Publications

Straightforward hit identification approach in fragment-based discovery of bromodomain-containing protein 4 (BRD4) inhibitors

Bioorg. Med. Chem. 2018, 26 (12), 3399-3405

DOI: 10.1016/j.bmc.2018.05.010

Borysko P.; Moroz Y.; Vasylchenko O.; Hurmach V.; Starodubtseva A.; Stefanishena N.; Nesteruk K.; Zozulya S.; Kondratov I.; Grygorenko O.

Diels-Alder Reaction in the Synthesis of Fluorinated (Hetero)Aromatic Compounds

Eur. J. Org. Chem. 2018, (27-28)

DOI: 10.1002/ejoc.201800327

Kondratov I.; Tolmachova N.; Haufe G.

Preparation of 5-Fluoropyrazoles from Pyrazoles and N-Fluorobenzenesulfonimide (NFSI)

J. Org. Chem. 2018, 83 (6), 3265-3274

DOI: 10.1021/acs.joc.8b00199

Levchenko V.; Dmytriv Y.; Tymtsunik A.; Liubchak K.; Rudnichenko A.; Melnyk A.; Veselovych S.; Borodulin Y.; Otsalyuk O.; Tolmachev A.; Mykhailiuk P.

A bio-inspired approach to proline-derived 2,4-disubstituted oxazoles

Heterocycl. Commun. 2018, 24 (1), 11-17

DOI: 10.1515/hc-2017-0235

Slobodyanyuk E.; Artamonov O.; Kulik I.; Rusanov E.; Volochnyuk D.; Grygorenko O.

Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

Chem. Eur. J. , 2018, 24 (47)

DOI: 10.1002/chem.201705708

Bychek R.; Levterov V.; Sadkova I.; Tolmachev A. Mykhailiuk P.

An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries

ACS Comb. Sci. 2018, 20 (1), 35-43

DOI: 10.1021/acscombsci.7b00163

Bogolubsky A.; Moroz Y.; Savych O.; Pipko S.; Konovets A.; Platonov M.; Vasylchenko O.; Hurmach V.; Grygorenko O.

O-(α-Phenylethyl)hydroxylamine as a ‘chiral ammonia equivalent’: synthesis and resolution of 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids

Tetrahedron 2017, 28 (12), 1817-1822

DOI: 10.1016/j.tetasy.2017.10.027

Kleban I.; Tymtsunik A.; Rassukana Y.; Grygorenko O.

Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers

Biochim Biophys Acta Biomembr 2017, 1859 (12), 2505-2515

DOI: 10.1016/j.bbamem.2017.09.021

Babii O.; Afonin S.; Schober T.; Komarov I.; Ulrich A.

Scalable synthesis and properties of 7-methyl- 4-azaindole

Heterocycl. Commun. 2017, 23 (6), 449–453

DOI: 10.1515/hc-2017-0180

Subota A.; Volochnyuk D.; Gorlova A.; Grygorenko O.

Influence of the Synthesis Conditions and the Presence of Guest Molecules on the Structures of Coordination Polymers [Fe₂MO(Piv)₆(L) _x ] _n (L = 4,4′-Bipyridine, Bis(4-Pyridyl)ethane) with the Labile Crystal Lat

Russ. J. Coord. Chem. 2017, 43 (10), 619–629

DOI: 10.1134/s1070328417100086

Polunin R. A.; Kiskin M. A.; Gavrilenko K. S.; Imshennik V. K.; Maksimov Y. V.; Eremenko I. L.; Kolotilov S. V.

The addition of β-ketoacids to 4-(trifluoromethyl)pyrimidin- 2(1Н)-ones with decarboxylation: an effective method for the synthesis of 4-(2-oxoalkyl)-6-(trifluoromethyl)-3,4-dihydropyrimidin-2-ones

Chem. Heterocycl. Compd. 2017, 53 (10), 1124–1127

DOI: 10.1007/s10593-017-2182-x

Tkachuk V. M.; Mel’nikov S. V.; Sukach V. A.; Vovk M. V.

Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists

Eur. J. Med. Chem. 2017, 140, 229–238

DOI: 10.1016/j.ejmech.2017.09.019

Krasavin M.; Lukin A.; Bakholdina A.; Zhurilo N.; Onopchenko O.; Borysko P.; Zozulya S.; Moore D.; Tikhonova I. G.

