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Synthesis and Anticancer Activity of 2-(Alkyl-, Alkaryl-, Aryl-, Hetaryl-)-[1,2,4]triazolo[1,5-c]quinazolines

Scientia pharmaceutica , 2013, 81 (2), 359-391

DOI: 10.3797/scipharm.1211-08

Kovalenko S. I.; Antypenko L. M.; Bilyi A. K.; Kholodnyak S. V.; Karpenko O. V.; Antypenko O. M.; Mykhaylova N. S.; Los T. I.; Kolomoets O. S.

A Convenient Route to 1-Alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic Acids Employing a Diazo Transfer Reaction

Eur. J. Org. Chem. , 2013, 14, 2891-2897

DOI: 10.1002/ejoc.201300030

Iminov R. T.; Mashkov A. V.; Chalyk B. A.; Mykhailiuk P. K.; Tverdokhlebov A. V.; Tolmachev A. A.; Volovenko Y. M.; Shishkin O. V.; Shishkina S. V.

Design, synthesis and transformation of some heteroannulated 3-aminopyridines-purine isosteres with exocyclic nitrogen atom

Tetrahedron , 2013, 69 (3), 1217-1228

DOI: 10.1016/j.tet.2012.11.026

Iaroshenko V. O.; Vilches-Herrera M.; Gevorgyan A.; Mkrtchyan S.; Arakelyan K.; Ostrovskyi D.; Abbasi M. S. A.; Supe L.; Hakobyan A.; Villinger A.; Volochnyuk D. M.; Tolmachev A.

Efficient synthesis of novel thieno[3,2-b]-, [2,3-c]- and [3,2-c]pyridones by Sonogashira coupling of bromothiophenes with terminal alkynes and subsequent intramolecular C–N bond-forming reaction

Tetrahedron , 2013, 69 (15), 3167-3181

DOI: 10.1016/j.tet.2013.02.069

Iaroshenko V. O.; Ali S.; Babar T. M.; Abbasi M. S. A.; Sosnovskikh V. Y.; Villinger A.; Tolmachev A.; Langer P.

Conformational behaviour of peptides containing a 2-pyrrolidinemethanesulfonic acid (2PyMS) residue

Org. Biomol. Chem. , 2013, 11 (6), 975-983

DOI: 10.1039/C2OB27058G

Grygorenko O. O.; Zhersh S.; Oliinyk B. V.; Shishkin O. V.; Tolmachev A. A.

Synthesis and reactivity of 5-polyfluoroalkyl-5-deazaalloxazines

Org. Biomol. Chem. , 2013, 11 (32), 5351-5361

DOI: 10.1039/C3OB26837C

Dudkin S.; Iaroshenko V. O.; Sosnovskikh V. Y.; Tolmachev A. A.; Villinger A.; Langer P.

Unexpected result in the reaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of 1,3-dicarbonyl compounds. synthesis of pyrimidine-5-carboxamide derivatives

Chem. Heterocycl. Compd. , 2013, 49 (3), 440-451

DOI: 10.1007/s10593-013-1266-5

Dotsenko V. V.; Frolov K. A.; Krivokolysko S. G.; Polovinko V. V.

A Noncatalytic Approach to Hetaryl-Annulated 1,2,4-Thiadiazine-1,1-dioxides

J. Heterocycl. Chem. , 2013, 50 (5), 1071-1077

DOI: 10.1002/jhet.1029

Cherepakha A.; Kovtunenko V. O.; Tolmachev A.; Lukin O.

A facile synthesis of annulated azolo[c][1,2,4]thiadiazine S,S-dioxides

Tetrahedron Lett. , 2013, 54 (8), 986-988

DOI: 10.1016/j.tetlet.2012.12.040

Cherepakha A.; Kovtunenko V. O.; Tolmachev A.

Synthesis of imidazo[1,2-a]pyrazine and imidazo[1,2-a]pyrimidine derivatives

Chem. Heterocycl. Compd. , 2013, 49 (5), 704-711

DOI: 10.1007/s10593-013-1301-6

I. A.; Kovalenko S. N.

A solution-phase parallel synthesis of alkylated guanidines from thioisocyanates and amines

Mol. Diver. , 2013, 17 (3), 471-477

DOI: 10.1007/s11030-013-9444-z

Bogolubsky A. V.; Grishchenko A.; Pipko S. E.; Konovets A.; Chuprina A.; Tolmachev A.; Boyko A. N.; Chekotylo A.; Lukin O.

