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Eur. J. Org. Chem. 2021, 2021 (47), 6591‑6603

DOI: 10.1002/ejoc.202100581

Fedyk A.; Slobodyanyuk E.; Stotska O.; Vashchenko B.; Volochnyuk D.; Sibgatulin D.; Tolmachev A.; Grygorenko O.

Multigram synthesis of saturated heterocyclic dimethylphosphine oxides (derivatives of azetidine, pyrrolidine, piperidine, and morpholine) – advanced building blocks for medicinal chemistry – as well as their physico-chemical properties (pKa, logP, and Sw) are disclosed.

 

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