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Publications

Highly efficient synthesis and NMR features of novel fused pyrimidothiazinium trihalogenides

J. Heterocycl. Chem. 2021, 59 (2), 329-340

DOI: 10.1002/jhet.4387

Onysko M.; Svalyavin O.; Slivka M.; Slivka M.; Baumer V.; Lendel V.

In silico mechanistic model of microtubule assembly inhibition by selective chromone derivatives

J. Mol. Struct. 2021, 1241, 130633

DOI: 10.1016/j.molstruc.2021.130633

Rayevsky A.; Sharifi M.; Samofalova D.; Demchuk O.; Karpov P.; Blume Y.

Bicyclic Pyrrolidines for Medicinal Chemistry via [3 + 2]-Cycloaddition

J. Org. Chem. 2021, 86 (19), 13289–13309

DOI: 10.1002/slct.202001243

Savych V.; Mykhalchuk V.; Melnychuk P.; Isakov A.; Savchuk T.; Timoshenko V.; Siry S.; Pavlenko S.; Kovalenko D.; Hryshchuk O.; Reznik V.; Chalyk B.; Yarmolchuk V.; Rusanov E.

Fluorine-Labelled Spiro[3.3]heptane-Derived Building Blocks: Is Single Fluorine the Best?

Eur. J. Org. Chem. 2021, 2021 (35), 4897-4910

DOI: 10.1002/ejoc.202100804

Malashchuk A.; Chernykh A.; Dobrydnev A.; Grygorenko O.

4-(N-Boc-amino)-1Н-1,2,3-triazolecarbothioamides in the synthesis of a new heterocyclic [1,2,3]triazolo[4,5-e][1,4]thiazepine system

Chem. Heterocycl. Compd. 2021, 57 (7-8), 841-847

DOI: 10.1007/s10593-021-02989-1

Syrota N.; Kemskiy S.; Bol’but A.; Chernobaev I.; Liavinets O.; Vovk M.

Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)

J. Org. Chem. 2021, 86 (17), 12181–12198

DOI: 10.1021/acs.joc.1c01518

Trofymchuk S.; Bugera M.; Klipkov A.; Ahunovych V.; Razhyk B.; Semenov S.; Boretskyi A.; Tarasenko K.; Mykhailiuk P.

Oxa-spirocycles: synthesis, properties and applications

Chem. Sci. 2021, 12 (34), 11294-11305

DOI: 10.1039/d1sc03615g

Fominova K.; Diachuk T.; Granat D.; Savchuk T.; Vilchynskyi V.; Svitlychnyi O.; Meliantsev V.; Kovalchuk I.; Litskan E.; Levterov V. V.; Badlo V. R.; Vaskevych R. I.; Vaskevych A. I.; Bolbut A. V.; Semeno V. V.; Iminov R.; Shvydenko K.; Kuznetsova A. S.; Dmytriv Y. V.; Vysochyn D.; Ripenko V.; Tolmachev A. A.; Pavlova O.; Kuznietsova H.; Pishel I.; Borysko P.; Mykhailiuk P. K.

Strained contacts with the cell membrane may influence ligand affinity to G protein coupled receptors: a case of free fatty acid receptor 1 agonists

J. Enzyme Inhib. Med. Chem. 2021, 36 (1), 1651-1658

DOI: 10.1080/14756366.2021.1955874

Lukin A.; Bakholdina A.; Chudinov M.; Onopchenko O.; Zhuravel E.; Zozulya S.; Gureev M.; Krasavin M.

Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation

Life 2021, 11(7), 659

DOI: 10.3390/life11070659

Rayevsky A.; Sirokha D.; Samofalova D.; Lozhko D.; Gorodna O.; Prokopenko I.; Livshits L.

In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid

Front. Chem. 2021, 9, 688446

DOI: 10.3389/fchem.2021.688446

Afonin S.; Koniev S.; Préau L.; Takamiya M.; Strizhak A.; Babii O.; Hrebonkin A.; Pivovarenko V.; Dathe M.; le Noble F.; Rastegar S.; Strähle U.; Ulrich A.; Komarov I.

