Publications

Synthesis of 2,2-disubstituted spirocyclic pyrrolidines by intramolecular Dieckmann condensation

Eur. J. Org. Chem. 2019, (22), 3553-3559

DOI: 10.1002/ejoc.201801750

Fominova K.; Diachuk T.; Sadkova I.; Mykhailiuk P.

Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents

Eur. J. Med. Chem. 2019, 174 292-308

DOI: 10.1016/j.ejmech.2019.04.052

Kryshchyshyn A.; Kaminskyy D.; Karpenko O.; Gzella A.; Grellier P.; Lesyk R.

Cationic ring contraction of seven-membered cycle of 3,4-dihydro-2H-1,5-benzoxathiepine derivatives

Chem. Heterocycl. Compd. 2019, 55 (4-5), 416-420

DOI: 10.1007/s10593-019-02474-w

Tarasiuk T.; Shyshkina O.; Potikha L.; Volovenko Y.

N-Boc-4-aminopyrazole-5-carbaldehydes in Friendländer synthesis of pyrazolo[4,3-b]pyridines

Chem. Heterocycl. Compd. 2019, 55 (4-5), 379-385

DOI: 10.1007/s10593-019-02468-8

Yakovenko G.; Lukianov O.; Bol’but A.; Vovk M.

Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks

J. Org. Chem. 2019, 84 (13), 8487-8496

DOI: 10.1021/acs.joc.9b00719

Chernykh A.; Melnykov K.; Tolmacheva N.; Kondratov I.; Radchenko D.; Daniliuc C.; Volochnyuk D.; Ryabukhin S.; Kuchkovska Y.; Grygorenko O.

Pd-Catalyzed directed CH-(hetero)arylation of cyclic α-amino acids: effects of substituents and the ring size

Org. Biomol. Chem. 2019, 17, 4342-4349

DOI: 10.1039/c9ob00393b

Hutskalova V.; Mykhailiuk P.

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines

J. Am. Chem. Soc. 2019, 141 (16), 6726-6739

DOI: 10.1021/jacs.9b02238

Ni S.; Padial N.; Kingston C.; Vantourout J.; Schmitt D.; Edwards J.; Kruszyk M.; Merchant R.; Mykhailiuk P.; Sanchez B.; Yang S.; Perry M.; Gallego G.; Mousseau J.; Collins M.; Cherney R.; Lebed P.; Chen J.; Qin T.; Baran P.

General, Practical and Selective Oxidation Protocol for CF₃S into CF₃S(O) Group

Molecules 2019, 24 (7)

DOI: 10.3390/molecules24071249

Sokolenko L.; Orlova R.; Filatov A.; Yagupolskii Y.; Magnier E.; Pegot B.; Diter P.

Synthesis, Modification, and Anticonvulsant Activity of 3′-R¹ - Spiro[indoline-3,6′-[1,2,4]triazino[2,3-c]quinazolin]-2,2′(7′H)-diones Derivatives

J. Heterocycl. Chem. 2019, 56 (5), 1605-1612

DOI: 10.1002/jhet.3541

Voskoboynik O.; Kolomoets O.; Nosulenko I.; Berest G.; Bilyi A.; Karpenko O.; Belenichev I.; Kovalenko S.

Efficient method for the synthesis of novel substituted thieno[2,3-d]pyrimidine-4-carboxylic acids, their derivatization, and antimicrobial activity

Chem. Heterocycl. Compd. 2019, 55 (2), 184-188

DOI: 10.1007/s10593-019-02437-1

Vlasova O.; Krolenko K.; Nechayev M.; Shynkarenko P.; Kabachnyy V.; Vlasov S.

Synthesis of 1-hetaryl-2,2-difluorocyclopropane-derived building blocks: the case of pyrazoles

J. Fluorine Chem. 2019, 217, 80-89

DOI: 10.1016/j.jfluchem.2018.11.006

Nosik P.; Ryabukhin S.; Pashko M.; Grabchuk G.; Grygorenko O.; Volochnyuk D.

Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives

Org. Lett. 2019, 21 (7), 2340-2345

DOI: 10.1021/acs.orglett.9b00622

Sukach V.; Melnykov S.; Bertho S.; Diachenko I.; Retailleau P.; Vovk M.; Gillaizeau I.

Saturated bioisosteres of benzene: where to go next?

Org. Biomol. Chem. 2019, 17 (11), 2839-2849

DOI: 10.1039/c8ob02812e

Mykhailiuk P.

