Publications

Aliphatic α‐Boryl‐α‐bromoketones: Synthesis and Reactivity

Eur. J. Org. Chem. 2020, in press

DOI: 10.1002/ejoc.202000078

Ivon Y.; Kuchkovska Y.; Voitenko Z.; Grygorenko O.

Synthesis of spirocyclic β‐ and γ‐sultams by one‐pot reductive cyclization of cyanoalkylsulfonyl fluorides

Eur. J. Org. Chem. 2020, in press

DOI: 10.1002/ejoc.202000351

Stepannikova K.; Vashchenko B.; Grygorenko O.; Gorichko M.; Cherepakha A.; Moroz Y.; Volovenko Y.; Zhersh S.

Synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead Nitrogen atom

Eur. J. Org. Chem. 2020, in press

DOI: 10.1002/ejoc.202000314

Blahun O.; Melnychenko H.; Kuchkovska Y.; Zhersh S.; Tolmachev A.; Grygorenko O.

Multigram Synthesis of Advanced 6,6-Difluorospiro[3.3]heptane-derived Building Blocks

Eur. J. Org. Chem. 2020, in press

DOI: 10.1002/ejoc.202000432

Olifir O.; Chernykh A.; Dobrydnev A.; Grygorenko O.; Moroz Y.; Voitenko Z.; Radchenko D.

Reactions of cyclic β-alkoxyvinyl α-keto esters with heteroaromatic NCC-binucleophiles

Chem. Heterocycl. Compd. 2020, 56 (3), 377–385

DOI: 10.1007/s10593-020-02670-z

Stepaniuk O.; Vashchenko B.; Matvienko V.; Kondratov I.; Tolmachev A.; Grygorenko O.

Synthesis and oxidation of all isomeric 2-(pyrazolyl)ethanols

Chem. Heterocycl. Compd. 2020, 56, 320-325

DOI: 10.1007/s10593-020-02662-z

Ivonin S.; Rusanov E. B.; Dmitriy V.

A convenient approach to 3-trifluoromethyl-6-azaindoles

J. Fluorine Chem. 2020, 233

DOI: 10.1016/j.jfluchem.2020.109509

Ivonin S.; Yurchenko A.; Voloshchuk V.; Yurchenko S.; Rusanov E.; Pirozhenko V.; Volochnyuk D.; Kostyuk A.

Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4

J. Mol. Struct. 2020, 1210

DOI: 10.1016/j.molstruc.2020.128025

Malashchuk A.; Chernykh A.; Hurmach V.; Platonov M.; Onopchenko O.; Zozulya S.; Daniliuc C.; Dobrydnev A.; Kondratov I.; Moroz Y.; Grygorenko O.

An unexpected synthesis of β-amino-α-mesyl-γ-sultams upon mesylation of hindered α-aminonitriles

Chem. Heterocycl. Compd. 2020, 56, 386–391

DOI: 10.1007/s10593-020-02671-y

Dyachenko M.; Dobrydnev A.; Chuchvera Y.; Shishkina S.; Volovenko Y.

gem-Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF₃SiMe₃-NaI System

Eur. J. Org. Chem. 2020, (15), 2217-2224

DOI: 10.1002/ejoc.202000346

Hryshchuk O.; Varenyk A.; Yurov Y.; Kuchkovska Y.; Tymtsunik A.; Grygorenko O.

Photochemical [2 + 2] cycloaddition of alkenyl boronic derivatives: an entry into 3-azabicyclo[3.2.0]heptane scaffold

J. Org. Chem. 2020, 85 (9), 5927-5940

DOI: 10.1021/acs.joc.0c00265

Demchuk O.; Hryshchuk O.; Vashchenko B.; Kozytskiy A.; Tymtsunik A.; Komarov I.; Grygorenko O.

3‐Carboxy‐/3‐Aminobicyclo[1.1.1]pentane‐Derived Sulfonamides and Sulfonyl Fluorides – Advanced Bifunctional Reagents for Organic Synthesis and Drug Discovery

Eur. J. Org. Chem. 2020, (15), 2210-2216

DOI: 10.1002/ejoc.202000303

Kokhan S.; Valter Y.; Tymtsunik A.; Komarov I.; Grygorenko O.

