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Boronic acids and their derivatives

Boronic acids, organoboronates and other related compounds have gained popularity in medicinal chemistry recently. Organoboron derivatives are commonly used reagents for C–C bond formation, either via classical palladium-mediated transformations or through other more recent coupling methods. Enamine offers over 1 900 organoboron derivatives from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel organoboron derivatives that we design and synthesize in our labs.

Boronic acids and their derivatives

 
Aliphatic
Aromatic
Small rings

Item

Original

Aliphatic


EN300-112860

Aromatic


EN300-139273

Small rings


EN300-254324

Item

Fluorinated

Aliphatic


EN300-214510

Aromatic


EN300-261415

Small rings


EN300-1608207

Item

Bifunctional

Aliphatic


EN300-191542

Aromatic


EN300-122818

Small rings


EN300-267466

Novel organoboron derivatives

Every month we synthesize dozens of new organoboron derivatives that we immediately commercialize in our catalogue available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.

Building blocks for parallel synthesis

Organoboron derivatives have found a wide application in synthesis of compound libraries first of all because of smoothly running Suzuki–Miyaura C–C coupling reactions. Using our in-house developed reactivity filters we have selected a range of organoboron derivatives that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of organoboron derivatives can be easily shared on your request.

Screening compounds and fragments

Screening compounds and fragments containing boron are of particular interest to drug discovery as covalent modifiers selectively acting at serine residues in the active site of the biological target. We offer special selections of organoboron derivatives from Enamine’s fragment collection.

Organotrifluoroborates and MIDA boronates

Since boronic acids in some cases have limited self-stability, several synthetic equivalents are available for them. Being in line with this trend, we have prepared a subset of MIDA boronates and trifluoroborates for your research.

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Library Synthesis

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