Publications

Saturated Bioisosteres of ortho-Substituted Benzenes

Angew. Chem. Int. Ed. 2020, in press

DOI: 10.1002/anie.202004183

Denisenko A.; Garbuz P.; Shishkina S.; Voloshchuk N.; Mykhailiuk P.

Formyl MIDA Boronate: C₁ Building Block Enables Straightforward Access to α-Functionalized Organoboron Derivatives

Angew. Chem. Int. Ed. 2020, in press

DOI: 10.1002/anie.202007651

Ivon Y.; Mazurenko I.; Kuchkovska Y.; Voitenko Z.; Grygorenko O.

2,2,2-Trifluorodiazoethane (CF₃CHN₂): A Long Journey since 1943

Chem. Rev. 2020, in press

DOI: 10.1021/acs.chemrev.0c00406

Mykhailiuk P.

Synthesis of spirocyclic β‐ and γ‐sultams by one‐pot reductive cyclization of cyanoalkylsulfonyl fluorides

Eur. J. Org. Chem. 2020, in press

DOI: 10.1002/ejoc.202000351

Stepannikova K.; Vashchenko B.; Grygorenko O.; Gorichko M.; Cherepakha A.; Moroz Y.; Volovenko Y.; Zhersh S.

Multigram Synthesis of Advanced 6,6-Difluorospiro[3.3]heptane-derived Building Blocks

Eur. J. Org. Chem. 2020, in press

DOI: 10.1002/ejoc.202000432

Olifir O.; Chernykh A.; Dobrydnev A.; Grygorenko O.; Moroz Y.; Voitenko Z.; Radchenko D.

NMR quality control of fragment libraries for screening

J. Biomol. NMR 2020, in press

DOI: 10.1007/s10858-020-00327-9

Sreeramulu S.; Richter C.; Kuehn T.; Azzaoui K.; Blommers M.; Del Conte R.; Fragai M.; Trieloff N.; Schmieder P.; Nazare M.; Specker E.; Ivanov V.; Oschkinat H.; Banci L.; Schwalbe H.

Fluoral Hydrate: A Perspective Substrate for the Castagnoli-Cushman Reaction

ACS Omega 2020, 5 (33), 20932-20942

DOI: 10.1021/acsomega.0c02394

Adamovskyi M.; Avramenko M.; Volochnyuk D.; Ryabukhin S.

Fluoroalkyl-Substituted Cyclopropane Derivatives: Synthesis and Physicochemical Properties

J. Org. Chem. 2020, 85 (19), 12692-12702

DOI: 10.1021/acs.joc.0c01848

Chernykh A.; Olifir O.; Kuchkovska Y.; Volochnyuk D.; Yarmolchuk V.; Grygorenko O.

Chan-Evans-Lam N1-(het)arylation and N1-alksmall ie, Cyrillicnylation of 4-fluoroalkylpyrimidin-2(1H)-ones

Beilstein J. Org. Chem. 2020, 16, 2304-2313

DOI: 10.3762/bjoc.16.191

Tkachuk V.; Lukianov O.; Vovk M.; Gillaizeau I.; Sukach V.

Reactions of cyclic β-alkoxyvinyl α-keto esters with heteroaromatic NCC-binucleophiles

Chem. Heterocycl. Compd. 2020, 56 (3), 377–385

DOI: 10.1007/s10593-020-02670-z

Stepaniuk O.; Vashchenko B.; Matvienko V.; Kondratov I.; Tolmachev A.; Grygorenko O.

Synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead Nitrogen atom

Eur. J. Org. Chem. 2020, 2020 (22), 3261-3269

DOI: 10.1002/ejoc.202000314

Blahun O.; Melnychenko H.; Kuchkovska Y.; Zhersh S.; Tolmachev A.; Grygorenko O.

