Publications

Design and Synthesis of a Monofluoro-Substituted Aromatic Amino Acid as a Conformationally Restricted ¹⁹F NMR Label for Membrane-Bound Peptides

Eur. J. Org. Chem. 2014, 17, 3584-3591

DOI: 10.1002/ejoc.201301737

Tkachenko A. N.; Mykhailiuk P. K.; Radchenko D. S.; Babii O.; Afonin S.; Ulrich A. S.; Komarov I. V.

How Accurately Can We Predict the Melting Points of Drug-like Compounds?

J. Chem. Inf. Model. , 2014, 54 (12), 3320-3329

DOI: 10.1021/ci5005288

Tetko I. V.; Sushko Y.; Novotarskyi S.; Patiny L.; Kondratov I.; Petrenko A. E.; Charochkina L.; Asiri A. M.

Control of Regio- and Enantioselectivity in the Asymmetric Organocatalytic Addition of Acetone to 4-(Trifluoromethyl)pyrimidin-2(1H)-ones

Eur. J. Org. Chem. , 2014, (7), 1452-1460

DOI: 10.1002/ejoc.201301542

Sukach V. A.; Tkachuk V. M.; Shoba V. M.; Pirozhenko V. V.; Rusanov E. B.; Chekotilo A. A.; Röschenthaler G. V.; Vovk M. V.

One-Pot Synthesis of CF₃-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF₃CHN₂ Generated in situ: Optimized Synthesis of Tris(trifluoromethyl)pyrazole

Eur. J. Org. Chem. , 2014, 12, 2487-2495

DOI: 10.1002/ejoc.201301852

Slobodyanyuk E. Y.; Artamonov O. S.; Shishkin O. V.; Mykhailiuk P. K.

Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core

Eur. J. Med. Chem. , 2014, 84 160-172

DOI: 10.1016/j.ejmech.2014.07.023

Sarnpitak P.; Mujumdar P.; Morisseau C.; Hwang S. H.; Hammock B.; Iurchenko V.; Zozulya S.; Gavalas A.; Geronikaki A.; Ivanenkov Y.; Krasavin M.

Toward Lead-Oriented Synthesis: One-Pot Version of Castagnoli Condensation with Nonactivated Alicyclic Anhydrides

ACS Comb. Sci. , 2014, 16 (3), 146-153

DOI: 10.1021/co4001277

Ryabukhin S. V.; Panov D. M.; Granat D. S.; Ostapchuk E. N.; Kryvoruchko D. V.; Grygorenko O. O.

Three-Component Synthesis of 4-Aroyl-2(1),4,5,7-Tetrahydropyrazolo[3,4-b]Pyridin-6-Ones and Their Properties

Chem. Heterocycl. Compd. , 2014, 50 (4), 514‑527

DOI: 10.1007/s10593-014-1502-7

Petrova O. N.; Zamigajlo L. L.; Gella I. M.; Musatov V. I.; Shishkina S. V.; Shishkin O. V.; Vashchenko E. V.; Borisov A. V.; Lipson V. V.

Generation of C₂F₅CHN₂ In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes

Chem. Eur. J. , 2014, 20 (17), 4942-4947

DOI: 10.1002/chem.201304840

Mykhailiuk P. K.

Synthesis of Thieno[2,3-d]imidazoles by Copper-Catalyzed Amidine Cyclization

Synlett , 2014, 25 (07), 965-968

DOI: 10.1055/s-0033-1340959

Liubchak K.; Tolmachev A.; Nazarenko K.

Enzymatic resolution of chroman-4-ol and its core analogues with Burkholderia cepacia lipase

Tetrahedron: Asymmetry , 2014, 25 (67), 563‑567

DOI: 10.1016/j.tetasy.2014.02.010

Kucher O. V.; Kolodyazhnaya A. O.; Smolii O. B.; Boiko A. I.; Kubyshkin V. S.; Mykhailiuk P. K.; Tolmachev A. A.