Chromatographic Separation of Racemates of Alcohols Using Porous Coordination Compounds of Zinc and Vanadium(IV) with Lactate and β-Cyclodextrin

Theor. Exp. Chem. 2017, 53 (3), 204-209

DOI: 10.1007/s11237-017-9517-7

Satska Y. A.; Komarova N. P.; Gavrilenko K. S.; Polunin R. A.; Manoylenko O. V.; Kolotilov S. V.

Design, Synthesis and Anti-inflammatory Activity of Derivatives 10-R-3-Aryl-6,7-dihydro-2H-[1,2,4] triazino[2,3-c]quinazolin-2-ones of Spiro-fused Cyclic Frameworks

Acta Chim. Slov. 2017, 64 (4), 902-910

DOI: 10.17344/acsi.2017.3575

Kolomoets O.; Voskoboynik O.; Antypenko O.; Berest G.; Nosulenko I.; Palchikov V.; Karpenko O.; Kovalenko S.

Evaluation of Efficient and Practical Methods for the Preparation of Functionalized Aliphatic Trifluoromethyl Ethers

Molecules 2017, 22 (5), 804

DOI: 10.3390/molecules22050804

Sokolenko T. M.; Dronkina M. I.; Magnier E.; Yagupolskii L. M.; Yagupolskii Y. L.

Difluoromethyl nitril oxide (CF₂HCNO): overseen chemical reagent

Eur. J. Org. Chem. 2017, 27, 3935-3940

DOI: 10.1002/ejoc.201700764

Khutoryanskiy A.; Chalyk B.; Borysko P.; Kondratiuk A.; Mykhailiuk P.

Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids

Mol. Diver. 2017, 21 (2), 427-436

DOI: 10.1007/s11030-017-9737-8

Lozynskyi A.; Zasidko V.; Atamanyuk D.; Kaminskyy D.; Derkach H.; Karpenko O.; Ogurtsov V.; Kutsyk R.; Lesyk R.

A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

Nat. Chem. Biol. 2017, 13 (7), 771-778

DOI: 10.1038/nchembio.2382

Licciardello M. P.; Ringler A.; Markt P.; Klepsch F.; Lardeau C. H.; Sdelci S.; Schirghuber E.; Muller A. C.; Caldera M.; Wagner A.; Herzog R.; Penz T.; Schuster M.; Boidol B.; Durnberger G.; Folkvaljon Y.; Stattin P.; Ivanov V.; Colinge J.; Bock C.; Kratochwill K.; Menche J.; Bennett K. L.; Kubicek S.

A peptidyl-prolyl model study: How does the electronic effect influence the amide bond conformation?

J. Org. Chem. 2017, 82 (17), 8831-8841

DOI: 10.1021/acs.joc.7b00803

Mykhailiuk P. K.; Kubyshkin V.; Bach T.; Budisa N.

Heptafluoroisopropyl diazomethane (i-C₃F₇CHN₂): in situ generation and synthesis of pyrazoles

Org. Biomol. Chem.
2017, 15 (35), 7243-7478

DOI: 10.1039/c7ob01579h

Mykhailiuk P. K.

Synthesis of N-nitroso CHF₂-pyrazolines, and transformation into CHF₂-isoxazolines and pyrazoles

Eur. J. Org. Chem. 2017, (41), 6114-6120

DOI: 10.1002/ejoc.201700803

Lebed P.; Fenneteau J.; Wu Y.; Cossy J.; Mykhailiuk P.

Selective ¹⁹F-labeling of functionalized carboxylic acids with difluoromethyl diazomethane (CF₂HCHN₂)

Chem. Eur. J. 2017, 23 (54), 13279-13283

DOI: 10.1002/chem.201703446

Mykhailiuk P.; Kishko I.; kubyshkin V.; Budisa N.; Cossy J.

Synthesis of spirocyclic pyrrolidines: advanced building blocks for drug discovery

Chem. Eur. J. 2017, 23 (66), 16782-16786

DOI: 10.1002/chem.201702362

Chalyk B.; Butko M.; Yanshyna O.; Gavrilenko K.; Druzhenko T.; Mykhailiuk P.

Photochemical synthesis of 3-azabicyclo[3.2.0]heptanes: advanced building blocks for drug discovery

J. Org. Chem. 2017, 82 (18), 9627-9636

DOI: 10.1021/acs.joc.7b01678

Denisenko A. V.; Druzhenko T.; Skalenko Y.; Samoilenko M.; Grygorenko O. O.; Zozulya S.; Mykhailiuk P. K.

