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Heterocycl. Commun. , 2018, 24 (4), 237-240

DOI: 10.1515/hc-2018-0013

Vlasov S.; Kovalenko S.; Shynkarenko P.; Krolenko K. Vlasov V.

Syntheses of 3-(4-arylthieno[2,3-d]pyrimidin-2-yl)-2H-chromen-2-ones 5 by the reaction of 2-iminocoumarin-3-carboxamides 1 with (2-aminothiophen-3-yl)(aryl)methanones 2 and by the alternative Suzuki coupling of 4-chlorothieno[2,3-d]pyrimidin-2-yl-2H-chromen-2-one 7 with arylboronic acids were developed. Compound 5d showed higher antimicrobial activity against Staphylococcus aureus than the reference drug streptomycin.

Vlasov S.; Kovalenko S.; Shynkarenko P.; Krolenko K. Vlasov V.
Heterocycl. Commun. 2018, 24 (4), 237-240
DOI: 10.1515/hc-2018-0013

 

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