Pros and cons of virtual screening based on public "Big Data": In silico mining for new bromodomain inhibitors

Eur. J. Med. Chem. 2019, 165, 258-272

DOI: 10.1016/j.ejmech.2019.01.010

Casciuc I.; Horvath D.; Gryniukova A.; Tolmachova K.; Vasylchenko O.; Borysko P.; Moroz Y.; Bajorath J.; Varnek A.

Electrochemical C(sp³)-H Fluorination

Synlett 2019, 30 (10), 1178-1182

DOI: 10.1055/s-0037-1611737

Takahira Y.; Chen M.; Kawamata Y.; Mykhailiuk P.; Nakamura H.; Peters B.; Reisberg S.; Li C.; Chen L.; Hoshikawa T.; Shibuguchi T.; Baran P.

Absorption- and Excitation-Modulated Luminescence of Pr³⁺, Nd³⁺, and Lu³⁺ Compounds with Dianions of Tetrafluoroterephthalic and Camphoric Acids

ACS Omega 2019, 4 (2), 2669−2675

DOI: 10.1021/acsomega.8b02388

Mikhalyova E.; Khomenko O.; Gavrilenko K.; Dotsenko V.; Addison A.; Pavlishchuk V.

Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space

Chemistry 2019, 25 (28), 6928-6940

DOI: 10.1002/chem.201900440

Zasukha S.; Timoshenko V.; Tolmachev A.; Pivnytska V.; Gavrylenko O.; Zhersh S.; Shermolovich Y.; Grygorenko O.

Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents

Angew. Chem. Int. Ed. 2019, 58 (8), 2454-2458

DOI: 10.1002/anie.201814524

Chen T.; Zhang H.; Mykhailiuk P.; Merchant R.; Smith C.; Qin T.; Baran P.

Ultra-large library docking for discovering new chemotypes

Nature 2019, 566 (7743), 224-229

DOI: 10.1038/s41586-019-0917-9

Lyu J.; Wang S.; Balius T.; Singh I.; Levit A.; Moroz Y.; O'Meara M.; Che T.; Algaa E.; Tolmachova K.; Tolmachev A.; Shoichet B.; Roth B.; Irwin J.

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki-Miyaura Reactions of Bromooxazole Building Blocks

Eur. J. Org. Chem. 2019, (18), 2884-2898

DOI: 10.1002/ejoc.201900032

Solomin V.; Radchenko D.; Slobodyanyuk E.; Geraschenko O.; Vashchenko B.; Grygorenko O.

Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group-A Model for yet Unknown Peptidases?

Molecules 2019, 24 (3), 572

DOI: 10.3390/molecules24030572

Komarov I.; Ishchenko A.; Hovtvianitsa A.; Stepanenko V.; Kharchenko S.; Bond A.; Kirby A.

Difluorodiazoethane (CF₂HCHN₂ ): A New Reagent for the Introduction of the Difluoromethyl Group

Chem. Eur. J. 2019, 25 (20)

DOI: 10.1002/chem.201804953

Mykhailiuk P.; Koenigs R.

A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

Amino Acids 2019, 51 (2), 255-261

DOI: 10.1007/s00726-018-2660-1

Melnykov K.; Volochnyuk D.; Ryabukhin S.; Rusanov, E.; Grygorenko O.

3-((Hetera)cyclobutyl)azetidines, “Stretched” Analogues of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery

J. Org. Chem. 2019, 84 (3), 1363-1371

DOI: 10.1021/acs.joc.8b02822

Feskov I.; Chernykh A.; Kuchkovska Y.; Daniliuc C.; Kondratov I.; Grygorenko O.

Structure-Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents

J. Med. Chem. 2018, 61 (23), 10793-10813

DOI: 10.1021/acs.jmedchem.8b01428

Babii O.; Afonin S.; Ishchenko A.; Schober T.; Negelia A.; Tolstanova G.; Garmanchuk L.; Ostapchenko L.; Komarov I.; Ulrich A.

Synthesis of 4-(2H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one via Ring-Switching Hydrazinolysis of 5-Ethoxymethylidenethiazolo [3,2-b][1,2,4]triazol-6-one

MolBank 2018, 4, 1022

DOI: 10.3390/M1022

Holota S.; Shylych Y.; Derkach H.; Karpenko O.; Gzella A.; Lesyk R.

Comparative effects of trifluoromethyl- and methyl-group substitutions in proline

New J. Chem. 2018, 42 (16), 13461-13470

DOI: 10.1039/c8nj02631a

Kubyshkin V.; Pridma S.; Budisa N.