Reduction of imidazolium salts – An approach to diazocines and diazocanes

Tetrahedron 2017, 73 (49), 6942-6953

DOI: 10.1016/j.tet.2017.10.053

Shvydenko T.; Nazarenko K.; Shvydenko K.; Boron S.; Gutov O.; Tolmachev A.; Kostyuk A.

Cyclobutyl-Containing Rigid Analogues of Threonine: Synthesis and Physical Chemical Properties

J. Org. Chem. ,2017, 82 (23), 12863-12868

DOI: 10.1021/acs.joc.7b02259

Feskov I. O.; Chernykh A. V.; Kondratov I. S.; Klyachina M.; Daniliuc C. G.; Haufe G.

Regioselective decarboxylative addition of malonic acid and its mono(thio)esters to 4-trifluoromethylpyrimidin-2(1H)-ones

Beilstein J. Org. Chem. 2017, 13, 2617-2625

DOI: 10.3762/bjoc.13.259

Melnykov S. V.; Pataman A. S.; Dmytriv Y. V.; Shishkina S. V.; Vovk M. V.; Sukach V. A.

Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery

Eur. J. Org. Chem. 2017, 31, 4530-4542

DOI: 10.1002/ejoc.201700536

Chalyk B.; Isakov A.; Butko M.; Hrebeniuk K.; Savych O.; Kucher O.; Gavrilenko K.; Druzhenko T.; Yarmolchuk V.; Zozulya S.; Mykhailiuk P.

Bicyclo[1.1.1]pentane-Derived Building Blocks for Click Chemistry

Eur. J. Org. Chem. 2017, (43), 6450-6456

DOI: 10.1002/ejoc.201701296

Kokhan S.; Valter Y. B.; Tymtsunik A.; Komarov I.; Grygorenko O. O.

Synthesis of functionalized 4-fluoropyridazines

Asian J. Org. Chem. 2017, 6 (7), 927-935

DOI: 10.1002/ajoc.201700216

Feraldi-Xypolia A.; Fredj G.; Tran G.; Tsuchiya T.; Vors J.-P.; Mykhailiuk P.; Gomez Pardo D.; Cossy J.

An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates

Synthesis 2017, 49 (14), 3112-3117

DOI: 10.1055/s-0036-1588785

Grygorenko O.; Sokolenko Y.; Ostapchuk E.; Artemenko A.

CF₃S(O)_n-containing enaminones as precursors for the synthesis of pyrimidine-4(3H)-ones

Tetrahedron Lett. 2017, 58 (13), 1308‑1311

DOI: 10.1016/j.tetlet.2017.02.046

Sokolenko L. V.; Yagupolskii Y. L.; Kumanetska L. S.; Marrot J.; Magnier E.; Lipetskij V. O.; Kalinin I. V.

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR

Biophys. J. 2017, 112 (4), 630-642

DOI: 10.1016/j.bpj.2016.12.040

Grage S. L.; Sani M.-A.; Cheneval O.; Henriques S. T.; Schalck C.; Heinzmann R.; Mylne J. S.; Mykhailiuk P. K.; Afonin S.; Komarov I. V.; Separovic F.; Craik D. J.; Ulrich A. S.

Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF₃O-containing analogue of natural lipophilic amino acids

Org. Biomol. Chem. 2017, 15 (3), 672-679

DOI: 10.1039/c6ob02436j

Kondratov I. S.; Logvinenko I. G.; Tolmachova N. A.; Morev R. N.; Kliachyna M. A.; Clausen F.; Daniliuc C. G.; Haufe G.

1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

Angew. Chem. 2017, 129 (30), 8865–8869

DOI: 10.1002/ange.201703801

Mykhailiuk P.; Kirichok A.; Shton I.; Kliachyna M.; Pishel I.

Diphytanoyl lipids as model systems for studying membrane-active peptides

Biochim. Biophys. Acta 2017, 1859 (10), 1828‑1837

DOI: 10.1016/j.bbamem.2017.06.003

Kara S.; Afonin S.; Babii O.; Tkachenko A. N.; Komarov I. V.; Ulrich A. S.

