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Eur. J. Org. Chem. 2016, 33, 5485-5493

DOI: 10.1002/ejoc.201600947

Mykhailiuk P.; Ishchenko A.; Stepanenko V.; Cossy J.

C2F5-substituted pyrazolines were synthesized by [3+2]-cycloaddition between in situ generated C2F5CHN2 and electron-deficient alkenes. Addition of DBU led to elimination of HF to give CF3CHF-pyrazoles. Depending on the structure of the pyrazolines, however, different products were obtained.

Synthesis of fluoroalkyl pyrazoles from in situ generated C2F5CHN2 and electron-deficient alkenes

 

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