Ring-closure reactions of functionalized vinyl sulfonamides

Chem. Heterocycl. Compd. 2021, 57 (6), 630-632

DOI: 10.1007/s10593-021-02960-0

Dodrydnev A.; Omelian T.

Addition reaction of various azoles to perfluoromethyl vinyl ether

Chem. Heterocycl. Compd. 2021, 57 (6), 666-671

DOI: 10.1007/s10593-021-02965-9

Petko K.; Filatov A.

Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL

Chem Sci 2021, 12(28), 9694‑9703

DOI: 10.1039/d1sc01916c

Wong J. Y.; Mukherjee R.; Miao J.; Bilyk O.; Triana V.; Miskolzie M.; Henninot A.; Dwyer J.; Kharchenko S.; Iampolska A.; Volochnyuk D.; Lin Y.; Postovit L.; Derda R.

Quinazoline-containing hydrazydes of dicarboxylic acids and products of their structural modification: A novel class of anti-inflammatory agents

Acta Chim. Slov. 2021, 68 (2), 395-403

DOI: 10.17344/acsi.2020.6440

Krasovska N.; Stavytskyi V.; Nosulenko I.; Karpenko O.; Voskoboinik O.; Kovalenko S.

Third Generation Buchwald Precatalysts with XPhos and RuPhos: Multigram Scale Synthesis, Solvent-Dependent Isomerization of XPhos Pd G3 and Quality Control by 1H- and 31P-NMR Spectroscopy

Molecules 2021, 26(12), 3507

DOI: 10.3390/molecules26123507

Sotnik S.; Mishchenko A.; Rusanov E.; Kozytskiy A.; Gavrilenko K.; Ryabukhin S.; Volochnyuk D.; Kolotilov S.

Cu-Catalyzed Pyridine Synthesis via Oxidative Annulation of Cyclic Ketones with Propargylamine

J. Org. Chem. 2021, 86 (11), 7315-7325

DOI: 10.1021/acs.joc.0c03038

Sotnik S.; Subota A.; Kliuchynskyi A.; Yehorov D.; Lytvynenko A.; Rozhenko A.; Kolotilov S.; Ryabukhin S.; Volochnyuk D.

An alternative approach to the synthesis of [1,2,4]triazolo[1,5-a]pyridine-8-carbonitriles, their crystal structure, and DFT calculations

J. Heterocycl. Chem. 2021, 58 (6), 1278-1285

DOI: 10.1002/jhet.4256

Khomenko D.; Shokol T.; Doroshchuk R.; Starova V.; Raspertova I.; Shova S.; Lampeka R.; Volovenko Y.

Selective α-Methylation of Ketones

J. Org. Chem. 2021, 86 (11), 7333-7346

DOI: 10.1021/acs.joc.1c00148

Frolov A.; Ostapchuk E.; Pashenko A.; Chuchvera Y.; Rusanov E.; Volochnyuk D.; Ryabukhin S.

Modelling of an autonomous Nav1.5 channel system as a part of in silico pharmacology study

J. Mol. Model. 2021, 27 (6), 182

DOI: 10.1007/s00894-021-04799-w

Rayevsky A.; Samofalova D.; Maximyuk O.; Platonov M.; Hurmach V.; Ryabukhin S.; Volochnyuk D.

Efficient synthesis of seven-membered Aza-sultams: Heterofused amino-1,2,4-thiadiazepine dioxides

Tetrahedron 2021, 88, 132149

DOI: 10.1016/j.tet.2021.132149

Hys V.; Milokhov D.; Keda T.; Omelchenko I.; Konovalova I.; Shishkina S.; Volovenko Y.

Evaluation of anticonvulsant activity of dual COX-2/5-LOX inhibitor darbufelon and its novel analogues

Sci. Pharm. 2021, 89(2), 22

DOI: 10.3390/scipharm89020022

Mishchenko M.; Shtrygol’ S.; Lozynskyi A.; Khomyak S.; Novikov V.; Karpenko O.; Holota S.; Lesyk R.

