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New Building Blocks For Drug Discovery Are Getting Closer: Gem-difluorocyclopropane-derived Amines

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(This article originally appeared at Sciencetrends.com)

 

Modern drug discovery relies heavily on the ability of chemists to produce good starting points for producing high-quality lead compounds. Several concepts were established in the last two decades to aim synthetic organic chemistry onto the proper areas of chemical space, in particular, the so-called lead-oriented approach which describes paradigm shift towards low-molecular-weight, relatively hydrophilic, conformationally restricted, sp3-enriched structures.

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