What’s Going On With Fluorine In 2022?

No doubt Fluorine is an extremely important element for Medicinal chemistry. There are tons of reviews with numerous examples of cases when the introduction of Fluorine or fluorinated groups led to the improvement of activity, selectivity, ADME-properties of the molecules therefore every year we commonly see many fluorinated molecules among FDA-approved drugs.

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"Silver" for Deucravacitinib

Deucravacitinib(FDA-approved on September 9, 2022)


A week ago, FDA-approved TYK2 inhibitor deucravacitinib (trade name Sotyktu) for moderate-to-severe plaque psoriasis and there are several reasons which make the news remarkable.

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Kukhar Street

Last week there was news that is remarkable for the Ukrainian chemical community. Kyiv administration agreed on the renaming of Murmanska street. Now this street will be named after Academician Valery Kukhar.


Such a renaming is a part of the huge campaign in Kyiv and other Ukrainian cities aiming to remove the names of Russian-related names of streets, squares and other objects and give them actual names.

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Humacyte: Innovative Vessels For Ukraine


There are not so much info in the media about this story however I suppose it is remarkable. And while it is not completely my topic, I suppose it is worth sharing, because it obviously demonstrates how innovative products of biotech can help Ukraine today.

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From Single Covalent Binder To New Biotech


Structures of first DUBTACs

Structures of first DUBTACs (from Nature Chemical Biology volume 18, pages 412–421, 2022)


Few weeks ago a new biotech appeared on the map: Vicinitas Therapeutics launched with $65 Million in Series A. The company is focused on developing small-molecule drugs that stop the degradation of specific proteins to restore their levels for therapeutic benefit. The main value and basis of the biotech is the research of Daniel Nomura’s lab at UC Berkeley on so-called Deubiquitinase-targeting chimeras (or DUBTACs) for targeted protein stabilization.

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Professor Sidney Altman

Sidney Altman

Because of the war I’ve missed the news about the death of Sidney Altman on April 5, 2022. Altman is outstanding researcher, who first discovered the catalytical properties of RNA. He shared the Nobel prize in Chemisry with Thomas Cech in 1989. Their research results seem even more important nowadays when RNA-targeted drugs becomes reality.

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Ivan Kondratov
Dear Ann, Thank you very much for the link with photos and this comment, something you'll never find in internet. Indeed it was ... Read More
Friday, 10 June 2022 10:05
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Enamine Charity Fund Report

Dear Friends,


On February 24, Russian army attacked Ukraine at the full scale of its military potential, and started the bloodiest war in the European continent since WWII. As it is unfolding, more and more shocking crimes are committed by Russian forces against Ukrainian civilians. What happened in the cities of Irpen and Bucha shocked not only Ukrainians, but the whole civilized world.


The launch of Enamine Charity Fund was the practical answer by our team to the increasing crisis in Ukraine, and we are thankful to everyone who contributed money to help us provide help to our fellow Ukrainians, including our colleagues and friends in Irpen and Bucha.

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My experience of Russian full-scale invasion


I decided to write this post because I needed to share my feelings for the last 56 days. Of course, I did not experience as much as those who were in the hot areas or took the arms to defend Ukraine, but possibly my personal story might still be interesting to the readers (sorry for the long read with a little bit too much personal touch).

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