Publications

Reaction of N,N-Disubstituted Polyfluoroalkanethioamides with Diazomethane: Entry to New Thiirane Derivatives

Eur. J. Org. Chem. 2020, 2021 (47), 6524-6529

DOI: 10.1002/ejoc.202001104

Shermolovich Y.; Khyzhan A.; Rusanov E.; Mazepa A.; Rakipov I.; Mykhaylychenko S.

Bicyclic Pyrrolidines for Medicinal Chemistry via [3 + 2]-Cycloaddition

J. Org. Chem. 2021, 86 (19), 13289–13309

DOI: 10.1002/slct.202001243

Savych V.; Mykhalchuk V.; Melnychuk P.; Isakov A.; Savchuk T.; Timoshenko V.; Siry S.; Pavlenko S.; Kovalenko D.; Hryshchuk O.; Reznik V.; Chalyk B.; Yarmolchuk V.; Rusanov E.

Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF₄)

J. Org. Chem. 2021, 86 (17), 12181–12198

DOI: 10.1021/acs.joc.1c01518

Trofymchuk S.; Bugera M.; Klipkov A.; Ahunovych V.; Razhyk B.; Semenov S.; Boretskyi A.; Tarasenko K.; Mykhailiuk P.

Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists

J. Enzyme Inhib. Med. Chem. 2021, 36 (1), 1651-1658

DOI: 10.1080/14756366.2021.1955874

Lukin A.; Bakholdina A.; Chudinov M.; Onopchenko O.; Zhuravel E.; Zozulya S.; Gureev M.; Krasavin M.

Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation

Life 2021, 11(7), 659

DOI: 10.3390/life11070659

Rayevsky A.; Sirokha D.; Samofalova D.; Lozhko D.; Gorodna O.; Prokopenko I.; Livshits L.

Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP)

J. Org. Chem. 2021, 86 (20), 14061–14068

DOI: 10.1021/acs.joc.1c00977

Ripenko V.; Vysochyn D.; Klymov I.; Zhersh S.; Mykhailiuk P.

Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL

Chem Sci 2021, 12(28), 9694‑9703

DOI: 10.1039/d1sc01916c

Wong J. Y.; Mukherjee R.; Miao J.; Bilyk O.; Triana V.; Miskolzie M.; Henninot A.; Dwyer J.; Kharchenko S.; Iampolska A.; Volochnyuk D.; Lin Y.; Postovit L.; Derda R.

Third Generation Buchwald Precatalysts with XPhos and RuPhos: Multigram Scale Synthesis, Solvent-Dependent Isomerization of XPhos Pd G3 and Quality Control by ¹H- and ³¹P-NMR Spectroscopy

Molecules 2021, 26(12), 3507

DOI: 10.3390/molecules26123507

Sotnik S.; Mishchenko A.; Rusanov E.; Kozytskiy A.; Gavrilenko K.; Ryabukhin S.; Volochnyuk D.; Kolotilov S.

Selective α-Methylation of Ketones

J. Org. Chem. 2021, 86 (11), 7333-7346

DOI: 10.1021/acs.joc.1c00148

Frolov A.; Ostapchuk E.; Pashenko A.; Chuchvera Y.; Rusanov E.; Volochnyuk D.; Ryabukhin S.

Modelling of an autonomous Nav1.5 channel system as a part of in silico pharmacology study

J. Mol. Model. 2021, 27 (6), 182

DOI: 10.1007/s00894-021-04799-w

Rayevsky A.; Samofalova D.; Maximyuk O.; Platonov M.; Hurmach V.; Ryabukhin S.; Volochnyuk D.

Cu-Catalyzed Pyridine Synthesis via Oxidative Annulation of Cyclic Ketones with Propargylamine

J. Org. Chem. 2021, 86 (11), 7315-7325

DOI: 10.1021/acs.joc.0c03038

Sotnik S.; Subota A.; Kliuchynskyi A.; Yehorov D.; Lytvynenko A.; Rozhenko A.; Kolotilov S.; Ryabukhin S.; Volochnyuk D.