Enzyme-Catalyzed Kinetic Resolution of 2,2,2-Trifluoro-1-(heteroaryl)ethanols: Experimental and Docking Studies

Eur. J. Org. Chem. , 2014, 34, 7692-7698

DOI: 10.1002/ejoc.201403013

Kucher O. V.; Kolodiazhnaya A. O.; Smolii O. B.; Prisuazhnyk D. V.; Tolmacheva K. A.; Zaporozhets O. A.; Moroz Y. S.; Mykhailiuk P. K.; Tolmachev A. A.

Role of Protein Phosphatase 1 in Dephosphorylation of Ebola Virus VP30 Protein and Its Targeting for the Inhibition of Viral Transcription

J. Biol. Chem. , 2014, 289 (33), 22723-22738

DOI: 10.1074/jbc.M114.575050

Ilinykh P. A.; Tigabu B.; Ivanov A.; Ammosova T.; Obukhov Y.; Garron T.; Kumari N.; Kovalskyy D.; Platonov M. O.; Naumchik V. S.; Freiberg A. N.; Nekhai S.; Bukreyev A.

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity

Eur. J. Med. Chem. , 2014, 85 245-254

DOI: 10.1016/j.ejmech.2014.07.103

Havrylyuk D.; Zimenkovsky B.; Karpenko O.; Grellier P.; Lesyk R.

Conformational behavior of peptides containing residues of 3-azetidinesulfonic (3AzeS) and 4-piperidinemethanesulfonic (4PiMS) acids

Tetrahedron: Asymmetry , 2014, 25 (3), 229‑237

DOI: 10.1016/j.tetasy.2013.12.001

Grygorenko O. O.; Zhersh S.; Oliinyk B. V.; Shishkin O. V.; Tolmachev A. A.

Synthesis and Functionalization of 3-Azolylquinoxalin-2(1H)-ones

Synthesis , 2014, 46 (11), 1487-1492

DOI: 10.1055/s-0033-1340983

Geraschenko O. V.; Khodakovskiy P. V.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.

Structure Analysis and Conformational Transitions of the Cell Penetrating Peptide Transportan 10 in the Membrane-Bound State

PLoS ONE , 2014, 9 (6), e99653

DOI: 10.1371/journal.pone.0099653

Fanghänel S.; Wadhwani P.; Strandberg E.; Verdurmen W. P. R.; Bürck J.; Ehni S.; Mykhailiuk P. K.; Afonin S.; Gerthsen D.; Komarov I. V.; Brock R.; Ulrich A. S.

Conformationally restricted glutamic acid analogues: stereoisomers of 1-aminospiro[3.3]heptane-1,6-dicarboxylic acid

RSC Adv. , 2014, 4 (21), 10894-10902

DOI: 10.1039/C3RA47725H

Chernykh A. V.; Radchenko D. S.; Grygorenko O. O.; Volochnyuk D. M.; Shishkina S. V.; Shishkin O. V.; Komarov I. V.

One-Pot Parallel Synthesis Approach to Secondary Amines Based on the Reductive Amination of Ketones

Synthesis , 2014, 46 (13), 1765-1772

DOI: 10.1055/s-0033-1341226

Bogolubsky A. V.; Moroz Y. S.; Pipko S. E.; Panov D. M.; Konovets A. I.; Doroschuk R.; Tolmachev A.

Sulfonyl Fluorides as Alternative to Sulfonyl Chlorides in Parallel Synthesis of Aliphatic Sulfonamides

ACS Comb. Sci. , 2014, 16 (4), 192-197

DOI: 10.1021/co400164z

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Pipko S. E.; Konovets A. I.; Sadkova I. V.; Tolmachev A.

A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

ACS Comb. Sci. , 2014, 16 (8), 375-380

DOI: 10.1021/co5000568

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Panov D. M.; Pipko S. E.; Konovets A. I.; Tolmachev A.

Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

ACS Comb. Sci. , 2014, 16 (6), 303-308

DOI: 10.1021/co500025f

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Granat D. S.; Pipko S. E.; Konovets A. I.; Doroschuk R.; Tolmachev A.

Controlling Biological Activity with Light: Diarylethene-Containing Cyclic Peptidomimetics

Angew. Chem. Int. Ed. , 2014, 53 (13), 3392‑3395

DOI: 10.1002/anie.201310019

er S.; Mykhailiuk P. K.; Kubyshkin V. S.; Steinbrecher T.; Ulrich A. S.; Komarov I. V.

Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery

Eur. J. Org. Chem. , 2014, 17, 3592-3598

DOI: 10.1002/ejoc.201402158

Artamonov O. S.; Slobodyanyuk E. Y.; Volochnyuk D. M.; Komarov I. V.; Tolmachev A. A.; Mykhailiuk P. K.

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription

Br. J. Pharmacol. , 2014, 171 (22), 5059-5075

DOI: 10.1111/bph.12863

ren A.; Kovalskyy D.; Nekhai S.

Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines

Eur. J. Org. Chem. , 2013, 15, 3086-3093

DOI: 10.1002/ejoc.201300121

Yarmolchuk V. S.; Shishkin O. V.; Starova V. S.; Zaporozhets O. A.; Kravchuk O.; Zozulya S.; Komarov I. V.; Mykhailiuk P. K.

An approach to dihydroisoindolobenzodiazepinones—three-dimensional molecular frameworks

Tetrahedron Lett. , 2013, 54 (10), 1195-1197

DOI: 10.1016/j.tetlet.2012.12.065

Yaremenko A. G.; Shelyakin V. V.; Volochnyuk D. M.; Rusanov E. B.; Grygorenko O. O.

Stereochemical effects on the aggregation and biological properties of the fibril-forming peptide [KIGAKI]₃ in membranes

Phys. Chem. Chem. Phys. , 2013, 15 (23), 8962-8971

DOI: 10.1039/C3CP50896J

Wadhwani P.; Reichert J.; Strandberg E.; Burck J.; Misiewicz J.; Afonin S.; Heidenreich N.; Fanghanel S.; Mykhailiuk P. K.; Komarov I. V.; Ulrich A. S.

Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State ¹⁹F NMR Spectroscopy

Angew. Chem. Int. Ed. , 2013, 52 (25), 6504-6507

DOI: 10.1002/anie.201301344

Tkachenko A. N.; Radchenko D. S.; Mykhailiuk P. K.; Afonin S.; Ulrich A. S.; Komarov I. V.

A ¹⁹F NMR Label to Substitute Polar Amino Acids in Peptides: A CF₃-Substituted Analogue of Serine and Threonine

Angew. Chem. Int. Ed. , 2013, 52 (5), 1486-1489

DOI: 10.1002/anie.201208069

Tkachenko A. N.; Mykhailiuk P. K.; Afonin S.; Radchenko D. S.; Kubyshkin V. S.; Ulrich A. S.; Komarov I. V.

Development of Dimethyl Sulfoxide Solubility Models Using 163 000 Molecules: Using a Domain Applicability Metric to Select More Reliable Predictions

J. Chem. Inf. Model. , 2013, 53 (8), 1990-2000

DOI: 10.1021/ci400213d

Tetko I. V.; Novotarskyi S.; Sushko I.; Ivanov V.; Petrenko A. E.; Dieden R.; Lebon F.; Mathieu B.

Synthesis of New Pyrazolo[1,5-a]pyrimidines by Reaction of β,γ-Unsaturated γ-Alkoxy-α-keto Esters with N-Unsubstituted 5-Aminopyrazoles

Synthesis , 2013, 45 (07), 925-930

DOI: 10.1055/s-0032-1318329

Stepaniuk O. O.; Matviienko V. O.; Kondratov I. S.; Vitruk I. V.; Tolmachev A. O.

Synthesis of 2- and 3-trifluoromethylmorpholines: useful building blocks for drug discovery

Tetrahedron , 2013, 69 (19), 3796-3804

DOI: 10.1016/j.tet.2013.03.067

Shcherbatiuk A. V.; Shyshlyk O. S.; Yarmoliuk D. V.; Shishkin O. V.; Shishkina S. V.; Starova V. S.; Zaporozhets O. A.; Zozulya S.; Moriev R.; Kravchuk O.; Manoilenko O.; Tolmachev A. A.; Mykhailiuk P. K.

