search
Login Form

Publications

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes

Org. Biomol. Chem. 2015, 13 (11), 3438-3445

DOI: 10.1039/C4OB02670E

Mykhailiuk P. K.

In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes

Angew. Chem. Int. Ed. 2015, 54 (22), 6558‑6561

DOI: 10.1002/anie.201501529

Mykhailiuk P. K.

Synthesis and studies on gem-fluorinated 2-azabicyclo[n.1.0]alkanes

J. Fluorine Chem. 2015, 175 73-83

DOI: 10.1016/j.jfluchem.2015.03.008

Kubyshkin V.; Kheylik Y.; Mykhailiuk P. K.

γ-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state 19F-NMR peptide studies

Org. Biomol. Chem. 2015, 13 (11), 3171-3181

DOI: 10.1039/C5OB00034C

Kubyshkin V.; Afonin S.; Kara S.; Budisa N.; Mykhailiuk P. K.; Ulrich A. S.

Synthesis of Trifluoromethyl-Containing Polysubstituted Aromatic Compounds by Diels-Alder Reaction of Ethyl 3-Benzamido-2-oxo-6-(trifluoromethyl)-2H-pyran-5-carboxylate

Eur. J. Org. Chem. 2015, 11, 2482-2491

DOI: 10.1002/ejoc.201500032

Kondratov I. S.; Tolmachova N. A.; Dolovanyuk V. G.; Gerus I. I.; Daniliuc C.-G.; Haufe G.

Radical Reactions of Alkyl 2-Bromo-2,2-difluoroacetates with Vinyl Ethers: “Omitted” Examples and Application for the Synthesis of 3,3-Difluoro-GABA

J. Org. Chem. 2015, 80 (24), 12258-11264

DOI: 10.1021/acs.joc.5b02171

Kondratov I. S.; Bugera M. Y.; Tolmachova N. A.; Posternak G. G.; Daniliuc C. G.; Haufe G.

The Most Reactive Amide As a Transition-State Mimic For cis-trans Interconversion

J. Am. Chem. Soc. 2015, 137 (2), 926-930

DOI: 10.1021/ja511460a

Komarov I. V.; Yanik S.; Ishchenko A. Y.; Davies J. E.; Goodman J. M.; Kirby A. J.

Synthesis of a 2,5-Diazabicyclo[2.2.1]heptane-Derived α,β-Diamino Acid

Synthesis 2015, 26 (08), 1123-1130

DOI: 10.1055/s-0034-1380116

Ivon Y. M.; Tymtsunik A. V.; Komarov I. V.; Shishkin O. V.; Grygorenko O. O.

An Expedient and Practical Approach to Functionalized 3-Aza-, 3-Oxa-, and 3-Thiabicyclo[3.3.1]nonane Systems

Synthesis 2015, 47 (03), 367-367

DOI: 10.1055/s-0034-1379456

Ishchenko A. Y.; Yanik S.; Rusanov E. B.; Komarov I. V.; Kirby A. J.

Multigram Synthesis of Fluoroalkyl-Substituted Pyrazole-4-carboxylic Acids

Eur. J. Org. Chem. 2015, 4, 886-891

DOI: 10.1002/ejoc.201403295

Iminov R. T.; Mashkov A. V.; Vyzir I. I.; Chalyk B. A.; Tverdokhlebov A. V.; Mykhailiuk P. K.; Babichenko L. N.; Tolmachev A. A.; Volovenko Y. M.; Biitseva A.; Shishkin O. V.; Shishkina S. V.

Design, Synthesis, and Characterization of SO2-Containing Azabicyclo[3.n.1]alkanes: Promising Building Blocks for Drug Discovery

Org. Lett. 2015, 17 (8), 1922-1925

DOI: 10.1021/acs.orglett.5b00608

Druzhenko T.; Denisenko O.; Kheylik Y.; Zozulya S.; Shishkina S. S.; Tolmachev A.; Mykhailiuk P. K.

Synthesis of [1,2]dithiolo[3,4-b]pyridines via the reaction of dithiomalondianilide with arylmethylidenemalononitriles

Chem. Heterocycl. Compd. 2015, 51 (4), 389‑392

DOI: 10.1007/s10593-015-1713-6

Dotsenko V.; Krivokolysko S.; Frolov K.; Chigorina E.; Polovinko V.; Dmitrienko A.; Bushmarinov I.