Synthesis of Isomeric 6-Trifluoromethyl-3-azabicyclo[3.1.0]hexanes: Conformationally Restricted Analogues of 4-Trifluoromethylpiperidine

Synthesis , 2013, 45 (02), 225-230

DOI: 10.1055/s-0032-1316831

Artamonov O. S.; Slobodyanyuk E. Y.; Shishkin O. V.; Komarov I. V.; Mykhailiuk P. K.

Synthesis of substituted 4-aminothieno[2,3-d]-, 4-aminothieno[3,2-d]- and 4-aminothieno[3,4-d]pyrimidines

Chem. Heterocycl. Compd. , 2012, 48 (7), 1028-1032

DOI: 10.1007/s10593-012-1095-y

Zadorozhny A. V.

An Efficient and Safe Method for the Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropylamine

Synthesis , 2012, 44 (08), 1152-1154

DOI: 10.1055/s-0031-1289711

Yarmolchuk V. S.; Bezdudny A. V.; Tolmacheva N. A.; Lukin O.; Boyko A. N.; Chekotylo A.; Tolmachev A. A.; Mykhailiuk P. K.

1-Alkyl-5-((di)alkylamino) Tetrazoles: Building Blocks for Peptide Surrogates

J. Org. Chem. , 2012, 77 (2), 1174-1180

DOI: 10.1021/jo2022235

Tymtsunik A. V.; Bilenko V. A.; Kokhan S. O.; Grygorenko O. O.; Volochnyuk D. M.; Komarov I. V.

Synthesis of a novel Boc-protected cyclopropane-modified proline analogue

Tetrahedron Lett. , 2012, 53 (30), 3847-3849

DOI: 10.1016/j.tetlet.2012.05.020

Tymtsunik A. V.; Bilenko V. A.; Ivon Y. M.; Grygorenko O. O.; Komarov I. V.

A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines

Synthesis , 2012, 44 (13), 1974-1976

DOI: 10.1055/s-0031-1290295

Trofymchuk S.; Bezdudny A. V.; Pustovit Y. M.; Lukin O.; Boyko A. N.; Chekotylo A.; Tolmachev A. A.; Mykhailiuk P. K.

Exploiting the Addition of Trimethyl(trifluoromethyl)silane to Functionalized N-Benzylimines for the Preparation of Two Novel x-Trifluoromethyl x-Amino Acids

Synthesis , 2012, 44 (06), 903-908

DOI: 10.1055/s-0031-1289702

Tkachenko A. N.; Radchenko D. S.; Mykhailiuk P. K.; Shishkin O. V.; Tolmachev A. A.; Komarov I. V.

Regioselective Reactions of Ethyl (4,5-Dihydrofuran-3-yl)-2-oxoacetate and Ethyl 2-(3,4-Dihydro-2H-pyran-6-yl)-2-oxoacetate with 1-Unsubstituted Aminoazoles

Synthesis , 2012, 44 (06), 895-902

DOI: 10.1055/s-0031-1289733

Stepaniuk O. O.; Matvienko V. O.; Kondratov I. S.; Shishkin O. V.; Volochnyuk D. M.; Mykhailiuk P. K.; Tolmachev A. A.

A Convenient Synthesis of (1H-Azol-1-yl)piperidines

Synthesis , 2012, 44 (13), 2041-2048

DOI: 10.1055/s-0031-1291126

Shevchuk N. V.; Liubchak K.; Nazarenko K. G.; Yurchenko A. A.; Volochnyuk D. M.; Grygorenko O. O.; Tolmachev A. A.

Approach to the Library of 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones through a Three-Component Condensation

ACS Comb. Sci. , 2012, 14 (12), 631-635

DOI: 10.1021/co300082t

Ryabukhin S. V.; Panov D. M.; Plaskon A. S.; Grygorenko O. O.

Chlorotrimethylsilane-Promoted Condensation of Ketones and Aminoazoles

J. Heterocycl. Chem. , 2012, 49 (5), 1147-1150

DOI: 10.1002/jhet.972

Ryabukhin S. V.; Naumchik V. S.; Grygorenko O. O.; Tolmachev A. A.

High Throughput Synthesis of Extended Pyrazolo[3,4-d]dihydropyrimidines

ACS Comb. Sci. , 2012, 14 (8), 465-470

DOI: 10.1021/co300063x

Ryabukhin S. V.; Granat D. S.; Plaskon A. S.; Shivanyuk A. N.; Tolmachev A. A.; Volovenko Y. M.

Application of chlorotrimethylsilane in Pictet–Spengler reaction

Monatshefte f ,r Chemie - Chemical Monthly 2012, 143 (11), 1507-1517

DOI: 10.1007/s00706-012-0804-7

Ryabukhin S.; Panov D.; Plaskon A.; Tolmachev A.; Smaliy R.

