Nat. Commun. 2025, 16 (1), 1132.
DOI: 10.1038/s41467-024-55027-x
Poplavskyi Y.; Ripenko V.; Bova S.; Biitseva A.; Dmitriv Y. et al.
A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.