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Conformationally Constrained Mono-Fluorinated Arginine as a Cationic Label for Solid-State 19F NMR Analysis of Membrane-Bound Peptide

Eur. J. Org. Chem. 2018, 27-28, 3826-3833

DOI: 10.1002/ejoc.201800473

Michurin O.; Tolmachova K.; Afonin S.; Babii O.; Grage S.; Ulrich A.; Komarov I.; Radchenko D.
Synthesis of Bi- and Polyfunctional Isoxazoles from Amino Acid Derived Halogenoximes and Active Methylene Nitriles

Eur. J. Org. Chem. 2018, 22, 2753-2761

DOI: 10.1002/ejoc.201800311

Chalyk B.; Hrebeniuk K.; Gavrilenko K.; Shablykin O.; Yanshyna O.; Bash D.; Mykhailiuk P.; Liashuk O.; Grygorenko O.
Following Ramachandran 2: exit vector plot (EVP) analysis of disubstituted saturated rings

New J. Chem. 2018, 42 (11), 8355-8365

DOI: 10.1039/C7NJ05015A

Grygorenko O.; Demenko D.; Volochnyuk D.; Komarov I.
Amino sulfonic acids, peptidosulfonamides and other related compounds

Tetrahedron 2018, 74 (13), 1355-1421

DOI: 10.1016/j.tet.2018.01.033

Grygorenko O.; Biitseva A.; Zhersh S.
Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery

Chem. Eur. J. 2018, 24 (21), 5444-5449

DOI: 10.1002/chem.201800193

Kirichok A.; Shton I.; Pishel I.; Zozulya S.; Borysko P.; Kubyshkin V.; Zaporozhets O.; Tolmachev A.; Mykhailiuk P.
[3+2] Cycloaddition of an Azomethyne Ylide and Vinyl Sulfonyl Fluorides ― an Approach to Pyrrolidine-3-sulfonyl Fluorides

Eur. J. Org. Chem. 2018, (22), 2870-2876

DOI: 10.1002/ejoc.201800521

Mykhalchuk V.; Yarmolchuk V.; Doroschuk R.; Tolmachev A.; Grygorenko O.
Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives

Tetrahedron Lett. 2018, 59 (5), 442-444

DOI: 10.1016/j.tetlet.2017.12.065

Yaremchuk I.; Muzychka L.; Smolii O.; Kucher O.; Shishkina S.
Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

RSC Adv. 2018, 8 (10), 5114-5118

DOI: 10.1039/C7RA13141K

Zheng Y.; Yu X.; Lv S.; Mykhailiuk P.; Ma Q.; Hai L.; Wu Y.
Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides

Chem. Eur. J. 2018, 24 (33), 8343-8349

DOI: 10.1002/chem.201801140

Zhersh S.; Blahun O.; Sadkova I.; Tolmachev A.; Moroz Y.; Mykhailiuk P.
Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks

Synthesis 2018, 50 (10), 1973-1978

DOI: 10.1055/s-0037-1609434

Grygorenko O.; Kurkunov M.; Levandovskiy I.; Tymtsunik A.
Synthesis of 8Н-pyrazolo[5',1':3,4]pyrazino[2,1-b]quinazolin-8-ones

Chem. Heterocycl. Compd. 2018, 53 (11), 1242-1247

DOI: 10.1016/j.tetlet.2016.01.094

Hrynyshyn Y.; Tsizorik N.; Musiychuk A.; Bol’but A.; Vovk M.
1-(Trimethylsilyl)vinyl MIDA Boronate: A Trifunctional C2 Building Block

Synthesis 2018, 50 (9), 1857-1861

DOI: 10.1055/s-0036-1591926

Ivon Y.; Voitenko Z.; Grygorenko O.
Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline

J. Org. Chem. 2018, 83 (3), 1394–1401

DOI: 10.1021/acs.joc.7b02910

Druzhenko T.; Skalenko Y.; Samoilenko M.; Denisenko A.; Zozulya S.; Borysko P.; Sokolenko M.; Tarasov A.; Mykhailiuk P.
4-Amino-2,3-dihydro-1λ6-isothiazole-1,1-dioxides and their chemical properties evaluation