Synthesis and Structural Analysis of Angular Monoprotected Diamines Based on Spiro[3.3]heptane Scaffold

J. Org. Chem. 2015, 80 (8), 3974-3981

DOI: 10.1021/acs.joc.5b00323

Chernykh A. V.; Radchenko D. S.; Grygorenko O. O.; Daniliuc C. G.; Volochnyuk D. M.; Komarov I. V.

Synthesis and Physicochemical Properties of 3-Fluorocyclobutylamines

Eur. J. Org. Chem. 2015, 29, 6466-6471

DOI: 10.1002/ejoc.201500746

Chernykh A. V.; Radchenko D. S.; Chernykh A. V.; Kondratov I. S.; Tolmachova N. A.; Datsenko O. P.; Kurkunov M. A.; Zozulya S. X.; Kheylik Y. P.; Bartels K.; Daniliuc C. G.; Haufe G.

Novel approach for the synthesis of N-unsubstituted 2,3,5,6-tetrahydro-4H-2,6-methano-1,3-benzoxazocine-4-thiones

Chem. Heterocycl. Compd. 2015, 51 (7), 678‑681

DOI: 10.1007/s10593-015-1756-8

Borisov A. V.; Kovalenko S. S.; Kovalenko S. M.

2,2,2-Trifluoroethyl Chlorooxoacetate – Universal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides

ACS Comb. Sci. 2015, 17 (10), 615-622

DOI: 10.1021/acscombsci.5b00091

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Pipko S. E.; Zhemera A. V.; Konovets A. I.; Stepaniuk O. O.; Myronchuk I. S.; Dmytriv Y. V.; Doroschuk R. A.; Zaporozhets O. A.; Tolmachev A.

One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones

ACS Comb. Sci. 2015, 17 (6), 348-354

DOI: 10.1021/acscombsci.5b00024

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Ostapchuk E. N.; Rudnichenko A. V.; Dmytriv Y. V.; Bondar A. N.; Zaporozhets O. A.; Pipko S. E.; Doroschuk R. A.; Babichenko L. N.; Konovets A. I.; Tolmachev A.

Facile one-pot synthesis of 4-substituted semicarbazides

RSC Adv. 2015, 5 (2), 1063-1069

DOI: 10.1039/C4RA12425A

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Dmytriv Y. V.; Pipko S. E.; Babichenko L. N.; Konovets A. I.; Tolmachev A.

Design and Synthesis of Novel 19F-Amino Acid: A Promising 19F NMR Label for Peptide Studies

Org. Lett. 2015, 17 (2), 226-229

DOI: 10.1021/ol503300m

Bandak D.; Babii O.; Vasiuta R.; Komarov I. V.; Mykhailiuk P. K.

Synthesis of 1-(pyrrolidin-2-ylmethyl)-1H-azoles and their piperidine-derived homologues

Cent. Eur. J. Chem. 2014, 12 (1), 67-73

DOI: 10.2478/s11532-013-0344-y

Zhersh S.; Karpenko O.; Ripenko V.; Tolmachev A.; Grygorenko O.

Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles

Synthesis 2014, 46 (09), 1254-1260

DOI: 10.1055/s-0033-1340840

Yarmoliuk D. V.; Arkhipov V. V.; Stambirskyi M. V.; Dmytriv Y. V.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.

Convenient synthesis of enantiopure (R-) and (S-)-3-fluoro-3-aminomethylpyrrolidines

Tetrahedron 2014, 70 (18), 3011-3017

DOI: 10.1016/j.tet.2014.03.002

Yarmolchuk V. S.; Mykhalchuk V. L.; Mykhailiuk P. K.

Synthesis of Boc-protected 4,5-methano-β-proline

Tetrahedron Lett. 2014, 55 (22), 3312-3315

DOI: 10.1016/j.tetlet.2014.04.038

Tymtsunik A. V.; Ivon Y. M.; Komarov I. V.; Grygorenko O. O.

Gram-Scale Synthesis of 3,5-Methanonipecotic Acid, a Nonchiral Bicyclic β-Amino Acid

Synlett 2014, 25 (03), 355-358

DOI: 10.1055/s-0033-1340322

Tymtsunik A. V.; Bilenko V. A.; Grygorenko O. O.; Komarov I. V.

Design and Synthesis of a Monofluoro-Substituted Aromatic Amino Acid as a Conformationally Restricted 19F NMR Label for Membrane-Bound Peptides

Eur. J. Org. Chem. 2014, 17, 3584-3591

DOI: 10.1002/ejoc.201301737

Tkachenko A. N.; Mykhailiuk P. K.; Radchenko D. S.; Babii O.; Afonin S.; Ulrich A. S.; Komarov I. V.