Synthesis of saturated nitrogen heterocycles by Strecker reaction – nucleophilic cyclization

Tetrahedron Lett. 2020, 61 (12)

DOI: 10.1016/j.tetlet.2020.151645

Grygorenko O.

Twisting and Turning the Sulfonamide Bond: A Synthetic, Quantum Chemical, and Crystallographic Study

J. Org. Chem. 2020, 85 (8), 5288-5299

DOI: 10.1021/acs.joc.9b03394

Blahun O.; Rozhenko A.; Rusanov E.; Zhersh S.; Tolmachev A.; Volochnyuk D.; Grygorenko O.

Strategy for the synthesis of 2,2-disubstituted 8-azachromanones via Horner–Wadsworth–Emmons olefination

Chem. Heterocycl. Compd. 2020, 56, 213–218

DOI: 10.1007/s10593-020-02646-z

Omelian T.; Ostapchuk E.; Dobrydnev A.; Malets Y.; Brovarets V.; Grygorenko O.

An open-source drug discovery platform enables ultra-large virtual screens

Nature 2020, 580 (7805), 663-668

DOI: 10.1038/s41586-020-2117-z

Gorgulla C.; Boeszoermenyi A.; Wang Z.; Fischer P.; Coote P.; Padmanabha Das K.; Malets Y.; Radchenko D.; Moroz Y.; Scott D.; Fackeldey K.; Hoffmann M.; Iavniuk I.; Wagner G.; Arthanari H.

(Het)aryl Difluoromethyl‐Substituted β‐Alkoxyenones: Synthesis and Heterocyclizations

Eur. J. Org. Chem. 2020, 2020 (9), 1069-1077

DOI: 10.1002/ejoc.201901833

Bugera M.; Tarasenko K.; Kondratov I.; Gerus I.; Vashchenko B.; Ivasyshyn V.; Grygorenko O.

Heterocyclizations of α-heteroatom-substituted organoboronates (microreview)

Chem. Heterocycl. Compd. 2020, 56 (2), 170-172

DOI: 10.1007/s10593-020-02641-4

Grygorenko O.; Ivon Y.

Synthesis, physico-chemical properties and microsomal stability of compounds bearing aliphatic trifluoromethoxy group

J. Fluorine Chem. 2020, 231, 109461

DOI: 10.1016/j.jfluchem.2020.109461

Logvinenko I.; Markushyna Y.; Kondratov I.; Vashchenko B.; Kliachyna M.; Tokaryeva Y.; Pivnytska V.; Grygorenko O.; Haufe G.

Water-soluble non-classical benzene mimics

Angew. Chem. 2020, 59 (18), 7161-7167

DOI: 10.1002/anie.202000548

Levterov V.; Panasyuk Y.; Pivnytska V.; Mykhailiuk P.

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

Nature 2020, 579 (7800), 609-614

DOI: 10.1038/s41586-020-2027-0

Stein R.; Kang H.; McCorvy J.; Glatfelter G.; Jones A.; Che T.; Slocum S.; Huang X.; Savych O.; Moroz Y.; Stauch B.; Johansson L.; Cherezov V.; Kenakin T.; Irwin J.; Shoichet B.; Roth B.; Dubocovich M.

Semi-Industrial Fluorination of β-Keto Esters with SF₄: Safety vs Efficacy

Synlett 2020, 31 (06), 565-574

DOI: 10.1055/s-0037-1610744

Trofymchuk S.; Kliukovskyi D.; Semenov S.; Khairulin A.; Shevchenko V.; Bugera M.; Tarasenko K.; Volochnyuk D.; Ryabukhin S.

Deoxofluorination of (Hetero)aromatic Acids

J. Org. Chem. 2020, 85 (5), 3110-3124

DOI: 10.1021/acs.joc.9b03011

Trofymchuk S.; Bugera M.; Klipkov A.; Razhyk B.; Semenov S.; Tarasenko K.; Starova V.; Zaporozhets O.; Tananaiko O.; Alekseenko A.; Pustovit Y.; Kiriakov O.; Gerus I.; Tolmachev A.; Mykhailiuk P.

