Synthesis 2017, 49 (14), 3112-3117
DOI: 10.1055/s-0036-1588785
Grygorenko O.; Sokolenko Y.; Ostapchuk E.; Artemenko A.
Synthesis 2017, An approach to 3-oxa-7-azabicyclo[3.3.0]octanes, bicyclic morpholine analogues, is reported, which relies on [3+2] cycloaddition of maleic anhydrides or furan-2(5H)-ones and an in situ generated azomethine ylide. The utility of the method was demonstrated on a multigram scale.