Combinatorial synthesis of chemical building blocks 1. Azomethines

Mol. Diver. , 2012, 16 (4), 625-637

DOI: 10.1007/s11030-012-9407-9

Ryabukhin S.; Panov D.; Plaskon A.; Chuprina A.; Pipko S.; Tolmachev A.; Shivanyuk A.

Recyclizations of 3-formylchromones with binucleophiles

Tetrahedron , 2012, 68 (13), 2743-2757

DOI: 10.1016/j.tet.2012.01.077

Plaskon A. S.; Grygorenko O. O.; Ryabukhin S. V.

The synthesis of low molecular weight pyrrolo[2,3-c]pyridine-7-one scaffold

Mol. Diver. , 2012, 16 (4), 749-757

DOI: 10.1007/s11030-012-9410-1

Nechayev M.; Gorobets N.; Borisov A.; Kovalenko S.; Tolmachev A.

Synthesis of dihydro-2H-pyran-3(4H)-one

Arkivoc , 2012, 8, 226-230

DOI: 10.3998/ark.5550190.0013.820

Mityuk A. P.; Denisenko A. V.; Grygorenko O. O.; Tolmachev A. A.

Direct synthesis of N-phosphanyl-heterocyclic carbenes

Tetrahedron Lett. , 2012, 53 (5), 494-496

DOI: 10.1016/j.tetlet.2011.11.054

Marchenko A. P.; Koidan H. N.; Pervak I. I.; Huryeva A. N.; Zarudnitskii E. V.; Tolmachev A. A.; Kostyuk A. N.

An approach to alicyclic ring-fused xanthines

Tetrahedron , 2012, 68 (41), 8564-8571

DOI: 10.1016/j.tet.2012.08.014

Liubchak K.; Tolmachev A.; Grygorenko O. O.; Nazarenko K.

Additions and Corrections: Incorporation of cis- and trans-4,5-Difluoromethanoprolines into Polypeptides

Org. Lett. , 2012, 14 (22), 5811-5811

DOI: 10.1021/ol3029466

Kubyshkin V. S.; Mykhailiuk P. K.; Afonin S.; Ulrich A. S.; Komarov I. V.

Incorporation of cis- and trans-4,5-Difluoromethanoprolines into Polypeptides

Org. Lett. , 2012, 14 (20), 5254-5257

DOI: 10.1021/ol302412a

Kubyshkin V. S.; Mykhailiuk P. K.; Afonin S.; Ulrich A. S.; Komarov I. V.

Synthesis of condensed tetrahydroimidazo[1,2-a]quinazoline-1,5-dione derivatives

Tetrahedron , 2012, 68 (14), 3098-3102

DOI: 10.1016/j.tet.2012.01.096

Iminov R. T.; Tverdokhlebov A. V.; Tolmachev A. A.; Volovenko Y. M.; Shishkina S. V.; Shishkin O. V.

Design and Synthesis of Polycyclic Imidazole-Containing N-Heterocycles based on C-H Activation/Cyclization Reactions

Adv. Synth. Catal. , 2012, 354 (13), 2495-2503

DOI: 10.1002/adsc.201200221

Iaroshenko V. O.; Ostrovskyi D.; Miliutina M.; Maalik A.; Villinger A.; Tolmachev A.; Volochnyuk D. M.; Langer P.

2,3-Unsubstituted chromones and their enaminone precursors as versatile reagents for the synthesis of fused pyridines

Org. Biomol. Chem. , 2012, 10 (4), 890-894

DOI: 10.1039/C1OB06494K

Iaroshenko V. O.; Mkrtchyan S.; Gevorgyan A.; Miliutina M.; Villinger A.; Volochnyuk D.; Sosnovskikh V. Y.; Langer P.

Focused enumeration and assessing the structural diversity of scaffold libraries: conformationally restricted bicyclic secondary diamines

Mol. Diver. , 2012, 16 (3), 477-487

DOI: 10.1007/s11030-012-9381-2

Grygorenko O.; Prytulyak R.; Volochnyuk D.; Kudrya V.; Khavryuchenko O.; Komarov I.

“Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles

J. Org. Chem. 2012, 77 (1), 47-56

DOI: 10.1021/jo202305c

Gerus I. I.; Mironetz R. X.; Kondratov I. S.; Bezdudny A. V.; Dmytriv Y. V.; Shishkin O. V.; Starova V. S.; Zaporozhets O. A.; Tolmachev A. A.; Mykhailiuk P. K.