Synthesis of new triazolo[1,5-b][2,4]benzodiazepines via tandem cyclization of o-(azidomethyl)benzoates with cyanoacetamides

Monatsh. Chem. 2017, 148 (6), 1035-1041

DOI: 10.1007/s00706-016-1905-5

Yakovenko G.; Yagodkina M.; Bol’but A.; Shishkina S.; Vovk M. V.

trans-Aconitic acid-based hetero-Diels-Alder reaction in the synthesis of thiopyrano[2,3-d][1,3]thiazole derivatives

Tetrahedron Lett. 2017, 58 (18), 1751-1754

DOI: 10.1016/j.tetlet.2017.03.062

Zelisko N.; Karpenko O.; Muzychenko V.; Gzella A.; Grellier P.; Lesyk R.

Synthesis of a series of tetraminic acid sulfone analogs

Monatsh. Chem. 2017, 148 (5), 939-946

DOI: 10.1007/s00706-016-1884-6

Popova M.; Dobrydnev A.; Dyachenko M.; Duhayon C.; Listunov D.; Volovenko Y.

Synthesis of 1,6-diamino-2-imino-2,3-dihydropyrimidin-4(1Н)-one and preliminary study of its two- and three-component reactions

Chem. Heterocycl. Compd. 2017, 53 (4), 484‑490

DOI: 10.1007/s10593-017-2078-9

Zviagin I.; Zhelavskyi O.; Shishkina S.; Musatov V.; Borisov A.; Chebanov V.

Intramolecular functional group differentiation as a strategy for the synthesis of bridged bicyclic β-amino acids

RSC Adv. 2016, 6 (27), 22737-22748

DOI: 10.1039/C6RA01548D

Tymtsunik A. V.; Kokhan S. O.; Ivon Y. M.; Komarov I. V.; Grygorenko O. O.

3,4-Bis-phosphanyl-1H-pyrrole derivatives via direct electrophilic phosphanylation of 1-tert-butyl-1H-pyrrole

Tetrahedron Lett. 2016, 57 (12), 1382-1384

DOI: 10.1016/j.tetlet.2016.02.069

Smaliy R. V.; Chaykovskaya A. A.; Dmitriv Y. V.; Smal V. M.; Shtil N. A.; Kostyuk A. N.

Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery

Tetrahedron 2017, 73 (6), 750‑757

DOI: 10.1016/j.tet.2016.12.052

Tereshchenko A. D.; Myronchuk J. S.; Leitchenko L. D.; Knysh I. V.; Tokmakova G. O.; Litsis O. O.; Tolmachev A.; Liubchak K.; Mykhailiuk P.

Synthesis of Fluorinated Oxazoles by Oxidative Cyclization of Fluorinated Enamides

J. Fluorine Chem. 2017, 196, 88-97

DOI: 10.1016/j.jfluchem.2016.09.014

Shishlyk O.; Shcherbatiuk A.; Iminov R.; Tverdokhlebov A.; Tolmachev A.; Mykhailiuk P.; Biitseva A.

Synthesis of CF₂H-pyrazolines by [3+2]-cycloaddition between CF₂HCHN₂ and electron-deficient alkenes

Eur. J. Org. Chem. 2017, 2, 266-270

DOI: 10.1002/ejoc.201601462

Li J.; Yu X.-L.; Cossy J.; Lv S.-Y.; Zhang H.-L.; Su F.; Hai L.; Mykhailiuk P.; Wu Y.

Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835

Eur. J. Med. Chem. 2017, 127, 357-368

DOI: 10.1016/j.ejmech.2017.01.005

Krasavin M.; Lukin A.; Bagnyukova D.; Zhurilo N.; Golovanov A.; Zozulya S.; Zahanich I.; Moore D.; Tikhonova I. G.

Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles

ACS Comb. Sci. 2016, 18 (10), 616-624

DOI: 10.1021/acscombsci.6b00103

Tolmachev A.; Bogolubsky A. V.; Pipko S. E.; Grishchenko A. V.; Ushakov D. V.; Zhemera A. V.; Viniychuk O. O.; Konovets A. I.; Zaporozhets O. A.; Mykhailiuk P. K.; Moroz Y. S.

Reactivity of 5-endo-hydroxy-4-azatricyclo[5.2.1.02,6]dec-8-en-3-ones and their isomerization initiated by acids and bases

Russ. J. Org. Chem. 2016, 52 (5), 661-669

DOI: 10.1134/s1070428016050080

Tkachenko I. V.; Tarabara I. N.; Omel’chenko I. V.; Pal’chikov V. A.