Aryl halides are one of the most popular classes of functional compounds in medicinal chemistry. They have always been drawing synthetic chemists’ attention as beneficial reagents for arylation or for further aromatic core modification. Enamine offers over 21 000 aryl halides from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel aryl halides that we design and synthesize in our labs.
Every month we synthesize nearly a hundred new aryl halides that we immediately commercialize in our catalogue available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Our aryl halides-based scaffolds are represented by a considerable number of building blocks with at least two variation points allowing selective chemical modification.
Aryl halides have found a wide application in synthesis of compound libraries first of all because of smoothly running arylation reactions, as well as palladium-catalyzed couplings. Using our in-house developed reactivity filters we have selected a range of aryl halides that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of aryl halides can be easily shared on your request.
Design of the scaffolds for synthesis of DEL libraries should respect principle of orthogonal reactivity of the functional groups coupled with their relatively high reactivity allowing for smooth and selective reactions under mild reaction conditions. Only the right combination of functional groups allows using the compound in DEL synthesis. Enamine offers numerous DNA-compatible aryl halides with additional functional groups such as carboxylic, amino groups, aldehydes, etc.
Having synthesized thousands of aryl halides and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalogue. We have gathered our ideas of such new building blocks in a database that can be shared on request.