion make-on-demand molecules and is currently the largest offer of commercially available compounds. It was shown that this chemical space is especially useful in combination with high-throughput virtual screening techniques (see Nature 2019, 566, 224–229 and Nature 2020, 580, 663–668 ); there is also a number of other ways to access it.

Dear Friends,

On February 24, Russian army attacked Ukraine at the full scale of its military potential, and started the bloodiest war in the European continent since WWII. As it is unfolding, more and more shocking crimes are committed by Russian forces against Ukrainian civilians. What happened in the cities of Irpen and Bucha shocked not only Ukrainians, but the whole civilized world.

The launch of Enamine Charity Fund was the practical answer by our team to the increasing crisis in Ukraine, and we are thankful to everyone who contributed money to help us provide help to our fellow Ukrainians, including our colleagues and friends in Irpen and Bucha.