Easy Synthesis of Novel 4-Azolylpyridazin-3-ones

Synthesis , 2012, 44 (08), 1263-1267

DOI: 10.1055/s-0031-1290808

Geraschenko O. V.; Khodakovskiy P. V.; Shivanyuk O. N.; Shishkin O. V.; Mykhailiuk P. K.; Tolmachev A. A.

On the regioselectivity of the reaction of cyanothioacetamide with 2-acetylcyclo-hexanone, 2-acetylcyclopentanone, and 2-acetyl-1-(morpholin-4-yl)-1-cycloalkenes

Chem. Heterocycl. Compd. , 2012, 48 (2), 309-319

DOI: 10.1007/s10593-012-0991-5

Dotsenko V. V.; Krivokolysko S. G.; Polovinko V. V.; Litvinov V. P.

Additions and Corrections: 3-Benzyl-3-azabicyclo[3.1.1]heptan-6-one: a promising building block for medicinal chemistry

Org. Lett. , 2012, 14 (6), 1660

DOI: 10.1021/ol3004707

Denisenko A. V.; Mityuk A. P.; Grygorenko O. O.; Volochnyuk D. M.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.

An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines

Synthesis , 2012, 44 (17), 2739-2742

DOI: 10.1055/s-0032-1316985

Alekseenko A. N.; Klukovsky D.; Lukin O.; Mykhailiuk P. K.; Shishkin O. V.; Pustovit Y. M.

A Library of Conformationally Restricted Saturated Heterocyclic Sulfonyl Chlorides

Synthesis , 2011, 22, 3669-3674

DOI: 10.1055/s-0030-1260223

Zhersh S.; Buryanov V. V.; Karpenko O. V.; Grygorenko O. O.; Tolmachev A. A.

Synthesis of β-fluoro-β-proline

Tetrahedron Lett. , 2011, 52 (12), 1300-1302

DOI: 10.1016/j.tetlet.2011.01.070

Yarmolchuk V. S.; Mykhailiuk P. K.; Komarov I. V.

An Entry into Hexahydro-2H-thieno[2,3-c]pyrrole 1,1-Dioxide Derivatives

J. Org. Chem. , 2011, 76 (17), 7010-7016

DOI: 10.1021/jo200878t

Yarmolchuk V. S.; Mukan I. L.; Grygorenko O. O.; Tolmachev A. A.; Shishkina S. V.; Shishkin O. V.; Komarov I. V.

Conformational Changes of the Multispecific Transporter Organic Anion Transporter 1 (OAT1/SLC22A6) Suggests a Molecular Mechanism for Initial Stages of Drug and Metabolite Transport

Cell Biochemistry and Biophysics , 2011, 61 (2), 251-259

DOI: 10.1007/s12013-011-9191-7

Tsigelny I.; Kovalskyy D.; Kouznetsova V.; Balinskyi O.; Sharikov Y.; Bhatnagar V.; Nigam S.

Catalytic Hydrogenation of 3-Amino-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-ones and Its Use in the Synthesis of Trifluoromethyl-Containing Mimetics of Ornithine and Thalidomide

Synthesis , 2011, 07, 1149-1156

DOI: 10.1055/s-0030-1258448

Tolmachova N. A.; Dolovanyuk V. G.; Gerus I. I.; Kondratov I. S.; Polovinko V. V.; Bergander K.; Haufe G.

Aminoheterocycles as synthons for combinatorial Biginelli reactions

Mol. Diver. , 2011, 15 (1), 189-195

DOI: 10.1007/s11030-010-9253-6

Ryabukhin S.; Plaskon A.; Boron S.; Volochnyuk D.; Tolmachev A.

Expedient Synthesis of cis- and trans-3-Aminocyclobutanecarboxylic Acids

Synth. Commun. , 2011, 41 (11), 1644-1649

DOI: 10.1080/00397911.2010.491595

Radchenko D. S.; Tkachenko A.; Grygorenko O. O.; Komarov I. V.

Condensed isoquinolines. 37.* Heterocyclization using 3-(arylamino)- and 3-(hetarylamino)isoquinolin-1(2H)-ones

Chem. Heterocycl. Compd. , 2011, 47 (3), 342-354

DOI: 10.1007/s10593-011-0763-7

Potikha L. M.; Gutsul R. M.; Plaskon A. S.; Kovtunenko V. A.; Tolmachev A. A.

3-Methoxalylchromone - A Versatile Reagent for the Regioselective Synthesis of 1-Desazapurine

Synthesis , 2011, 01, 133-141

DOI: 10.1055/s-0030-1258339

Ostrovskyi D.; Iaroshenko V. O.; Ali I.; Mkrtchyan S.; Villinger A.; Tolmachev A.; Langer P.
 

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