Confining the χ space of basic natural amino acids: cyclobutane-derived χ1,χ2-constrained analogues of arginine, lysine and ornithine

Tetrahedron , 2013, 69 (2), 505-511

DOI: 10.1016/j.tet.2012.11.032

Radchenko D. S.; Michurin O. M.; Grygorenko O. O.; Scheinpflug K.; Dathe M.; Komarov I. V.

An easy synthesis of α-trifluoromethyl-amines from aldehydes or ketones using the Ruppert-Prakash reagent

Tetrahedron Lett. , 2013, 54 (14), 1897-1898

DOI: 10.1016/j.tetlet.2013.01.132

Radchenko D. S.; Michurin O. M.; Chernykh A. V.; Lukin O.; Mykhailiuk P. K.

Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics , 2013, 1834 (10), 2170-2175

DOI: 10.1016/j.bbapap.2012.11.011

Petrenko A. G.; Zozulya S. A.; Deyev I. E.; Eladari D.

Protecting Group Free Synthesis of Carboxyl-substituted Dihydropyrimidines Through Biginelli Reaction

J. Heterocycl. Chem. , 2013, 50 (6), 1299-1303

DOI: 10.1002/jhet.1568

Ostapchuk E. N.; Plaskon A. S.; Grygorenko O. O.; Tolmachev A. A.; Ryabukhin S. V.

An Efficient Synthesis of 1-Methyl-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine and Its N⁶-Substituted Analogues

Synthesis , 2013, 45 (07), 919-924

DOI: 10.1055/s-0032-1318346

Nechayev M. A.; Gorobets N. Y.; Kovalenko S. M.; Tolmachev A. A.

1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization

Tetrahedron , 2013, 69 (20), 4066-4075

DOI: 10.1016/j.tet.2013.03.072

Mykhailiuk P. K.; Starova V.; Iurchenko V.; Shishkina S. V.; Shishkin O. V.; Khilchevskyi O.; Zaporozhets O.

Identification of Novel IGF1R Kinase Inhibitors by Molecular Modeling and High-Throughput Screening

Acta Naturae , 2013, 5 (2), 90-99

DOI: PMC3695357

Moriev R.; Vasylchenko O.; Platonov M.; Grygorenko O.; Volkova K.; Zozulya S.

Incorporation of labile trans-4,5-difluoromethanoproline into a peptide as a stable label for ¹⁹F NMR structure analysis

J. Fluorine Chem. , 2013, 152 136-143

DOI: 10.1016/j.jfluchem.2013.03.002

Kubyshkin V. S.; Mykhailiuk P. K.; Afonin S.; Grage S. L.; Komarov I. V.; Ulrich A. S.

Synthesis and Anticancer Activity of 2-(Alkyl-, Alkaryl-, Aryl-, Hetaryl-)-[1,2,4]triazolo[1,5-c]quinazolines

Scientia pharmaceutica , 2013, 81 (2), 359-391

DOI: 10.3797/scipharm.1211-08

Kovalenko S. I.; Antypenko L. M.; Bilyi A. K.; Kholodnyak S. V.; Karpenko O. V.; Antypenko O. M.; Mykhaylova N. S.; Los T. I.; Kolomoets O. S.

A Convenient Route to 1-Alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic Acids Employing a Diazo Transfer Reaction

Eur. J. Org. Chem. , 2013, 14, 2891-2897

DOI: 10.1002/ejoc.201300030

Iminov R. T.; Mashkov A. V.; Chalyk B. A.; Mykhailiuk P. K.; Tverdokhlebov A. V.; Tolmachev A. A.; Volovenko Y. M.; Shishkin O. V.; Shishkina S. V.

Design, synthesis and transformation of some heteroannulated 3-aminopyridines-purine isosteres with exocyclic nitrogen atom

Tetrahedron , 2013, 69 (3), 1217-1228

DOI: 10.1016/j.tet.2012.11.026

Iaroshenko V. O.; Vilches-Herrera M.; Gevorgyan A.; Mkrtchyan S.; Arakelyan K.; Ostrovskyi D.; Abbasi M. S. A.; Supe L.; Hakobyan A.; Villinger A.; Volochnyuk D. M.; Tolmachev A.