How Accurately Can We Predict the Melting Points of Drug-like Compounds?

J. Chem. Inf. Model. , 2014, 54 (12), 3320-3329

DOI: 10.1021/ci5005288

Tetko I. V.; Sushko Y.; Novotarskyi S.; Patiny L.; Kondratov I.; Petrenko A. E.; Charochkina L.; Asiri A. M.

Control of Regio- and Enantioselectivity in the Asymmetric Organocatalytic Addition of Acetone to 4-(Trifluoromethyl)pyrimidin-2(1H)-ones

Eur. J. Org. Chem. , 2014, (7), 1452-1460

DOI: 10.1002/ejoc.201301542

Sukach V. A.; Tkachuk V. M.; Shoba V. M.; Pirozhenko V. V.; Rusanov E. B.; Chekotilo A. A.; Röschenthaler G. V.; Vovk M. V.

One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in situ: Optimized Synthesis of Tris(trifluoromethyl)pyrazole

Eur. J. Org. Chem. , 2014, 12, 2487-2495

DOI: 10.1002/ejoc.201301852

Slobodyanyuk E. Y.; Artamonov O. S.; Shishkin O. V.; Mykhailiuk P. K.

Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core

Eur. J. Med. Chem. , 2014, 84 160-172

DOI: 10.1016/j.ejmech.2014.07.023

Sarnpitak P.; Mujumdar P.; Morisseau C.; Hwang S. H.; Hammock B.; Iurchenko V.; Zozulya S.; Gavalas A.; Geronikaki A.; Ivanenkov Y.; Krasavin M.

Toward Lead-Oriented Synthesis: One-Pot Version of Castagnoli Condensation with Nonactivated Alicyclic Anhydrides

ACS Comb. Sci. , 2014, 16 (3), 146-153

DOI: 10.1021/co4001277

Ryabukhin S. V.; Panov D. M.; Granat D. S.; Ostapchuk E. N.; Kryvoruchko D. V.; Grygorenko O. O.

Three-Component Synthesis of 4-Aroyl-2(1),4,5,7-Tetrahydropyrazolo[3,4-b]Pyridin-6-Ones and Their Properties

Chem. Heterocycl. Compd. , 2014, 50 (4), 514‑527

DOI: 10.1007/s10593-014-1502-7

Petrova O. N.; Zamigajlo L. L.; Gella I. M.; Musatov V. I.; Shishkina S. V.; Shishkin O. V.; Vashchenko E. V.; Borisov A. V.; Lipson V. V.

Generation of C2F5CHN2 In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes

Chem. Eur. J. , 2014, 20 (17), 4942-4947

DOI: 10.1002/chem.201304840

Mykhailiuk P. K.

Synthesis of Thieno[2,3-d]imidazoles by Copper-Catalyzed Amidine Cyclization

Synlett , 2014, 25 (07), 965-968

DOI: 10.1055/s-0033-1340959

Liubchak K.; Tolmachev A.; Nazarenko K.

Enzymatic resolution of chroman-4-ol and its core analogues with Burkholderia cepacia lipase

Tetrahedron: Asymmetry , 2014, 25 (67), 563‑567

DOI: 10.1016/j.tetasy.2014.02.010

Kucher O. V.; Kolodyazhnaya A. O.; Smolii O. B.; Boiko A. I.; Kubyshkin V. S.; Mykhailiuk P. K.; Tolmachev A. A.

Enzyme-Catalyzed Kinetic Resolution of 2,2,2-Trifluoro-1-(heteroaryl)ethanols: Experimental and Docking Studies

Eur. J. Org. Chem. , 2014, 34, 7692-7698

DOI: 10.1002/ejoc.201403013

Kucher O. V.; Kolodiazhnaya A. O.; Smolii O. B.; Prisuazhnyk D. V.; Tolmacheva K. A.; Zaporozhets O. A.; Moroz Y. S.; Mykhailiuk P. K.; Tolmachev A. A.

Role of Protein Phosphatase 1 in Dephosphorylation of Ebola Virus VP30 Protein and Its Targeting for the Inhibition of Viral Transcription

J. Biol. Chem. , 2014, 289 (33), 22723-22738

DOI: 10.1074/jbc.M114.575050

Ilinykh P. A.; Tigabu B.; Ivanov A.; Ammosova T.; Obukhov Y.; Garron T.; Kumari N.; Kovalskyy D.; Platonov M. O.; Naumchik V. S.; Freiberg A. N.; Nekhai S.; Bukreyev A.

