Angew. Chem. Int. Ed. 2019, 58 (8), 2454-2458
DOI: 10.1002/anie.201814524
Chen T.; Zhang H.; Mykhailiuk P.; Merchant R.; Smith C.; Qin T.; Baran P.
This work bridges a gap in the cross-coupling of aliphatic redox-active esters with aryl zinc reagents. Previously limited to primary, secondary, and specialized tertiary centers, a new protocol has been devised to enable the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method is broad, and it can be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers.