Mol. Divers. 2018, 22 (4), 919–927

DOI: 10.1007/s11030-018-9848-x

Dyachenko M.; Dobrydnev A.; Volovenko Y.
[2+2]-Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes

J. Org. Chem. 2018, 83 (12), 6275-6289

DOI: 10.1021/acs.joc.8b00077

Skalenko Y.; Druzhenko T.; Denisenko A.; Samoilenko M.; Dacenko O.; Trofymchuk S.; Grygorenko O.; Tolmachev A.; Mykhailiuk P.
Straightforward hit identification approach in fragment-based discovery of bromodomain-containing protein 4 (BRD4) inhibitors

Bioorg. Med. Chem. 2018, 26 (12), 3399-3405

DOI: 10.1016/j.bmc.2018.05.010

Borysko P.; Moroz Y.; Vasylchenko O.; Hurmach V.; Starodubtseva A.; Stefanishena N.; Nesteruk K.; Zozulya S.; Kondratov I.; Grygorenko O.
Diels-Alder Reaction in the Synthesis of Fluorinated (Hetero)Aromatic Compounds

Eur. J. Org. Chem. 2018, (27-28)

DOI: 10.1002/ejoc.201800327

Kondratov I.; Tolmachova N.; Haufe G.
Preparation of 5-Fluoropyrazoles from Pyrazoles and N-Fluorobenzenesulfonimide (NFSI)

J. Org. Chem. 2018, 83 (6), 3265-3274

DOI: 10.1021/acs.joc.8b00199

Levchenko V.; Dmytriv Y.; Tymtsunik A.; Liubchak K.; Rudnichenko A.; Melnyk A.; Veselovych S.; Borodulin Y.; Otsalyuk O.; Tolmachev A.; Mykhailiuk P.
A bio-inspired approach to proline-derived 2,4-disubstituted oxazoles

Heterocycl. Commun. 2018, 24 (1), 11-17

DOI: 10.1515/hc-2017-0235

Slobodyanyuk E.; Artamonov O.; Kulik I.; Rusanov E.; Volochnyuk D.; Grygorenko O.
Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

Chem. Eur. J. , 2018, 24 (47)

DOI: 10.1002/chem.201705708

Bychek R.; Levterov V.; Sadkova I.; Tolmachev A. Mykhailiuk P.
An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries

ACS Comb. Sci. 2018, 20 (1), 35-43

DOI: 10.1021/acscombsci.7b00163

Bogolubsky A.; Moroz Y.; Savych O.; Pipko S.; Konovets A.; Platonov M.; Vasylchenko O.; Hurmach V.; Grygorenko O.
O-(α-Phenylethyl)hydroxylamine as a ‘chiral ammonia equivalent’: synthesis and resolution of 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids

Tetrahedron 2017, 28 (12), 1817-1822

DOI: 10.1016/j.tetasy.2017.10.027

Kleban I.; Tymtsunik A.; Rassukana Y.; Grygorenko O.
Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers

Biochim Biophys Acta Biomembr 2017, 1859 (12), 2505-2515

DOI: 10.1016/j.bbamem.2017.09.021

Babii O.; Afonin S.; Schober T.; Komarov I.; Ulrich A.
Scalable synthesis and properties of 7-methyl- 4-azaindole

Heterocycl. Commun. 2017, 23 (6), 449–453

DOI: 10.1515/hc-2017-0180

Subota A.; Volochnyuk D.; Gorlova A.; Grygorenko O.
Influence of the Synthesis Conditions and the Presence of Guest Molecules on the Structures of Coordination Polymers [Fe2MO(Piv)6(L) x ] n (L = 4,4′-Bipyridine, Bis(4-Pyridyl)ethane) with the Labile Crystal Lat

Russ. J. Coord. Chem. 2017, 43 (10), 619–629

DOI: 10.1134/s1070328417100086

Polunin R. A.; Kiskin M. A.; Gavrilenko K. S.; Imshennik V. K.; Maksimov Y. V.; Eremenko I. L.; Kolotilov S. V.
The addition of β-ketoacids to 4-(trifluoromethyl)pyrimidin- 2(1Н)-ones with decarboxylation: an effective method for the synthesis of 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones

Chem. Heterocycl. Compd. 2017, 53 (10), 1124–1127

DOI: 10.1007/s10593-017-2182-x

Tkachuk V. M.; Mel’nikov S. V.; Sukach V. A.; Vovk M. V.
Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists

Eur. J. Med. Chem. 2017, 140, 229–238

DOI: 10.1016/j.ejmech.2017.09.019

Krasavin M.; Lukin A.; Bakholdina A.; Zhurilo N.; Onopchenko O.; Borysko P.; Zozulya S.; Moore D.; Tikhonova I. G.
Chromatographic Separation of Racemates of Alcohols Using Porous Coordination Compounds of Zinc and Vanadium(IV) with Lactate and β-Cyclodextrin

Theor. Exp. Chem. 2017, 53 (3), 204-209

DOI: 10.1007/s11237-017-9517-7

Satska Y. A.; Komarova N. P.; Gavrilenko K. S.; Polunin R. A.; Manoylenko O. V.; Kolotilov S. V.
Design, Synthesis and Anti-inflammatory Activity of Derivatives 10-R-3-Aryl-6,7-dihydro-2H-[1,2,4] triazino[2,3-c]quinazolin-2-ones of Spiro-fused Cyclic Frameworks

Acta Chim. Slov. 2017, 64 (4), 902-910

DOI: 10.17344/acsi.2017.3575

Kolomoets O.; Voskoboynik O.; Antypenko O.; Berest G.; Nosulenko I.; Palchikov V.; Karpenko O.; Kovalenko S.
Evaluation of Efficient and Practical Methods for the Preparation of Functionalized Aliphatic Trifluoromethyl Ethers

Molecules 2017, 22 (5), 804

DOI: 10.3390/molecules22050804

Sokolenko T. M.; Dronkina M. I.; Magnier E.; Yagupolskii L. M.; Yagupolskii Y. L.
Difluoromethyl nitril oxide (CF2HCNO): overseen chemical reagent

Eur. J. Org. Chem. 2017, 27, 3935-3940

DOI: 10.1002/ejoc.201700764

Khutoryanskiy A.; Chalyk B.; Borysko P.; Kondratiuk A.; Mykhailiuk P.
Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids

Mol. Diver. 2017, 21 (2), 427-436

DOI: 10.1007/s11030-017-9737-8

Lozynskyi A.; Zasidko V.; Atamanyuk D.; Kaminskyy D.; Derkach H.; Karpenko O.; Ogurtsov V.; Kutsyk R.; Lesyk R.
A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

Nat. Chem. Biol. 2017, 13 (7), 771-778

DOI: 10.1038/nchembio.2382

Licciardello M. P.; Ringler A.; Markt P.; Klepsch F.; Lardeau C. H.; Sdelci S.; Schirghuber E.; Muller A. C.; Caldera M.; Wagner A.; Herzog R.; Penz T.; Schuster M.; Boidol B.; Durnberger G.; Folkvaljon Y.; Stattin P.; Ivanov V.; Colinge J.; Bock C.; Kratochwill K.; Menche J.; Bennett K. L.; Kubicek S.
A peptidyl-prolyl model study: How does the electronic effect influence the amide bond conformation?

J. Org. Chem. 2017, 82 (17), 8831-8841

DOI: 10.1021/acs.joc.7b00803

Mykhailiuk P. K.; Kubyshkin V.; Bach T.; Budisa N.
Heptafluoroisopropyl diazomethane (i-C3F7CHN2): in situ generation and synthesis of pyrazoles

Org. Biomol. Chem.
2017, 15 (35), 7243-7478

DOI: 10.1039/c7ob01579h

Mykhailiuk P. K.
Synthesis of N-nitroso CHF2-pyrazolines, and transformation into CHF2-isoxazolines and pyrazoles

Eur. J. Org. Chem. 2017, (41), 6114-6120

DOI: 10.1002/ejoc.201700803

Lebed P.; Fenneteau J.; Wu Y.; Cossy J.; Mykhailiuk P.
Selective 19F-labeling of functionalized carboxylic acids with difluoromethyl diazomethane (CF2HCHN2)

Chem. Eur. J. 2017, 23 (54), 13279-13283

DOI: 10.1002/chem.201703446

Mykhailiuk P.; Kishko I.; kubyshkin V.; Budisa N.; Cossy J.
Synthesis of spirocyclic pyrrolidines: advanced building blocks for drug discovery

