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Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives

Org. Lett. 2019, 21 (7), 2340-2345

DOI: 10.1021/acs.orglett.9b00622

Sukach V.; Melnykov S.; Bertho S.; Diachenko I.; Retailleau P.; Vovk M.; Gillaizeau I.
Saturated bioisosteres of benzene: where to go next?

Org. Biomol. Chem. 2019, 17 (11), 2839-2849

DOI: 10.1039/c8ob02812e

Mykhailiuk P.
Pros and cons of virtual screening based on public "Big Data": In silico mining for new bromodomain inhibitors

Eur. J. Med. Chem. 2019, 165, 258-272

DOI: 10.1016/j.ejmech.2019.01.010

Casciuc I.; Horvath D.; Gryniukova A.; Tolmachova K.; Vasylchenko O.; Borysko P.; Moroz Y.; Bajorath J.; Varnek A.
Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents

Angew. Chem. Int. Ed. 2019, 58 (8), 2454-2458

DOI: 10.1002/anie.201814524

Chen T.; Zhang H.; Mykhailiuk P.; Merchant R.; Smith C.; Qin T.; Baran P.
Ultra-large library docking for discovering new chemotypes

Nature 2019, 566 (7743), 224-229

DOI: 10.1038/s41586-019-0917-9

Lyu J.; Wang S.; Balius T.; Singh I.; Levit A.; Moroz Y.; O'Meara M.; Che T.; Algaa E.; Tolmachova K.; Tolmachev A.; Shoichet B.; Roth B.; Irwin J.
Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group-A Model for yet Unknown Peptidases?

Molecules 2019, 24 (3), 572

DOI: 10.3390/molecules24030572

Komarov I.; Ishchenko A.; Hovtvianitsa A.; Stepanenko V.; Kharchenko S.; Bond A.; Kirby A.
Difluorodiazoethane (CF2HCHN2 ): A New Reagent for the Introduction of the Difluoromethyl Group

Chem. Eur. J. 2019, 25 (20)

DOI: 10.1002/chem.201804953

Mykhailiuk P.; Koenigs R.
A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

Amino Acids 2019, 51 (2), 255-261

DOI: 10.1007/s00726-018-2660-1

Melnykov K.; Volochnyuk D.; Ryabukhin S.; Rusanov, E.; Grygorenko O.
3-((Hetera)cyclobutyl)azetidines, “Stretched” Analogues of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery

J. Org. Chem. 2019, 84 (3), 1363-1371

DOI: 10.1021/acs.joc.8b02822

Feskov I.; Chernykh A.; Kuchkovska Y.; Daniliuc C.; Kondratov I.; Grygorenko O.
Structure-Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents

J. Med. Chem. 2018, 61 (23), 10793-10813

DOI: 10.1021/acs.jmedchem.8b01428

Babii O.; Afonin S.; Ishchenko A.; Schober T.; Negelia A.; Tolstanova G.; Garmanchuk L.; Ostapchenko L.; Komarov I.; Ulrich A.
Synthesis of 4-(2H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one via Ring-Switching Hydrazinolysis of 5-Ethoxymethylidenethiazolo [3,2-b][1,2,4]triazol-6-one

MolBank 2018, 4, 1022

DOI: 10.3390/M1022

Holota S.; Shylych Y.; Derkach H.; Karpenko O.; Gzella A.; Lesyk R.
Comparative effects of trifluoromethyl- and methyl-group substitutions in proline

New J. Chem. 2018, 42 (16), 13461-13470

DOI: 10.1039/c8nj02631a

Kubyshkin V.; Pridma S.; Budisa N.
Formation of hierarchically-ordered nanoporous silver foam and its electrocatalytic properties in reductive dehalogenation of organic compounds

New J. Chem. 2018, 42 (21), 17499-17512

DOI: 10.1039/C8NJ03460E

Mishura A.; Lytvynenko A.; Gavrilenko K.; Baranchikov A.; Grabovaya N.; Kiskin M.; Kolotilov S.
Synthesis and antitumor activities of new n-(5-benzylthiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides

Biopolym. Cell. 2018, 34 (1), 59-71

DOI: 10.7124/bc.000971

Ostapiuk Y.; Frolov D.; Vasylyschyn R.; Matiychuk V.
Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes

J. Org. Chem. 2018, 83 (12), 6275-6289

DOI: 10.1021/acs.joc.8b00077

Skalenko Y.; Druzhenko T.; Denisenko A.; Samoilenko M.; Dacenko O.; Trofymchuk S.; Grygorenko O.; Tolmachev A.; Mykhailiuk P.
Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking

Org. Biomol. Chem. 2018, 16 (44), 8559-8564

DOI: 10.1039/C8OB02428F

Strizhak A.; Sharma K.; Babii O.; Afonin S.; Ulrich A.; Komarov I.; Spring D.
Synthesis of benzofuro[3,2-b]furo[2,3-d]pyridin-4(5H)-ones, derivatives of a novel heterocyclic system

Heterocycl. Commun. 2018, 24 (4), 177-181

DOI: 10.1515/hc-2017-0143

Yahodkina-Yakovenko M.; Bol'but A.; Vovk M.
Synthesis of azabicyclo[n.1.0]alkane-derived bifunctional building blocks via the Corey–Chaykovsky cyclopropanation

Tetrahedron Lett. 2018, 59 (52), 4611-4615

DOI: 10.1016/j.tetlet.2018.11.047

Yarmoliuk D.; Serhiichuk D.; Smyrnov V.; Tymtsunik A.; Hryshchuk O.; Kuchkovska Y.; Grygorenko O.
One-Pot Synthesis of 6-Aminopyrido[2,3-d]pyrimidin-7-ones

Eur. J. Org. Chem. 2018, 46, 6519-6523

DOI: 10.1002/ejoc.201801204

Zinchenko A.; Muzychka L.; Kucher O.; Sadkova I.; Mykhailiuk P.; Smolii O.
Synthesis of 4-Hetarylisoxazoles from Amino Acid-Derived Halogenoximes and Push-Pull Enamines

Eur. J. Org. Chem. 2018, 40, 5585-5595

DOI: 10.1002/ejoc.201800753

Chalyk B.; Hrebeniuk K.; Gavrilenko K.; Kulik I.; Rozhenko A.; Volochnyuk D.; Liashuk O.; Grygorenko O.
Regioselective synthesis of isoxazole and 1,2,4-oxadiazole-derived phosphonates via [3 + 2] cycloaddition

Org. Biomol. Chem. 2018, 16 (47), 9152-9164

DOI: 10.1039/C8OB02257G

Chalyk B.; Sosedko A.; Volochnyuk D.; Tolmachev A.; Gavrilenko K.; Liashuk O.; Grygorenko O.
Hetaryl Bromides Bearing SO2F Group - Versatile Substrates for Palladium-Catalyzed C-C Coupling Reactions

Eur. J. Org. Chem. 2018, 47, 6682-6692

DOI: 10.1002/ejoc.201801270

Cherepakha A.; Stepannikova K.; Vashchenko B.; Gorichko M.; Tolmachev A.; Grygorenko O.
Diastereoselective Synthesis of Cyclic sp3-Enriched cis-β-Alkoxysulfonyl Chlorides

Synthesis 2018, 51 (4) 848-858

DOI: 10.1055/s-0037-1611277

Grygorenko O.; Sokolov A.; Golovach S.; Kozlinsky I.; Dolia K.; Tolmachev A.; Kuchkovska Y.
Low Heat of Adsorption of Ethylene Achieved by Major Solid-State Structural Rearrangement of a Discrete Copper(I) Complex

Angew. Chem. 2018, 57 (50), 16442-16446

DOI: 10.1002/anie.201810460

Jayaratna N.; Cowan M.; Parasar D.; Funke H.; Reibenspies J.; Mykhailiuk P.; Artamonov O.; Noble R.; Dias H.
(Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library

ACS Comb. Sci. 2018, 20 (11), 672-680

DOI: 10.1021/acscombsci.8b00130

Tolmachova K.; Moroz Y.; Konovets A.; Platonov M.; Vasylchenko O.; Borysko P.; Zozulya S.; Gryniukova A.; Bogolubsky A.; Pipko S.; Mykhailiuk P.; Brovarets V.; Grygorenko O.
Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity

J. Org. Chem. 2018, 83 (23), 14350–14361

DOI: 10.1021/acs.joc.8b02071

Levterov V.; Michurin O.; Borysko P.; Zozulya S.; Sadkova I.; Tolmachev A.; Mykhailiuk P.
Facile One-Pot Parallel Synthesis of 3-Amino-1,2,4-triazoles

ACS Comb. Sci. 2018, 20 (7), 461-466

DOI: 10.1021/acscombsci.8b00060

Bogolyubsky A.; Savych O.; Zhemera A.; Pipko S.; Grishchenko A.; Konovets A.; Doroshchuk R.; Khomenko D.; Brovarets V.; Moroz Y.; Vybornyi M.
Synthesis of 5-hydroxy- and 5-sulfanyl-substituted [1,2,3]triazolo[4,5-е][1,4]diazepines

Chem. Heterocycl. Compd. 2018, 54 (8), 789-795

DOI: 10.1007/s10593-018-2350-7

Kemskiy S.; Syrota N.; Bol’but A.; Dorokhov V.; Vovk M.
Multigram Synthesis of C4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks

Synthesis 2018, 50 (24), 4949-4957

DOI: 10.1055/s-0037-1610237

Ryabukhin S.; Melnykov K.; Granat D.; Volochnyuk D.; Grygorenko O.
Grignard Reagents and Their N-analogues in the Synthesis of Tricyclic and Tetracyclic Cage-like Lactams

J. Heterocycl. Chem. 2018, 55 (10), 2381-2391

DOI: 10.1002/jhet.3302

Tkachenko I.; Tarabara I.; Omelchenko I.; Palchykov V.
Synthesis, annulation, and heterofunctionalization of 4-hydrazinylpyrazolo[1,5-а]pyrazines

Chem. Heterocycl. Compd. 2018, 54 (7), 710-716

DOI: 10.1007/s10593-018-2337-4

Tsizorik N.; Hrynyshyn Y.; Musiychuk A.; Bol’but A.; Panasenko N.; Vovk M.
Synthesis of 3-Azabicyclo[3.2.0]heptane-Derived Building Blocks via [3+2] Cycloaddition

Eur. J. Org. Chem. 2018, 40, 5596-5604

DOI: 10.1002/ejoc.201800972

Homon A.; Hryshchuk O.; Trofymchuk S.; Michurin O.; Kuchkovska Y.; Radchenko D.; Grygorenko O.
Synthesis of Functionalized 1,4-Dioxanes with an Additional (Hetero)Aliphatic Ring

Synthesis 2018, 50 (18), 3696-3707

DOI: 10.1055/s-0037-1610195

Grygorenko O.; Bondarenko A.; Tolmachev A.; Vashchenko B.
Synthesis of new fluorinated proline analogues from polyfluoroalkyl beta-ketoacetals and ethyl isocyanoacetate

Chem. Commun. 2018, 54 (69), 9683-9686

DOI: 10.1039/c8cc05912h

Tolmachova N.; Kondratov I.; Dolovanyuk V.; Pridma S.; Chernykh A.; Daniliuc C.; Haufe G.
Transition Metal-free gem-difluorocyclopropanation of Alkenes with CF3SiMe3−NaI System: a Recipe for Electron-deficient Substrates

Adv. Synth. Catal. 2018, 360 (21), 4104-4114

DOI: 10.1002/adsc.201801006

Nosik P.; Ryabukhin S.; Grygorenko O.; Volochnyuk D.
Synthesis and antimicrobial evaluation of 3-(4-arylthieno[2,3-d]pyrimidin-2-yl)- 2H-chromen-2-ones

Heterocycl. Commun. , 2018, 24 (4), 237-240

DOI: 10.1515/hc-2018-0013

Vlasov S.; Kovalenko S.; Shynkarenko P.; Krolenko K. Vlasov V.
The application of anthraquinone-based triazenes as equivalents of diazonium salts in reaction with methylene active compounds

Phosphorus, Sulfur Silicon Relat. Elem. 2018, 193 (7), 409-414

DOI: 10.1080/10426507.2018.1452236

Lozynskyi A.; Sabadakh O.; Luchkevich E.; Taras T.; Vynnytska, Renata, Karpenko O.; Novikov V.; Lesyk R.
Straightforward synthesis of fluorinated amino acids by Michael addition of ethyl bromodifluoroacetate to α,β-unsaturated α-amino acid derivatives

