Eur. J. Org. Chem. 2021, 2021 (47), 6511‑6523
DOI: 10.1002/ejoc.202100412
Merzhyievskyi D.; Shablykin O.; Shablykina O.; Kozytskiy A.; Rusanov E.; Moskvina V.; Brovarets V.
An approach for the synthesis of new 5-amino-4-cyanoxazoles with carboxylate group at the C-2 position, connected to the heterocycle directly or through an aliphatic linker, was developed. This process features readily available starting materials, simple operations, and good to high yields. Wide synthetic applicability of the obtained compounds was also successfully demonstrated by further modifications.