Publications

A new method for the construction of [1,2,4]triazolo[1,5-a]pyridine system

Chem. Heterocycl. Compd. 2019, 55 (4-5), 367-373

DOI: 10.1007/s10593-019-02466-w

Kovtunenko V.; Potikha L.; Shelepyuk A.; Tarasiuk T.
Cationic ring contraction of seven-membered cycle of 3,4-dihydro-2H-1,5-benzoxathiepine derivatives

Chem. Heterocycl. Compd. 2019, 55 (4-5), 416-420

DOI: 10.1007/s10593-019-02474-w

Tarasiuk T.; Shyshkina O.; Potikha L.; Volovenko Y.
Expanding the chemical space of sp3-enriched 4,5-disubstituted oxazoles via synthesis of novel building blocks

Chem. Heterocycl. Compd. 2019, 55 (4-5), 421-434

DOI: 10.1007/s10593-019-02475-9

Slobodyanyuk E.; Andriienko A.; Vashchenko B.; Volochnyuk D.; Ryabukhin S.; Grygorenko O.
N-Boc-4-aminopyrazole-5-carbaldehydes in Friendländer synthesis of pyrazolo[4,3-b]pyridines

Chem. Heterocycl. Compd. 2019, 55 (4-5), 379-385

DOI: 10.1007/s10593-019-02468-8

Yakovenko G.; Lukianov O.; Bol’but A.; Vovk M.
An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups

J. Fluorine Chem. 2019, 224, 61-66

DOI: 10.1016/j.jfluchem.2019.05.006

Subota A.; Ryabukhin S.; Gorlova A.; Grygorenko O.; Volochnyuk D.
Multigram Synthesis of Functionalized Spirocyclic Diazirines

Eur. J. Org. Chem. 2019, (23), 3744-3750

DOI: 10.1002/ejoc.201900485

Martyloga O.; Myronenko A.; Tkachenko A.; Matvienko V.; Kuchkovska Y.; Grygorenko O.
Scalable and Straightforward Synthesis of All Isomeric (Cyclo)alkylpiperidines

Eur. J. Org. Chem. 2019 (22), 3636-3648

DOI: 10.1002/ejoc.201900450

Subota A.; Lutsenko A.; Vashchenko B.; Volochnyuk D.; Levchenko V.; Dmytriv Y.; Rusanov E.; Gorlova A.; Ryabukhin S.; Grygorenko O.
Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds

Beilstein J. Org. Chem. 2019, 15, 1032-1045

DOI: 10.3762/bjoc.15.101

Lipson V.; Pavlovska T.; Svetlichnaya N.; Poryvai A.; Gorobets N.; Van Der Eycken E.; Konovalova I.; Shiskina S.; Borisov A.; Musatov V.; Mazepa A.
Synthesis of Novel 3 a-Substituted Tetrahydro-1H-1λ6 -pyrrolo[1,2-b]isothiazole-1,1,3(2H)-triones through the CSIC Reaction

ChemistrySelect 2019, 4 (17), 4933-4937

DOI: 10.1002/slct.201900650

Omelian T.; Dobrydnev A.; Ostapchuk E.; Volovenko Y. M.
Pd-Catalyzed directed CH-(hetero)arylation of cyclic α-amino acids: effects of substituents and the ring size

Org. Biomol. Chem. 2019, 17, 4342-4349

DOI: 10.1039/c9ob00393b

Hutskalova V.; Mykhailiuk P.
Scalable Synthesis of Biologically Relevant Spirocyclic Pyrrolidines

ACS Omega 2019, 4 (4), 7498-7515

DOI: 10.1021/acsomega.9b00896

Melnykov K.; Artemenko A.; Ivanenko B.; Sokolenko Y.; Nosik P.; Ostapchuk E.; Grygorenko O.; Volochnyuk D.; Ryabukhin S.
Recent advances in (hetero)cyclizations of N-vinylazoles

Chem. Heterocycl. Compd. 2019, 55 (3), 196‑198

DOI: 10.1007/s10593-019-02440-6

Grygorenko O.; Nosik P.
Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks

J. Org. Chem. 2019, 84 (13), 8487-8496

DOI: 10.1021/acs.joc.9b00719

Chernykh A.; Melnykov K.; Tolmacheva N.; Kondratov I.; Radchenko D.; Daniliuc C.; Volochnyuk D.; Ryabukhin S.; Kuchkovska Y.; Grygorenko O.
A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines

J. Am. Chem. Soc. 2019, 141 (16), 6726-6739

DOI: 10.1021/jacs.9b02238

Ni S.; Padial N.; Kingston C.; Vantourout J.; Schmitt D.; Edwards J.; Kruszyk M.; Merchant R.; Mykhailiuk P.; Sanchez B.; Yang S.; Perry M.; Gallego G.; Mousseau J.; Collins M.; Cherney R.; Lebed P.; Chen J.; Qin T.; Baran P.
N-Difluorocyclopropyl-Substituted Pyrazoles: Synthesis and Reactivity

Eur. J. Org. Chem. 2019, (27), 4311-4319

DOI: 10.1002/ejoc.201900123

Nosik P.; Poturai A.; Pashko M.; Melnykov K.; Ryabukhin S.; Volochnyuk D.; Grygorenko O.
General, Practical and Selective Oxidation Protocol for CF3S into CF3S(O) Group

Molecules 2019, 24 (7), 1249-1260

DOI: 10.3390/molecules24071249

Sokolenko L.; Orlova R.; Filatov A.; Yagupolskii Y.; Magnier E.; Pegot B.; Diter P.
Synthesis, Modification, and Anticonvulsant Activity of 3′-R1 - Spiro[indoline-3,6′-[1,2,4]triazino[2,3-c]quinazolin]-2,2′(7′H)-diones Derivatives

J. Heterocycl. Chem. 2019, 56 (5), 1605-1612

DOI: 10.1002/jhet.3541

Voskoboynik O.; Kolomoets O.; Nosulenko I.; Berest G.; Bilyi A.; Karpenko O.; Belenichev I.; Kovalenko S.
Efficient method for the synthesis of novel substituted thieno[2,3-d]pyrimidine-4-carboxylic acids, their derivatization, and antimicrobial activity

Chem. Heterocycl. Compd. 2019, 55 (2), 184‑188

DOI: 10.1007/s10593-019-02437-1

Vlasova O.; Krolenko K.; Nechayev M.; Shynkarenko P.; Kabachnyy V.; Vlasov S.
Synthesis of 4-polyfluoroalkyl-1,3-dithiolanes via [3+2] cycloaddition of thiocarbonyl ylide to polyfluoroalkanethioamides

Chem. Heterocycl. Compd. 2019, 55 (2), 189‑192

DOI: 10.1007/s10593-019-02438-0

Mykhaylychenko S.; Markitanov Y.; Rudenko T.; Rusanov E.; Shermolovich Y.
Synthesis of 1-hetaryl-2,2-difluorocyclopropane-derived building blocks: the case of pyrazoles

J. Fluorine Chem. 2019, 217, 80-89

DOI: 10.1016/j.jfluchem.2018.11.006

Nosik P.; Ryabukhin S.; Pashko M.; Grabchuk G.; Grygorenko O.; Volochnyuk D.
Decoration of 1,3-oxazole by alkyl substituents via CH activation

Chem. Heterocycl. Compd. 2019, 55 (3), 202‑204

DOI: 10.1007/s10593-019-02442-4

Slobodyanyuk E.; Volochnyuk D.
Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform

Regen. Med. 2019, 14 (3), 243-255

DOI: 10.2217/rme-2019-0001

Stacey G.; Andrews P.; Barbaric I.; Boiers C.; Chandra A.; Cossu G.; Csontos L.; Frith T.; Halliwell J.; Hewitt Z.; McCall M.; Moore H.; Parmar M.; Panico M.; Pisupati V.; Shichkin V.; Stacey A.; Tedesco F.; Thompson O.; Wagey R.
Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives

Org. Lett. 2019, 21 (7), 2340-2345

DOI: 10.1021/acs.orglett.9b00622

Sukach V.; Melnykov S.; Bertho S.; Diachenko I.; Retailleau P.; Vovk M.; Gillaizeau I.
Saturated bioisosteres of benzene: where to go next?