Synthesis and oxidation of all isomeric 2-(pyrazolyl)ethanols

Chem. Heterocycl. Compd. 2020, 56 (3), 320-325

DOI: 10.1007/s10593-020-02662-z

Ivonin S.; Rusanov E. B.; Dmitriy V.

A convenient approach to 3-trifluoromethyl-6-azaindoles

J. Fluorine Chem. 2020, 233

DOI: 10.1016/j.jfluchem.2020.109509

Ivonin S.; Yurchenko A.; Voloshchuk V.; Yurchenko S.; Rusanov E.; Pirozhenko V.; Volochnyuk D.; Kostyuk A.

Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4

J. Mol. Struct. 2020, 1210

DOI: 10.1016/j.molstruc.2020.128025

Malashchuk A.; Chernykh A.; Hurmach V.; Platonov M.; Onopchenko O.; Zozulya S.; Daniliuc C.; Dobrydnev A.; Kondratov I.; Moroz Y.; Grygorenko O.

An unexpected synthesis of β-amino-α-mesyl-γ-sultams upon mesylation of hindered α-aminonitriles

Chem. Heterocycl. Compd. 2020, 56 (3), 386–391

DOI: 10.1007/s10593-020-02671-y

Dyachenko M.; Dobrydnev A.; Chuchvera Y.; Shishkina S.; Volovenko Y.

Exploring bulky natural and natural-like periphery in the design of p-(benzyloxy)phenylpropionic acid agonists of free fatty acid receptor 1 (GPR40)

Bioorg. Chem. 2020, 99, 103830

DOI: 10.1016/j.bioorg.2020.103830

Kuranov S.; Luzina O.; Onopchenko O.; Pishel I.; Zozulya S.; Gureev M.; Salakhutdinov N.; Krasavin M.

gem-Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF₃SiMe₃-NaI System

Eur. J. Org. Chem. 2020, (15), 2217-2224

DOI: 10.1002/ejoc.202000346

Hryshchuk O.; Varenyk A.; Yurov Y.; Kuchkovska Y.; Tymtsunik A.; Grygorenko O.

Photochemical [2 + 2] cycloaddition of alkenyl boronic derivatives: an entry into 3-azabicyclo[3.2.0]heptane scaffold

J. Org. Chem. 2020, 85 (9), 5927-5940

DOI: 10.1021/acs.joc.0c00265

Demchuk O.; Hryshchuk O.; Vashchenko B.; Kozytskiy A.; Tymtsunik A.; Komarov I.; Grygorenko O.

Thymus Regeneration and Future Challenges

Stem Cell Rev. 2020, 16 (2), 239-250

DOI: 10.1007/s12015-020-09955-y

Shichkin V.; Antica M.

3‐Carboxy‐/3‐Aminobicyclo[1.1.1]pentane‐Derived Sulfonamides and Sulfonyl Fluorides – Advanced Bifunctional Reagents for Organic Synthesis and Drug Discovery

Eur. J. Org. Chem. 2020, (15), 2210-2216

DOI: 10.1002/ejoc.202000303

Kokhan S.; Valter Y.; Tymtsunik A.; Komarov I.; Grygorenko O.

Synthesis of saturated nitrogen heterocycles by Strecker reaction – nucleophilic cyclization

Tetrahedron Lett. 2020, 61 (12)

DOI: 10.1016/j.tetlet.2020.151645

Grygorenko O.

Synthesis of Fused Pyridine Carboxylates by Reaction of β-Alkoxyvinyl Glyoxylates with Amino Heterocycles

Synthesis 2020, 52 (13), 1915-1926

DOI: 10.1055/s-0039-1707987

Stepaniuk O.; Rudenko T.; Vashchenko B.; Matvienko V.; Kondratov I.; Tolmachev A.; Grygorenko O.

Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction

Org. Biomol. Chem. 2020, 18 (28), 5359-5369

DOI: 10.1039/d0ob00831a

Strizhak A.; Babii O.; Afonin S.; Bakanovich I.; Pantelejevs T.; Xu W.; Fowler E.; Eapen R.; Sharma K.; Platonov M.; Hurmach V.; Itzhaki L.; Hyvonen M.; Ulrich A.; Spring D.; Komarov I.

Twisting and Turning the Sulfonamide Bond: A Synthetic, Quantum Chemical, and Crystallographic Study

J. Org. Chem. 2020, 85 (8), 5288-5299

DOI: 10.1021/acs.joc.9b03394

Blahun O.; Rozhenko A.; Rusanov E.; Zhersh S.; Tolmachev A.; Volochnyuk D.; Grygorenko O.

Strategy for the synthesis of 2,2-disubstituted 8-azachromanones via Horner–Wadsworth–Emmons olefination

Chem. Heterocycl. Compd. 2020, 56 (2), 213–218

DOI: 10.1007/s10593-020-02646-z

Omelian T.; Ostapchuk E.; Dobrydnev A.; Malets Y.; Brovarets V.; Grygorenko O.

An open-source drug discovery platform enables ultra-large virtual screens

Nature 2020, 580 (7805), 663-668

DOI: 10.1038/s41586-020-2117-z

Gorgulla C.; Boeszoermenyi A.; Wang Z.; Fischer P.; Coote P.; Padmanabha Das K.; Malets Y.; Radchenko D.; Moroz Y.; Scott D.; Fackeldey K.; Hoffmann M.; Iavniuk I.; Wagner G.; Arthanari H.

(Het)aryl Difluoromethyl‐Substituted β‐Alkoxyenones: Synthesis and Heterocyclizations

Eur. J. Org. Chem. 2020, 2020 (9), 1069-1077

DOI: 10.1002/ejoc.201901833

Bugera M.; Tarasenko K.; Kondratov I.; Gerus I.; Vashchenko B.; Ivasyshyn V.; Grygorenko O.

Heterocyclizations of α-heteroatom-substituted organoboronates (microreview)

Chem. Heterocycl. Compd. 2020, 56 (2), 170-172

DOI: 10.1007/s10593-020-02641-4

Grygorenko O.; Ivon Y.

Synthesis, physico-chemical properties and microsomal stability of compounds bearing aliphatic trifluoromethoxy group

J. Fluorine Chem. 2020, 231, 109461

DOI: 10.1016/j.jfluchem.2020.109461

Logvinenko I.; Markushyna Y.; Kondratov I.; Vashchenko B.; Kliachyna M.; Tokaryeva Y.; Pivnytska V.; Grygorenko O.; Haufe G.

Water-soluble non-classical benzene mimics

Angew. Chem. 2020, 59 (18), 7161-7167

DOI: 10.1002/anie.202000548

Levterov V.; Panasyuk Y.; Pivnytska V.; Mykhailiuk P.

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

Nature 2020, 579 (7800), 609-614

DOI: 10.1038/s41586-020-2027-0

Stein R.; Kang H.; McCorvy J.; Glatfelter G.; Jones A.; Che T.; Slocum S.; Huang X.; Savych O.; Moroz Y.; Stauch B.; Johansson L.; Cherezov V.; Kenakin T.; Irwin J.; Shoichet B.; Roth B.; Dubocovich M.

Aliphatic α‐Boryl‐α‐bromoketones: Synthesis and Reactivity

Eur. J. Org. Chem. 2020, 2020 (23), 3367-3377

DOI: 10.1002/ejoc.202000078

Ivon Y.; Kuchkovska Y.; Voitenko Z.; Grygorenko O.

Semi-Industrial Fluorination of β-Keto Esters with SF₄: Safety vs Efficacy

Synlett 2020, 31 (06), 565-574

DOI: 10.1055/s-0037-1610744

Trofymchuk S.; Kliukovskyi D.; Semenov S.; Khairulin A.; Shevchenko V.; Bugera M.; Tarasenko K.; Volochnyuk D.; Ryabukhin S.

