Emerging Building Blocks for Medicinal Chemistry: Recent Synthetic Advances

Emerging building blocks for medicinal chemistry are discussed, with a special focus on recent efforts towards their synthesis. Saturated (hetero)aliphatic boronates, sulfonyl fluorides, sulfinates, non-classical sp³-enriched benzene isosteres, bicyclic morpholine, piperidine, or piperazine analogues, as well as gem-difluorinated cycloalkanes (a deliberately selected example of emerging fluorinated motifs) are covered.