Nature of Fast Relaxation Processes and Spectroscopy of a Membrane-Active Peptide Modified with Fluorescent Amino Acid Exhibiting Excited State Intramolecular Proton Transfer and Efficient Stimulated Emission

ACS Omega 2021, 6 (15), 10119–10128

DOI: 10.1021/acsomega.1c00193

Shaydyuk Y.; Bashmakova N.; Dmytruk A.; Kachkovsky O.; Koniev S.; Strizhak A.; Komarov I.; Belfield K.; Bondar M.; Babii O.

One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles

Mol. Divers. 2021

DOI: 10.1007/s11030-021-10218-2

Radchenko D.; Naumchyk V.; Dziuba I.; Kyrylchuk A.; Gubina K.; Moroz Y.; Grygorenko O.

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

iScience 2021, 24 (2), 102021

DOI: 10.1016/j.isci.2020.102021

Gorgulla C.; Padmanabha Das K.; Leigh K.; Cespugli M.; Fischer P.; Wang Z.; Tesseyre G.; Pandita S.; Shnapir A.; Calderaio A.; Gechev M.; Rose A.; Lewis N.; et al.

Versatile Reactivity of Mn(II) Complexes in Reactions with N-Donor Heterocycles: Metamorphosis of Labile Homometallic Pivalates vs. Assembling of Endurable Heterometallic Acetates

Molecules 2021, 26 (4), 1021

DOI: 10.3390/molecules26041021

Polunin R.; Evstifeev I.; Cador O.; Golhen S.; Gavrilenko K.; Lytvynenko A.; Efimov N.; Minin V.; Bogomyakov A.; Ouahab L.; Kolotilov S.; Kiskin M.; Eremenko I.

Effect of Charge Distribution in a Modified tRNA Substrate on Pre-Reaction Protein-tRNA Complex Geometry

ACS Omega 2021, 6 (6), 4227-4235

DOI: 10.1021/acsomega.0c05143

Rayevsky A.; Sharifi M.; Demianenko E.; Volochnyuk D.; Tukalo M.

Synthesis of Furoneoflavones Modified by Coumarin and (HET)Aroyl Substituents

Chem. Nat. Compd. 2021, 57 (1), 33-37

DOI: 10.1007/s10600-021-03275-4

Shokol T.; Moskvina V.; Hlibov Y.; Frasinyuk M.; Khilya V.

Fluoroalkyl-Containing 1,2-Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry

Eur. J. Org. Chem. 2021, 2021 (1), 87-95

DOI: 10.1002/ejoc.202001345

Demchuk O.; Hryshchuk O.; Vashchenko B.; Trofymchuk S.; Melnykov K.; Skreminskiy A.; Volochnyuk D.; Grygorenko O.

Citraconic acid and its anhydride-based hetero-Diels–Alder reactions in the synthesis of new thiopyrano[2,3-d][1,3]thiazole derivatives

Synth. Commun. 2021, 51 (6), 964-970

DOI: 10.1080/00397911.2020.1867868

Zelisko N.; Karpenko O.; Muzychenko V.; Gzella A.; Lesyk R.

Synthesis of 4-heteryl-substituted derivatives of methylpyrazolo[1,5-a]pyrazine-4-carboxylates

Chem. Heterocycl. Compd. 2020, 56 (12), 1554-1559

DOI: 10.1007/s10593-020-02849-4

Tsizorik N.; Hrynyshyn Y.; Musiychuk A.; Bol’but A.; Nechayev M.; Vovk M.

Fluorinated Pyrazoles: From Synthesis to Applications

Chem. Rev. 2021, 121 (3), 1670–1715

DOI: 10.1021/acs.chemrev.0c01015

Mykhailiuk P.

Chemography: Searching for Hidden Treasures

J. Chem. Inf. Model. 2021, 61 (1), 179-188

DOI: 10.1021/acs.jcim.0c00936

Zabolotna Y.; Lin A.; Horvath D.; Marcou G.; Volochnyuk D.; Varnek A.

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

J. Extracell. Vesicles 2020, 10 (2), e12039

DOI: 10.1002/jev2.12039

Leblanc R.; Kashyap R.; Barral K.; Egea-Jimenez A. L.; Kovalskyy D.; Feracci M.; Garcia M.; Derviaux C.; Betzi S.; Ghossoub R.; Platonov M.; Roche P.; Morelli X.; Hoffer L.; Zimmermann P.