J. Fluorine Chem. 2018, 211, 100-108

DOI: 10.1016/j.jfluchem.2018.03.014

Kondratov I.; Bugera M.; Tolmachova N.; Daniliuc C. Haufe G.
Synthesis, Tautomerism, and Antiradical Activity of Novel Pteridinetrione Derivatives

J. Heterocycl. Chem. 2018, 55 (4), 1033-1041

DOI: 10.1002/jhet.3135

Kazunin M.; Voskoboynik O.; Nosulenko I.; Berest G.; Sergeieva T.; Okovytyy S.; Karpenko O.; Priimenko B.; Kovalenko S.
Conformationally Constrained Mono-Fluorinated Arginine as a Cationic Label for Solid-State 19F NMR Analysis of Membrane-Bound Peptide

Eur. J. Org. Chem. 2018, 27-28, 3826-3833

DOI: 10.1002/ejoc.201800473

Michurin O.; Tolmachova K.; Afonin S.; Babii O.; Grage S.; Ulrich A.; Komarov I.; Radchenko D.
Synthesis of Bi- and Polyfunctional Isoxazoles from Amino Acid Derived Halogenoximes and Active Methylene Nitriles

Eur. J. Org. Chem. 2018, 22, 2753-2761

DOI: 10.1002/ejoc.201800311

Chalyk B.; Hrebeniuk K.; Gavrilenko K.; Shablykin O.; Yanshyna O.; Bash D.; Mykhailiuk P.; Liashuk O.; Grygorenko O.
Following Ramachandran 2: exit vector plot (EVP) analysis of disubstituted saturated rings

New J. Chem. 2018, 42 (11), 8355-8365

DOI: 10.1039/C7NJ05015A

Grygorenko O.; Demenko D.; Volochnyuk D.; Komarov I.
Amino sulfonic acids, peptidosulfonamides and other related compounds

Tetrahedron 2018, 74 (13), 1355-1421

DOI: 10.1016/j.tet.2018.01.033

Grygorenko O.; Biitseva A.; Zhersh S.
Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery

Chem. Eur. J. 2018, 24 (21), 5444-5449

DOI: 10.1002/chem.201800193

Kirichok A.; Shton I.; Pishel I.; Zozulya S.; Borysko P.; Kubyshkin V.; Zaporozhets O.; Tolmachev A.; Mykhailiuk P.
[3+2] Cycloaddition of an Azomethyne Ylide and Vinyl Sulfonyl Fluorides ― an Approach to Pyrrolidine-3-sulfonyl Fluorides

Eur. J. Org. Chem. 2018, (22), 2870-2876

DOI: 10.1002/ejoc.201800521

Mykhalchuk V.; Yarmolchuk V.; Doroschuk R.; Tolmachev A.; Grygorenko O.
Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives

Tetrahedron Lett. 2018, 59 (5), 442-444

DOI: 10.1016/j.tetlet.2017.12.065

Yaremchuk I.; Muzychka L.; Smolii O.; Kucher O.; Shishkina S.
Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

RSC Adv. 2018, 8 (10), 5114-5118

DOI: 10.1039/C7RA13141K

Zheng Y.; Yu X.; Lv S.; Mykhailiuk P.; Ma Q.; Hai L.; Wu Y.
Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides

Chem. Eur. J. 2018, 24 (33), 8343-8349

DOI: 10.1002/chem.201801140

Zhersh S.; Blahun O.; Sadkova I.; Tolmachev A.; Moroz Y.; Mykhailiuk P.
Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks

Synthesis 2018, 50 (10), 1973-1978

DOI: 10.1055/s-0037-1609434

Grygorenko O.; Kurkunov M.; Levandovskiy I.; Tymtsunik A.
Synthesis of 8Н-pyrazolo[5',1':3,4]pyrazino[2,1-b]quinazolin-8-ones

Chem. Heterocycl. Compd. 2018, 53 (11), 1242-1247

DOI: 10.1016/j.tetlet.2016.01.094

Hrynyshyn Y.; Tsizorik N.; Musiychuk A.; Bol’but A.; Vovk M.

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