Org. Biomol. Chem. 2019, 17 (11), 2839-2849

DOI: 10.1039/c8ob02812e

Mykhailiuk P.
Pros and cons of virtual screening based on public "Big Data": In silico mining for new bromodomain inhibitors

Eur. J. Med. Chem. 2019, 165, 258-272

DOI: 10.1016/j.ejmech.2019.01.010

Casciuc I.; Horvath D.; Gryniukova A.; Tolmachova K.; Vasylchenko O.; Borysko P.; Moroz Y.; Bajorath J.; Varnek A.
Electrochemical C(sp3)-H Fluorination

Synlett 2019, 30 (10), 1178-1182

DOI: 10.1055/s-0037-1611737

Takahira Y.; Chen M.; Kawamata Y.; Mykhailiuk P.; Nakamura H.; Peters B.; Reisberg S.; Li C.; Chen L.; Hoshikawa T.; Shibuguchi T.; Baran P.
Absorption- and Excitation-Modulated Luminescence of Pr3+, Nd3+, and Lu3+ Compounds with Dianions of Tetrafluoroterephthalic and Camphoric Acids

ACS Omega 2019, 4 (2), 2669−2675

DOI: 10.1021/acsomega.8b02388

Mikhalyova E.; Khomenko O.; Gavrilenko K.; Dotsenko V.; Addison A.; Pavlishchuk V.
Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space

Chemistry 2019, 25 (28), 6928-6940

DOI: 10.1002/chem.201900440

Zasukha S.; Timoshenko V.; Tolmachev A.; Pivnytska V.; Gavrylenko O.; Zhersh S.; Shermolovich Y.; Grygorenko O.
Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents

Angew. Chem. Int. Ed. 2019, 58 (8), 2454-2458

DOI: 10.1002/anie.201814524

Chen T.; Zhang H.; Mykhailiuk P.; Merchant R.; Smith C.; Qin T.; Baran P.
Ultra-large library docking for discovering new chemotypes

Nature 2019, 566 (7743), 224-229

DOI: 10.1038/s41586-019-0917-9

Lyu J.; Wang S.; Balius T.; Singh I.; Levit A.; Moroz Y.; O'Meara M.; Che T.; Algaa E.; Tolmachova K.; Tolmachev A.; Shoichet B.; Roth B.; Irwin J.
Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki-Miyaura Reactions of Bromooxazole Building Blocks

Eur. J. Org. Chem. 2019, (18), 2884-2898

DOI: 10.1002/ejoc.201900032

Solomin V.; Radchenko D.; Slobodyanyuk E.; Geraschenko O.; Vashchenko B.; Grygorenko O.
Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group-A Model for yet Unknown Peptidases?

Molecules 2019, 24 (3), 572

DOI: 10.3390/molecules24030572

Komarov I.; Ishchenko A.; Hovtvianitsa A.; Stepanenko V.; Kharchenko S.; Bond A.; Kirby A.
Evolution of commercially available compounds for HTS

Drug Discovery Today 2019, 24 (2), 390-402

DOI: 10.1016/j.drudis.2018.10.016

Volochnyuk D.; Ryabukhin S.; Moroz Y; Savych O.; Chuprina A.; Horvath D.; Zabolotna Y.; Varnek A.; Judd D.
Low molecular weight supramolecular dehydroepiandrosterone-based gelators: Synthesis and molecular modeling study

New J. Chem. 2019, 43 (33), 13112-13121

DOI: 10.1039/c9nj01390c

Zhikol O.; Shishkina S.; Lipson V.; Semenenko A.; Mazepa A.; Borisov A.; Mateychenko P.
Difluorodiazoethane (CF2HCHN2 ): A New Reagent for the Introduction of the Difluoromethyl Group

Chem. Eur. J. 2019, 25 (24), 6053-6063

DOI: 10.1002/chem.201804953

Mykhailiuk P.; Koenigs R.
A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

Amino Acids 2019, 51 (2), 255-261

DOI: 10.1007/s00726-018-2660-1

Melnykov K.; Volochnyuk D.; Ryabukhin S.; Rusanov, E.; Grygorenko O.
3-((Hetera)cyclobutyl)azetidines, “Stretched” Analogues of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery

J. Org. Chem. 2019, 84 (3), 1363-1371

DOI: 10.1021/acs.joc.8b02822

Feskov I.; Chernykh A.; Kuchkovska Y.; Daniliuc C.; Kondratov I.; Grygorenko O.
Structure-Activity Relationships of Photoswitchable Diarylethene-Based β-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents

J. Med. Chem. 2018, 61 (23), 10793-10813

DOI: 10.1021/acs.jmedchem.8b01428

Babii O.; Afonin S.; Ishchenko A.; Schober T.; Negelia A.; Tolstanova G.; Garmanchuk L.; Ostapchenko L.; Komarov I.; Ulrich A.
Synthesis of 4-(2H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one via Ring-Switching Hydrazinolysis of 5-Ethoxymethylidenethiazolo [3,2-b][1,2,4]triazol-6-one

MolBank 2018, 4, 1022

DOI: 10.3390/M1022

Holota S.; Shylych Y.; Derkach H.; Karpenko O.; Gzella A.; Lesyk R.
Comparative effects of trifluoromethyl- and methyl-group substitutions in proline

New J. Chem. 2018, 42 (16), 13461-13470

DOI: 10.1039/c8nj02631a

Kubyshkin V.; Pridma S.; Budisa N.
Formation of hierarchically-ordered nanoporous silver foam and its electrocatalytic properties in reductive dehalogenation of organic compounds

New J. Chem. 2018, 42 (21), 17499-17512

DOI: 10.1039/C8NJ03460E

Mishura A.; Lytvynenko A.; Gavrilenko K.; Baranchikov A.; Grabovaya N.; Kiskin M.; Kolotilov S.
Synthesis and antitumor activities of new n-(5-benzylthiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides

Biopolym. Cell. 2018, 34 (1), 59-71

DOI: 10.7124/bc.000971

Ostapiuk Y.; Frolov D.; Vasylyschyn R.; Matiychuk V.
Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes

J. Org. Chem. 2018, 83 (12), 6275-6289

DOI: 10.1021/acs.joc.8b00077

Skalenko Y.; Druzhenko T.; Denisenko A.; Samoilenko M.; Dacenko O.; Trofymchuk S.; Grygorenko O.; Tolmachev A.; Mykhailiuk P.
Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking

Org. Biomol. Chem. 2018, 16 (44), 8559-8564

DOI: 10.1039/C8OB02428F

Strizhak A.; Sharma K.; Babii O.; Afonin S.; Ulrich A.; Komarov I.; Spring D.
Synthesis of benzofuro[3,2-b]furo[2,3-d]pyridin-4(5H)-ones, derivatives of a novel heterocyclic system

Heterocycl. Commun. 2018, 24 (4), 177-181

DOI: 10.1515/hc-2017-0143

Yahodkina-Yakovenko M.; Bol'but A.; Vovk M.
Synthesis of azabicyclo[n.1.0]alkane-derived bifunctional building blocks via the Corey–Chaykovsky cyclopropanation

Tetrahedron Lett. 2018, 59 (52), 4611-4615

DOI: 10.1016/j.tetlet.2018.11.047

Yarmoliuk D.; Serhiichuk D.; Smyrnov V.; Tymtsunik A.; Hryshchuk O.; Kuchkovska Y.; Grygorenko O.
One-Pot Synthesis of 6-Aminopyrido[2,3-d]pyrimidin-7-ones

Eur. J. Org. Chem. 2018, 46, 6519-6523

DOI: 10.1002/ejoc.201801204

Zinchenko A.; Muzychka L.; Kucher O.; Sadkova I.; Mykhailiuk P.; Smolii O.
Synthesis of 4-Hetarylisoxazoles from Amino Acid-Derived Halogenoximes and Push-Pull Enamines

Eur. J. Org. Chem. 2018, 40, 5585-5595

DOI: 10.1002/ejoc.201800753

Chalyk B.; Hrebeniuk K.; Gavrilenko K.; Kulik I.; Rozhenko A.; Volochnyuk D.; Liashuk O.; Grygorenko O.
Regioselective synthesis of isoxazole and 1,2,4-oxadiazole-derived phosphonates via [3 + 2] cycloaddition

Org. Biomol. Chem. 2018, 16 (47), 9152-9164

DOI: 10.1039/C8OB02257G

Chalyk B.; Sosedko A.; Volochnyuk D.; Tolmachev A.; Gavrilenko K.; Liashuk O.; Grygorenko O.
Hetaryl Bromides Bearing SO2F Group - Versatile Substrates for Palladium-Catalyzed C-C Coupling Reactions

Eur. J. Org. Chem. 2018, 47, 6682-6692

DOI: 10.1002/ejoc.201801270

Cherepakha A.; Stepannikova K.; Vashchenko B.; Gorichko M.; Tolmachev A.; Grygorenko O.

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