The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

Chem. Eur. J. 2020, 26 (6), 1196-1237

DOI: 10.1002/chem.201903232

Grygorenko O.; Volochnyuk D.; Ryabukhin S.; Judd D.

Synthesis and chemical transformations of diazolyl α,α-difluoroacetates

J. Fluorine Chem. 2020, 229

DOI: 10.1016/j.jfluchem.2019.109407

Geraschenko O.; Solomin V.; Vashchenko B.; Khodakivskyi P.; Tolmachev A.; Grygorenko O.

Diazoacetonitrile (N₂CHCN): A Long Forgotten but Valuable Reagent for Organic Synthesis

Chem. Eur. J. 2020, 26 (1), 89-101

DOI: 10.1002/chem.201903335

Mykhailiuk P.; Koenigs R.

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

J. Enzyme Inhib. Med. Chem. 2020, 35 (1), 306‑310

DOI: 10.1080/14756366.2019.1698562

Krasavin M.; Kalinin S.; Zozulya S.; Gryniukova A.; Borysko P.; Angeli A.; Supuran C.

Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

J. Enzyme Inhib. Med. Chem. 2020, 35 (1), 165‑171

DOI: 10.1080/14756366.2019.1693556

Krasavin M.; Kalinin S.; Zozulya S.; Griniukova A.; Borysko P.; Angeli A.; Supuran C.

Synthesis of naphtho[1,2-b]-, naphtho[2,1-b]-, and naphtho[2,3-b]azepinones via proton-induced cyclization of N-1(2)-naphthyl styrylacetamides

J. Heterocycl. Chem. 2020, 57 (1), 317-326

DOI: 10.1002/jhet.3779

Danyliuk I.; Vaskevych R.; Vaskevych A.; Suikov S.; Rusanov E.; Chornous V.; Vovk M.

Building the Housane: Diastereoselective Synthesis and Characterization of Bicyclo[2.1.0]pentane Carboxylic Acids

J. Org. Chem. 2020, 85 (4), 2321-2337

DOI: 10.1021/acs.joc.9b03044

Semeno V.; Vasylchenko V.; Vashchenko B.; Lutsenko D.; Iminov R.; Volovenko O.; Grygorenko O.

A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Sci. Rep. 2019, 9 (1), 19585

DOI: 10.1038/s41598-019-55069-y

Chiba S.; Ohue M.; Gryniukova A.; Borysko P.; Zozulya S.; Yasuo N.; Yoshino R.; et al.

Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes

J. Org. Chem. 2019, 84 (24), 15877-15899

DOI: 10.1021/acs.joc.9b02264

Chalyk B.; Hrebeniuk K.; Fil Y.; Gavrilenko K.; Rozhenko A.; Vashchenko B.; Borysov O.; Biitseva A.; Lebed P.; Bakanovych I.; Moroz Y.; Grygorenko O.

Supreme activity of gramicidin S against resistant, persistent and biofilm cells of staphylococci and enterococci

Sci. Rep. 2019, 9 (1), 17938

DOI: 10.1038/s41598-019-54212-z

Berditsch M.; Afonin S.; Reuster J.; Lux H.; Schkolin K.; Babii O.; Radchenko D. S.; Abdullah I.; William N.; Middel V.; Strahle U.; Nelson A.; Valko K.; Ulrich A.

Synthesis of azachromones and azachromanones

Chem. Heterocycl. Compd. 2019, 55 (11), 1007–1012

DOI: 10.1007/s10593-019-02570-x

Malets Y.; Moskvina V.; Grygorenko O.; Brovarets V.

Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki–Miyaura cross coupling

Chem. Heterocycl. Compd. 2019, 55 (11), 1070-1074

DOI: 10.1007/s10593-019-02579-2

Hrynyshyn Y.; Musiychuk A.; Tsizorik N.; Bol’but A.; Vovk M.

4-(Boc-amino)-1Н-1,2,3-triazole-5-carboxylic acids –convenient reagents for the synthesis of 1,4,6,7-tetrahydro[1,2,3]- triazolo[4,5-е][1,4]diazepine-5,8-diones

Chem. Heterocycl. Compd. 2019, 55 (11), 1092‑1097

DOI: 10.1007/s10593-019-02583-6

Syrota N.; Kemskiy S.; Bol’but A.; Vovk M.

