Boronic acids, organoboronates and other related compounds have gained popularity in medicinal chemistry recently. Organoboron derivatives are commonly used reagents for C–C bond formation, either via classical palladium-mediated transformations or through other more recent coupling methods. Enamine offers over 2 000 organoboron derivatives from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel organoboron derivatives that we design and synthesize in our labs.
Boronic acids and their derivatives
Novel organoboron derivatives
Every month we synthesize dozens of new organoboron derivatives that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Building blocks for parallel synthesis
Organoboron derivatives have found a wide application in synthesis of compound libraries first of all because of smoothly running Suzuki–Miyaura C–C coupling reactions. Using our in-house developed reactivity filters we have selected a range of organoboron derivatives that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of organoboron derivatives can be easily shared on your request.
Screening compounds and fragments
Screening compounds and fragments containing boron are of particular interest to drug discovery as covalent modifiers selectively acting at serine residues in the active site of the biological target. We offer special selections of organoboron derivatives from Enamine’s fragment collection.
Organotrifluoroborates and MIDA boronates
Since boronic acids in some cases have limited self-stability, several synthetic equivalents are available for them. Being in line with this trend, we have prepared a subset of MIDA boronates and trifluoroborates for your research.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