Chem. Eur. J. 2017, 23 (66), 16782-16786

DOI: 10.1002/chem.201702362

Chalyk B.; Butko M.; Yanshyna O.; Gavrilenko K.; Druzhenko T.; Mykhailiuk P.
Photochemical synthesis of 3-azabicyclo[3.2.0]heptanes: advanced building blocks for drug discovery

J. Org. Chem. 2017, 82 (18), 9627-9636

DOI: 10.1021/acs.joc.7b01678

Denisenko A. V.; Druzhenko T.; Skalenko Y.; Samoilenko M.; Grygorenko O. O.; Zozulya S.; Mykhailiuk P. K.
Reduction of imidazolium salts – An approach to diazocines and diazocanes

Tetrahedron 2017, 73 (49), 6942-6953

DOI: 10.1016/j.tet.2017.10.053

Shvydenko T.; Nazarenko K.; Shvydenko K.; Boron S.; Gutov O.; Tolmachev A.; Kostyuk A.
Cyclobutyl-Containing Rigid Analogues of Threonine: Synthesis and Physical Chemical Properties

J. Org. Chem. ,2017, 82 (23), 12863-12868

DOI: 10.1021/acs.joc.7b02259

Feskov I. O.; Chernykh A. V.; Kondratov I. S.; Klyachina M.; Daniliuc C. G.; Haufe G.
Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones

Beilstein J. Org. Chem. 2017, 13, 2617-2625

DOI: 10.3762/bjoc.13.259

Melnykov S. V.; Pataman A. S.; Dmytriv Y. V.; Shishkina S. V.; Vovk M. V.; Sukach V. A.
Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery

Eur. J. Org. Chem. 2017, 31, 4530-4542

DOI: 10.1002/ejoc.201700536

Chalyk B.; Isakov A.; Butko M.; Hrebeniuk K.; Savych O.; Kucher O.; Gavrilenko K.; Druzhenko T.; Yarmolchuk V.; Zozulya S.; Mykhailiuk P.
Bicyclo[1.1.1]pentane-Derived Building Blocks for Click Chemistry

Eur. J. Org. Chem. 2017, (43), 6450-6456

DOI: 10.1002/ejoc.201701296

Kokhan S.; Valter Y. B.; Tymtsunik A.; Komarov I.; Grygorenko O. O.
Synthesis of functionalized 4-fluoropyridazines

Asian J. Org. Chem. 2017, 6 (7), 927-935

DOI: 10.1002/ajoc.201700216

Feraldi-Xypolia A.; Fredj G.; Tran G.; Tsuchiya T.; Vors J.-P.; Mykhailiuk P.; Gomez Pardo D.; Cossy J.
An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates

Synthesis 2017, 49 (14), 3112-3117

DOI: 10.1055/s-0036-1588785

Grygorenko O.; Sokolenko Y.; Ostapchuk E.; Artemenko A.
CF3S(O)n-containing enaminones as precursors for the synthesis of pyrimidine-4(3H)-ones

Tetrahedron Lett. 2017, 58 (13), 1308‑1311

DOI: 10.1016/j.tetlet.2017.02.046

Sokolenko L. V.; Yagupolskii Y. L.; Kumanetska L. S.; Marrot J.; Magnier E.; Lipetskij V. O.; Kalinin I. V.
Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR

Biophys. J. 2017, 112 (4), 630-642

DOI: 10.1016/j.bpj.2016.12.040

Grage S. L.; Sani M.-A.; Cheneval O.; Henriques S. T.; Schalck C.; Heinzmann R.; Mylne J. S.; Mykhailiuk P. K.; Afonin S.; Komarov I. V.; Separovic F.; Craik D. J.; Ulrich A. S.
Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acids

Org. Biomol. Chem. 2017, 15 (3), 672-679

DOI: 10.1039/c6ob02436j

Kondratov I. S.; Logvinenko I. G.; Tolmachova N. A.; Morev R. N.; Kliachyna M. A.; Clausen F.; Daniliuc C. G.; Haufe G.
1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

Angew. Chem. 2017, 129 (30), 8865–8869

DOI: 10.1002/ange.201703801

Mykhailiuk P.; Kirichok A.; Shton I.; Kliachyna M.; Pishel I.

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