Synthesis of fluorinated dipyrazolyl sulfones from bis(2-fluoro-2-polyfluoroalkylalkenyl) sulfones and diazomethane

Chem. Heterocycl. Compd. 2019, 55 (11), 1065-1069

DOI: 10.1007/s10593-019-02578-3

Borodkin Y.; Rusanov E.; Khizhan A.; Shermolovich Y.

Far Away from Flatland. Synthesis and Molecular Structure of Dihetera[3.3.n]propellanes and Trihetera[3.3.n]propellanes: Advanced Analogues of Morpholine/Piperazine

J. Org. Chem. 2019, 84 (21), 13908-13921

DOI: 10.1021/acs.joc.9b02067

Sokolenko Y.; Yurov Y.; Vashchenko B.; Hryshchuk O.; Filimonova Y.; Ostapchuk E.; Artemenko A.; Zaremba O.; Grygorenko O.

Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles

J. Org. Chem. 2019, 84 (23), 15212-15225

DOI: 10.1021/acs.joc.9b02258

Chalyk B.; Khutorianskyi A.; Lysenko A.; Fil Y.; Kuchkovska Y.; Gavrilenko K.; Bakanovych I.; Moroz Y.; Gorlova A.; Grygorenko O.

Synthesis of pyrazolo[1,5-a]pyrazin-4-ylacetonitriles and their annulation with pyridine ring

Chem. Heterocycl. Compd. 2019, 55 (9), 893‑896

DOI: 10.1007/s10593-019-02554-x

Tsizorik N.; Hrynyshyn Y.; Musiychuk A.; Bol’but A.; Vovk M.

Hetaryl-substituted bicyclo[1.1.1]pentanes

Chem. Heterocycl. Compd. 2019, 55 (10), 933‑935

DOI: 10.1007/s10593-019-02558-7

Grygorenko O.; Kokhan S.

Multigram Synthesis and C−C/C−N Couplings of Functionalized 1,2‐Disubstituted Cyclopropyltrifluoroborates

Adv. Synth. Catal. 2019, 361 (23), 5428-5439

DOI: 10.1002/adsc.201900879

Hryshchuk O.; Yurov Y.; Tymtsunik A.; Kovtunenko V.; Komarov I.; Grygorenko O.

Convenient Access to Conformationally Rigid Sultams

Org. Lett. 2019, 21 (22), 8909-8914

DOI: 10.1021/acs.orglett.9b03080

Dibchak D.; Shcherbacova V.; Denisenko A.; Mykhailiuk P.

Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization

J. Org. Chem. 2019, 84 (23), 15106-15117

DOI: 10.1021/acs.joc.9b01947

Bychek R.; Hutskalova V.; Bas J.; Zaporozhets O.; Zozulia S.; Levterov V.; Mykhailiuk P.

Cascade reactions for constructing heterocycles containing a pyrimidino-pyrazino-pyrimidine core using 1,2,4-triazole scaffolds

Tetrahedron Lett. 2019, 60 (39), 151089 - 4

DOI: 10.1016/j.tetlet.2019.151089

Khomenko D.; Doroshchuk R.; Raspertova I.; García López J.; López Ortiz F.; Shova S.; Iegorov O.; Lampeka R.

Hindered dialkyl ether synthesis with electrogenerated carbocations

Nature 2019, 573 (7774), 398-402

DOI: 10.1038/s41586-019-1539-y

Xiang J.; Shang M.; Kawamata Y.; Lundberg H.; Reisberg S.; Chen M.; Mykhailiuk P.; Beutner G.; Collins M.; Davies A.; Del Bel M.; Gallego G.; Spangler J.; Starr J.; Yang S.; Blackmond D.; Baran P.

SAR by space: Enriching hit sets from the chemical space

Molecules 2019, 24 (17), 3096

DOI: 10.3390/molecules24173096

Klingler F.; Gastreich M.; Grygorenko O.; Savych O.; Borysko P.; Griniukova A.; Gubina K.; Lemmen C.; Moroz Y.