Synthesis of α-spirocyclic pyrrolidines

Chem. Heterocycl. Compd. 2020, 56 (11), 1411-1413

DOI: 10.1007/s10593-020-02829-8

Melnykov K.; Ryabukhin S.

Exploration of the nitrogen heterocyclic periphery around the core of the advanced FFA1 agonist fasiglifam (TAK-875)

Arch. Pharm. 2021, 354 (4), e2000275

DOI: 10.1002/ardp.202000275

Lukin A.; Bakholdina A.; Zhurilo N.; Onopchenko O.; Zhuravel E.; Zozulya S.; Gureev M.; Safrygin A.; Krasavin M.

[3-(Dimethylamino)-2-(trifluoromethyl)prop-2-en-1-ylidene]dimethylazanium hexafluorophosphate – efficient reagent for the formation of trifluoromethyl-substituted azaheterocycles

Chem. Heterocycl. Compd. 2020, 56 (11), 1408-1410

DOI: 10.1007/s10593-020-02828-9

Mityuk A.; Ryabukhin S.

Modern Approaches to the Creation of Immobilized Metal-Complex Catalysts for Hydrogenation, Alkene Metathesis, and Cross-Coupling Processes: A Review

Theor. Exp. Chem. 2020, 56 (5), 283-308

DOI: 10.1007/s11237-020-09660-4

Ivanytsya M.; Ryabukhin S.; Volochnyuk D.; Kolotilov S.

Bicyclic Piperidines via [2 + 2] Photocycloaddition

J. Org. Chem. 2021, 86 (3), 2200-2209

DOI: 10.1021/acs.joc.0c02355

Shcherbakova V.; Dibchak D.; Snisarenko M.; Skalenko Y.; Denisenko A.; Kuznetsova A.; Mykhailiuk P.

Enantiomeric N-tert-Butylsulfinyl Imines of Methyl Trifluoropyruvate: Promising Building Blocks in Asymmetric Synthesis of α-Trifluoromethylated Amino Acids and Derivatives

ChemistrySelect 2020, 5 (43), 13569-13574

DOI: 10.1002/slct.202003500

Cherednichenko A.; Bezgubenko L.; Rusanov E.; Onys'ko P.; Rassukana Y.

Efficient synthesis of imidazole and pyrimidine derivatives

Chem. Heterocycl. Compd. 2020, 56 (10), 1329-1334

DOI: 10.1007/s10593-020-02818-x

Kolomoitsev O.; Gladkov E.; Kotlyar V.; Pedan P.; Onipko O.; Buravov O.; Chebanov V.

SAVI, in silico generation of billions of easily synthesizable compounds through expert-system type rules

Scientific Data 2020, 7 (1), 384

DOI: 10.1038/s41597-020-00727-4

Patel H.; Ihlenfeldt W.; Judson P.; Moroz Y.; Pevzner Y.; Peach M.; Delannee V.; Tarasova N.; Nicklaus M.

Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy

Cells 2020, 9 (10), 2272

DOI: 10.3390/cells9102272

Adams V.; Gussen V.; Zozulya S.; Cruz A.; Moriscot A.; Linke A.; Labeit S.

Composites Based on Nanodispersed Nickel, Graphene-Like Carbon, and Aerosil for Catalytic Hydrogenation of Furfural and Quinoline

Theor. Exp. Chem. 2020, 56 (4), 261-267

DOI: 110.1007/s11237-020-09657-z

Asaula V.; Shvets O.; Pariiska O.; Bur’yanov V.; Ryabukhin S.; Volochnyuk D.; Kolotilov S.

An efficient method for accessing carboannulated and functionalized [1,2,3]triazolo[4,5-b]pyridines

Chem. Heterocycl. Compd. 2020, 56 (8), 1048‑1053

DOI: 10.1007/s10593-020-02771-9

Syrota N.; Kemskiy S.; Bol’but A.; Chernobaev I.; Vovk M.

Chan-Evans-Lam N1-(het)arylation and N1-alksmall ie, Cyrillicnylation of 4-fluoroalkylpyrimidin-2(1H)-ones

Beilstein J. Org. Chem. 2020, 16, 2304-2313

DOI: 10.3762/bjoc.16.191

Tkachuk V.; Lukianov O.; Vovk M.; Gillaizeau I.; Sukach V.