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity

Eur. J. Med. Chem. , 2014, 85 245-254

DOI: 10.1016/j.ejmech.2014.07.103

Havrylyuk D.; Zimenkovsky B.; Karpenko O.; Grellier P.; Lesyk R.

Conformational behavior of peptides containing residues of 3-azetidinesulfonic (3AzeS) and 4-piperidinemethanesulfonic (4PiMS) acids

Tetrahedron: Asymmetry , 2014, 25 (3), 229‑237

DOI: 10.1016/j.tetasy.2013.12.001

Grygorenko O. O.; Zhersh S.; Oliinyk B. V.; Shishkin O. V.; Tolmachev A. A.

Synthesis and Functionalization of 3-Azolylquinoxalin-2(1H)-ones

Synthesis , 2014, 46 (11), 1487-1492

DOI: 10.1055/s-0033-1340983

Geraschenko O. V.; Khodakovskiy P. V.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.

Structure Analysis and Conformational Transitions of the Cell Penetrating Peptide Transportan 10 in the Membrane-Bound State

PLoS ONE , 2014, 9 (6), e99653

DOI: 10.1371/journal.pone.0099653

Fanghänel S.; Wadhwani P.; Strandberg E.; Verdurmen W. P. R.; Bürck J.; Ehni S.; Mykhailiuk P. K.; Afonin S.; Gerthsen D.; Komarov I. V.; Brock R.; Ulrich A. S.

Conformationally restricted glutamic acid analogues: stereoisomers of 1-aminospiro[3.3]heptane-1,6-dicarboxylic acid

RSC Adv. , 2014, 4 (21), 10894-10902

DOI: 10.1039/C3RA47725H

Chernykh A. V.; Radchenko D. S.; Grygorenko O. O.; Volochnyuk D. M.; Shishkina S. V.; Shishkin O. V.; Komarov I. V.

One-Pot Parallel Synthesis Approach to Secondary Amines Based on the Reductive Amination of Ketones

Synthesis , 2014, 46 (13), 1765-1772

DOI: 10.1055/s-0033-1341226

Bogolubsky A. V.; Moroz Y. S.; Pipko S. E.; Panov D. M.; Konovets A. I.; Doroschuk R.; Tolmachev A.

Sulfonyl Fluorides as Alternative to Sulfonyl Chlorides in Parallel Synthesis of Aliphatic Sulfonamides

ACS Comb. Sci. , 2014, 16 (4), 192-197

DOI: 10.1021/co400164z

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Pipko S. E.; Konovets A. I.; Sadkova I. V.; Tolmachev A.

A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

ACS Comb. Sci. , 2014, 16 (8), 375-380

DOI: 10.1021/co5000568

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Panov D. M.; Pipko S. E.; Konovets A. I.; Tolmachev A.

Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

ACS Comb. Sci. , 2014, 16 (6), 303-308

DOI: 10.1021/co500025f

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Granat D. S.; Pipko S. E.; Konovets A. I.; Doroschuk R.; Tolmachev A.

Controlling Biological Activity with Light: Diarylethene-Containing Cyclic Peptidomimetics

Angew. Chem. Int. Ed. , 2014, 53 (13), 3392‑3395

DOI: 10.1002/anie.201310019

er S.; Mykhailiuk P. K.; Kubyshkin V. S.; Steinbrecher T.; Ulrich A. S.; Komarov I. V.

Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery

Eur. J. Org. Chem. , 2014, 17, 3592-3598

DOI: 10.1002/ejoc.201402158

Artamonov O. S.; Slobodyanyuk E. Y.; Volochnyuk D. M.; Komarov I. V.; Tolmachev A. A.; Mykhailiuk P. K.

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription

Br. J. Pharmacol. , 2014, 171 (22), 5059-5075

DOI: 10.1111/bph.12863

ren A.; Kovalskyy D.; Nekhai S.

Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines

Eur. J. Org. Chem. , 2013, 15, 3086-3093

DOI: 10.1002/ejoc.201300121

Yarmolchuk V. S.; Shishkin O. V.; Starova V. S.; Zaporozhets O. A.; Kravchuk O.; Zozulya S.; Komarov I. V.; Mykhailiuk P. K.

An approach to dihydroisoindolobenzodiazepinones—three-dimensional molecular frameworks

Tetrahedron Lett. , 2013, 54 (10), 1195-1197

DOI: 10.1016/j.tetlet.2012.12.065

Yaremenko A. G.; Shelyakin V. V.; Volochnyuk D. M.; Rusanov E. B.; Grygorenko O. O.

Newsletter

Get the latest news and updates.

 

Contact Us

8 + 6 =