Organic azides are an important class of synthetic building blocks commonly used for “Click Chemistry” via Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction.
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Our stock of azides contains over 1 100 building blocks having various residues:
We have developed the library of 380 diverse azides that can be used for click chemistry. The building blocks are supplied in DMSO solutions at 100 mM. Most popular library formats available for immediate supply are shown below. You can suggest your preferred format and also select your own set of azides.
Most popular library formats available for immediate supply
Catalog No.
AZD-380-X-100
Compounds
380
Plates
4
Amount
100 µL of 100 mM DMSO stock solutions
Format
96-well microplates, 96 compounds per plate
Our azide libraries have balanced profiles representing various types of azides ranging from aliphatic to heteroaromatic ones. These building blocks have been approved for parallel synthesis after tests conducted at Enamine. Many azides are rare and not available at the market, besides at Enamine. All building blocks can be resupplied in larger amounts in e.g. MTBE solutions allowing transportation by air.
380 Diverse Azides Profile
MW distribution for 380 Diverse Azides
Understanding the importance of the fast access to the diverse building blocks used in Click Chemistry, Enamine offers several collections of compounds providing access to many classes of organic fragments – heterocyclic rings, aromatic, heteroaromatic, aliphatic residues, functionalized by different functional groups.
Acetylenes for "Click Chemistry"
Molecular properties
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Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Carboxylic acids are the second largest building block category of Enamine’s stock (after amines); they are extensively used in the lab as precursors to many other compound classes. Enamine offers over 37 000 carboxylic acids from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel carboxylic acids that we design and synthesize in our labs.
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Novel carboxylic acids
Every month we synthesize hundreds of new carboxylic acids that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Scaffolds
Enamine’s stock collection can offer a wide range of scaffolds for drug design, being represented by bi- and trifunctional building blocks allowing for chemoselective modification.
Building blocks for parallel synthesis
Carboxylic acids have found a wide application in synthesis of compound libraries first of all because of smoothly running amide bond formation. Using our in-house developed reactivity filters we have selected a range of carboxylic acids that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of carboxylic acids can be easily shared on your request.
Building blocks and scaffolds for DNA-Encoded Library (DEL) synthesis
Design of the scaffolds for synthesis of DEL libraries should respect principle of orthogonal reactivity of the functional groups coupled with their relatively high reactivity allowing for smooth and selective reactions under mild reaction conditions. Only the right combination of functional groups allows using the compound in DEL synthesis. Enamine offers numerous DNA-compatible carboxylic acids with additional functional groups such as aldehyde, amino groups, halogens, etc.
Screening compounds and fragments
Screening compounds and fragments containing carboxyl function have special interest to drug discovery. They have improved probability for hit identification in the case of new and difficult targets, e.g. protein-protein interaction, due to binding affinity to so-called “hot-spot” amino acid residues. We offer special selections of carboxylic acids from Enamine’s screening compounds and fragment collection.
MADE carboxylic acids
Having synthesized thousands of carboxylic acids and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalog. We have gathered our ideas of such new building blocks in a database that can be shared on request.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Aryl halides are one of the most popular classes of functional compounds in medicinal chemistry. They have always been drawing synthetic chemists’ attention as beneficial reagents for arylation or for further aromatic core modification. Enamine offers over 21 000 aryl halides from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel aryl halides that we design and synthesize in our labs.
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Aryl halides
Item
Fluorinated
Five-membered rings
Six-membered rings
Bicyclic
Item
Bifunctional
Five-membered rings
Six-membered rings
Bicyclic
Novel aryl halides
Every month we synthesize nearly a hundred new aryl halides that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Scaffolds
Our aryl halides-based scaffolds are represented by a considerable number of building blocks with at least two variation points allowing selective chemical modification.
Building blocks for parallel synthesis
Aryl halides have found a wide application in synthesis of compound libraries first of all because of smoothly running arylation reactions, as well as palladium-catalyzed couplings. Using our in-house developed reactivity filters we have selected a range of aryl halides that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of aryl halides can be easily shared on your request.
Building blocks and scaffolds for DNA-Encoded Library (DEL) synthesis
Design of the scaffolds for synthesis of DEL libraries should respect principle of orthogonal reactivity of the functional groups coupled with their relatively high reactivity allowing for smooth and selective reactions under mild reaction conditions. Only the right combination of functional groups allows using the compound in DEL synthesis. Enamine offers numerous DNA-compatible aryl halides with additional functional groups such as carboxylic, amino groups, aldehydes, etc.
MADE aryl halides
Having synthesized thousands of aryl halides and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalog. We have gathered our ideas of such new building blocks in a database that can be shared on request.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Boronic acids, organoboronates and other related compounds have gained popularity in medicinal chemistry recently. Organoboron derivatives are commonly used reagents for C–C bond formation, either via classical palladium-mediated transformations or through other more recent coupling methods. Enamine offers over 2 000 organoboron derivatives from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel organoboron derivatives that we design and synthesize in our labs.
Boronic acids and their derivatives
Novel organoboron derivatives
Every month we synthesize dozens of new organoboron derivatives that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Building blocks for parallel synthesis
Organoboron derivatives have found a wide application in synthesis of compound libraries first of all because of smoothly running Suzuki–Miyaura C–C coupling reactions. Using our in-house developed reactivity filters we have selected a range of organoboron derivatives that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of organoboron derivatives can be easily shared on your request.
Screening compounds and fragments
Screening compounds and fragments containing boron are of particular interest to drug discovery as covalent modifiers selectively acting at serine residues in the active site of the biological target. We offer special selections of organoboron derivatives from Enamine’s fragment collection.
Organotrifluoroborates and MIDA boronates
Since boronic acids in some cases have limited self-stability, several synthetic equivalents are available for them. Being in line with this trend, we have prepared a subset of MIDA boronates and trifluoroborates for your research.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Importance of carbon-nitrogen bond formation using primary amines made them an object of interest in organic synthesis and drug discovery. Enamine offers over 37 000 primary amines from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel primary amines that we design and synthesize in our labs.
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Primary amines
Novel primary amines
Every month we synthesize hundreds of new primary amines that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Scaffolds
Our primary amines-based scaffolds are represented by a considerable number of building blocks with at least two variation points allowing selective chemical modification.
Building blocks for parallel synthesis
Primary amines have found a wide application in synthesis of compound libraries first of all because of smoothly running amide coupling, arylation, alkylation, reductive amination reactions etc. Using our in-house developed reactivity filters we have selected a range of primary amines that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of primary amines can be easily shared on your request.
MADE primary amines
Having synthesized thousands of primary amines and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalog. We have gathered our ideas of such new building blocks in a database that can be shared on request.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.