Formation of hierarchically-ordered nanoporous silver foam and its electrocatalytic properties in reductive dehalogenation of organic compounds

New J. Chem. 2018, 42 (21), 17499-17512

DOI: 10.1039/C8NJ03460E

Mishura A.; Lytvynenko A.; Gavrilenko K.; Baranchikov A.; Grabovaya N.; Kiskin M.; Kolotilov S.

Synthesis and antitumor activities of new n-(5-benzylthiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides

Biopolym. Cell. 2018, 34 (1), 59-71

DOI: 10.7124/bc.000971

Ostapiuk Y.; Frolov D.; Vasylyschyn R.; Matiychuk V.

Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes

J. Org. Chem. 2018, 83 (12), 6275-6289

DOI: 10.1021/acs.joc.8b00077

Skalenko Y.; Druzhenko T.; Denisenko A.; Samoilenko M.; Dacenko O.; Trofymchuk S.; Grygorenko O.; Tolmachev A.; Mykhailiuk P.

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking

Org. Biomol. Chem. 2018, 16 (44), 8559-8564

DOI: 10.1039/C8OB02428F

Strizhak A.; Sharma K.; Babii O.; Afonin S.; Ulrich A.; Komarov I.; Spring D.

Synthesis of benzofuro[3,2-b]furo[2,3-d]pyridin-4(5H)-ones, derivatives of a novel heterocyclic system

Heterocycl. Commun. 2018, 24 (4), 177-181

DOI: 10.1515/hc-2017-0143

Yahodkina-Yakovenko M.; Bol'but A.; Vovk M.

Synthesis of azabicyclo[n.1.0]alkane-derived bifunctional building blocks via the Corey–Chaykovsky cyclopropanation

Tetrahedron Lett. 2018, 59 (52), 4611-4615

DOI: 10.1016/j.tetlet.2018.11.047

Yarmoliuk D.; Serhiichuk D.; Smyrnov V.; Tymtsunik A.; Hryshchuk O.; Kuchkovska Y.; Grygorenko O.

One-Pot Synthesis of 6-Aminopyrido[2,3-d]pyrimidin-7-ones

Eur. J. Org. Chem. 2018, 46, 6519-6523

DOI: 10.1002/ejoc.201801204

Zinchenko A.; Muzychka L.; Kucher O.; Sadkova I.; Mykhailiuk P.; Smolii O.

Synthesis of 4-Hetarylisoxazoles from Amino Acid-Derived Halogenoximes and Push-Pull Enamines

Eur. J. Org. Chem. 2018, 40, 5585-5595

DOI: 10.1002/ejoc.201800753

Chalyk B.; Hrebeniuk K.; Gavrilenko K.; Kulik I.; Rozhenko A.; Volochnyuk D.; Liashuk O.; Grygorenko O.

Regioselective synthesis of isoxazole and 1,2,4-oxadiazole-derived phosphonates via [3 + 2] cycloaddition

Org. Biomol. Chem. 2018, 16 (47), 9152-9164

DOI: 10.1039/C8OB02257G

Chalyk B.; Sosedko A.; Volochnyuk D.; Tolmachev A.; Gavrilenko K.; Liashuk O.; Grygorenko O.

Hetaryl Bromides Bearing SO₂F Group - Versatile Substrates for Palladium-Catalyzed C-C Coupling Reactions

Eur. J. Org. Chem. 2018, 47, 6682-6692

DOI: 10.1002/ejoc.201801270

Cherepakha A.; Stepannikova K.; Vashchenko B.; Gorichko M.; Tolmachev A.; Grygorenko O.

Diastereoselective Synthesis of Cyclic sp³-Enriched cis-β-Alkoxysulfonyl Chlorides

Synthesis 2018, 51 (4) 848-858

DOI: 10.1055/s-0037-1611277

Grygorenko O.; Sokolov A.; Golovach S.; Kozlinsky I.; Dolia K.; Tolmachev A.; Kuchkovska Y.

Low Heat of Adsorption of Ethylene Achieved by Major Solid-State Structural Rearrangement of a Discrete Copper(I) Complex

Angew. Chem. 2018, 57 (50), 16442-16446

DOI: 10.1002/anie.201810460

Jayaratna N.; Cowan M.; Parasar D.; Funke H.; Reibenspies J.; Mykhailiuk P.; Artamonov O.; Noble R.; Dias H.

(Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library

ACS Comb. Sci. 2018, 20 (11), 672-680

DOI: 10.1021/acscombsci.8b00130

Tolmachova K.; Moroz Y.; Konovets A.; Platonov M.; Vasylchenko O.; Borysko P.; Zozulya S.; Gryniukova A.; Bogolubsky A.; Pipko S.; Mykhailiuk P.; Brovarets V.; Grygorenko O.