2,2,2-Trifluorodiazoethane (CF₃CHN₂): A Long Journey since 1943

Chem. Rev. 2020, 120 (22), 12718-12755

DOI: 10.1021/acs.chemrev.0c00406

Mykhailiuk P.

Practical synthetic method for functionalized 1-methyl-3/5-(trifluoromethyl)-1H-pyrazoles

Org. Process Res. Dev. 2020, 24 (11), 2619‑2632

DOI: 10.1021/acs.oprd.0c00300

Tairov M.; Levchenko V.; Stadniy I.; Dmytriv Y.; Dehtiarov S.; Kibalnyi M.; Melnyk A.; Veselovych S.; Borodulin Y.; Kolotilov S.; Ryabukhin S.; Volochnyuk D.

Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction

Org. Biomol. Chem. 2020, 18 (28), 5359-5369

DOI: 10.1039/d0ob00831a

Strizhak A.; Babii O.; Afonin S.; Bakanovich I.; Pantelejevs T.; Xu W.; Fowler E.; Eapen R.; Sharma K.; Platonov M.; Hurmach V.; Itzhaki L.; Hyvonen M.; Ulrich A.; Spring D.; Komarov I.

Photoregulated macrocyclic cell-penetrating peptides

Chem. Heterocycl. Compd. 2020, 56 (6), 719-721

DOI: 10.1007/s10593-020-02721-5

Komarov I.; Bakanovych I.

Saturated Bioisosteres of ortho-Substituted Benzenes

Angew. Chem. Int. Ed. 2020, 59 (46), 20515‑20521

DOI: 10.1002/anie.202004183

Denisenko A.; Garbuz P.; Shishkina S.; Voloshchuk N.; Mykhailiuk P.

Peptidyl inhibition of Spt4-Spt5: Protein-protein inhibitors for targeting the transcriptional pathway related to C9orf72 expansion repeats

J. Cell. Biochem. 2020, 121 (12), 4922-4930

DOI: 10.1002/jcb.29820

Rayevsky A.; Platonov M.; Hurmach V.; Yakovenko A.; Volochnyuk D.

Formyl MIDA Boronate: C₁ Building Block Enables Straightforward Access to α-Functionalized Organoboron Derivatives

Angew. Chem. Int. Ed. 2020, 59 (41), 18016‑18022

DOI: 10.1002/anie.202007651

Ivon Y.; Mazurenko I.; Kuchkovska Y.; Voitenko Z.; Grygorenko O.

Synthesis of new-type 1,3,6-triazocine via intramolecular reactions of iodocyclization and [3+2] azido cycloaddition

J. Heterocycl. Chem. 2020, 57(8), 3202‑3212

DOI: 10.1002/jhet.4028

Vaskevych R.; Vaskevych A.; Rusanov E.; Mel'nyk O.; Vovk M.

Z. Anorg. Allg. Chem. 2020, 646 (20), 1710‑1714

DOI: 10.1002/zaac.201900319

Sedykh A.; Sotnik S.; Kurth D.; Volochnyuk D.; Kolotilov S.; Müller-Buschbaum K.

NMR quality control of fragment libraries for screening

J. Biomol. NMR 2020, 74 (10-11), 555–563

DOI: 10.1007/s10858-020-00327-9

Sreeramulu S.; Richter C.; Kuehn T.; Azzaoui K.; Blommers M.; Del Conte R.; Fragai M.; Trieloff N.; Schmieder P.; Nazare M.; Specker E.; Ivanov V.; Oschkinat H.; Banci L.; Schwalbe H.

Electrochemical Scaled-up Synthesis of Cyclic Enecarbamates as Starting Materials for Medicinal Chemistry Relevant Building Bocks

Advanced Synthesis and Catalysis 2020, 362 (15), 3229-3242

DOI: 10.1002/adsc.202000450

Tereshchenko O.; Perebiynis M.; Knysh I.; Vasylets O.; Sorochenko A.; Slobodyanyuk E.; Rusanov E.; Borysov O.; Kolotilov S.; Ryabukhin S.; Volochnyuk D.