Eur. J. Org. Chem. 2021, 2021 (47), 6591‑6603
DOI: 10.1002/ejoc.202100581
Fedyk A.; Slobodyanyuk E.; Stotska O.; Vashchenko B.; Volochnyuk D.; Sibgatulin D.; Tolmachev A.; Grygorenko O.
Multigram synthesis of saturated heterocyclic dimethylphosphine oxides (derivatives of azetidine, pyrrolidine, piperidine, and morpholine) – advanced building blocks for medicinal chemistry – as well as their physico-chemical properties (pKa, logP, and Sw) are disclosed.