Deoxofluorination of (Hetero)aromatic Acids

J. Org. Chem. 2020, 85 (5), 3110-3124

DOI: 10.1021/acs.joc.9b03011

Trofymchuk S.; Bugera M.; Klipkov A.; Razhyk B.; Semenov S.; Tarasenko K.; Starova V.; Zaporozhets O.; Tananaiko O.; Alekseenko A.; Pustovit Y.; Kiriakov O.; Gerus I.; Tolmachev A.; Mykhailiuk P.

The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

Chem. Eur. J. 2020, 26 (6), 1196-1237

DOI: 10.1002/chem.201903232

Grygorenko O.; Volochnyuk D.; Ryabukhin S.; Judd D.

Synthesis and chemical transformations of diazolyl α,α-difluoroacetates

J. Fluorine Chem. 2020, 229

DOI: 10.1016/j.jfluchem.2019.109407

Geraschenko O.; Solomin V.; Vashchenko B.; Khodakivskyi P.; Tolmachev A.; Grygorenko O.

Diazoacetonitrile (N₂CHCN): A Long Forgotten but Valuable Reagent for Organic Synthesis

Chem. Eur. J. 2020, 26 (1), 89-101

DOI: 10.1002/chem.201903335

Mykhailiuk P.; Koenigs R.

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

J. Enzyme Inhib. Med. Chem. 2020, 35 (1), 306‑310

DOI: 10.1080/14756366.2019.1698562

Krasavin M.; Kalinin S.; Zozulya S.; Gryniukova A.; Borysko P.; Angeli A.; Supuran C.

Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

J. Enzyme Inhib. Med. Chem. 2020, 35 (1), 165‑171

DOI: 10.1080/14756366.2019.1693556

Krasavin M.; Kalinin S.; Zozulya S.; Griniukova A.; Borysko P.; Angeli A.; Supuran C.

Synthesis of naphtho[1,2-b]-, naphtho[2,1-b]-, and naphtho[2,3-b]azepinones via proton-induced cyclization of N-1(2)-naphthyl styrylacetamides

J. Heterocycl. Chem. 2020, 57 (1), 317-326

DOI: 10.1002/jhet.3779

Danyliuk I.; Vaskevych R.; Vaskevych A.; Suikov S.; Rusanov E.; Chornous V.; Vovk M.

Building the Housane: Diastereoselective Synthesis and Characterization of Bicyclo[2.1.0]pentane Carboxylic Acids

J. Org. Chem. 2020, 85 (4), 2321-2337

DOI: 10.1021/acs.joc.9b03044

Semeno V.; Vasylchenko V.; Vashchenko B.; Lutsenko D.; Iminov R.; Volovenko O.; Grygorenko O.

A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Sci. Rep. 2019, 9 (1), 19585

DOI: 10.1038/s41598-019-55069-y

Chiba S.; Ohue M.; Gryniukova A.; Borysko P.; Zozulya S.; Yasuo N.; Yoshino R.; et al.

Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes

J. Org. Chem. 2019, 84 (24), 15877-15899

DOI: 10.1021/acs.joc.9b02264

Chalyk B.; Hrebeniuk K.; Fil Y.; Gavrilenko K.; Rozhenko A.; Vashchenko B.; Borysov O.; Biitseva A.; Lebed P.; Bakanovych I.; Moroz Y.; Grygorenko O.

Supreme activity of gramicidin S against resistant, persistent and biofilm cells of staphylococci and enterococci

Sci. Rep. 2019, 9 (1), 17938

DOI: 10.1038/s41598-019-54212-z

Berditsch M.; Afonin S.; Reuster J.; Lux H.; Schkolin K.; Babii O.; Radchenko D. S.; Abdullah I.; William N.; Middel V.; Strahle U.; Nelson A.; Valko K.; Ulrich A.