Nature of Fast Relaxation Processes and Spectroscopy of a Membrane-Active Peptide Modified with Fluorescent Amino Acid Exhibiting Excited State Intramolecular Proton Transfer and Efficient Stimulated Emission

ACS Omega 2021, 6 (15), 10119–10128

DOI: 10.1021/acsomega.1c00193

Shaydyuk Y.; Bashmakova N.; Dmytruk A.; Kachkovsky O.; Koniev S.; Strizhak A.; Komarov I.; Belfield K.; Bondar M.; Babii O.

4-(Di-/Trifluoromethyl)-2-heterabicyclo[2.1.1]hexanes: Advanced Fluorinated Phenyl Isosteres and Proline analogues

Eur. J. Org. Chem. 2021, 2021 (47), 6580-6590

DOI: 10.1002/ejoc.202100414

Homon A.; Hryshchuk O.; Mykhailenko O.; Vashchenko B.; Melnykov K.; Michurin O.; Daniliuc C.; Gerus I.; Kovtunenko V.; Kondratov I.; Grygorenko O.

Exploration of the nitrogen heterocyclic periphery around the core of the advanced FFA1 agonist fasiglifam (TAK-875)

Arch. Pharm. 2021, 354 (4), e2000275

DOI: 10.1002/ardp.202000275

Lukin A.; Bakholdina A.; Zhurilo N.; Onopchenko O.; Zhuravel E.; Zozulya S.; Gureev M.; Safrygin A.; Krasavin M.

A Beckmann rearrangement initiated by trifluoromethanesulfonic anhydride in the synthesis of compounds containing a new pyrazolo[3',4':5,6]pyrido[3,2-b]azepine heterocyclic system

Chem. Heterocycl. Compd. 2021, 57 (2), 199-206

DOI: 10.1007/s10593-021-02893-8

Yakovenko G.; Yagodkina-Yakovenko M.; Suykov S.; Vovk M.

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

iScience 2021, 24 (2), 102021

DOI: 10.1016/j.isci.2020.102021

Gorgulla C.; Padmanabha Das K.; Leigh K.; Cespugli M.; Fischer P.; Wang Z.; Tesseyre G.; Pandita S.; Shnapir A.; Calderaio A.; Gechev M.; Rose A.; Lewis N.; et al.

A Diversity-Oriented Approach to Large Libraries of Artificial Macrocycles

Eur. J. Org. Chem. 2021, 2021 (17), 2313-2330

DOI: 10.1002/ejoc.202100195

Kharchenko S.; Iampolska A.; Radchenko D.; Vashchenko B.; Voitenko Z.; Grygorenko O.

Effect of Charge Distribution in a Modified tRNA Substrate on Pre-Reaction Protein-tRNA Complex Geometry

ACS Omega 2021, 6 (6), 4227-4235

DOI: 10.1021/acsomega.0c05143

Rayevsky A.; Sharifi M.; Demianenko E.; Volochnyuk D.; Tukalo M.

Versatile Reactivity of Mn(II) Complexes in Reactions with N-Donor Heterocycles: Metamorphosis of Labile Homometallic Pivalates vs. Assembling of Endurable Heterometallic Acetates

Molecules 2021, 26 (4), 1021

DOI: 10.3390/molecules26041021

Polunin R.; Evstifeev I.; Cador O.; Golhen S.; Gavrilenko K.; Lytvynenko A.; Efimov N.; Minin V.; Bogomyakov A.; Ouahab L.; Kolotilov S.; Kiskin M.; Eremenko I.

Fluorinated Pyrazoles: From Synthesis to Applications

Chem. Rev. 2021, 121 (3), 1670–1715

DOI: 10.1021/acs.chemrev.0c01015

Mykhailiuk P.

Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines

Synthesis 2021, 53 (12), 2133-2141

DOI: 10.1055/a-1360-9852

Mityuk A.; Hrebonkin A.; Lebed P.; Grabchuk G.; Volochnyuk D.; Ryabukhin S.

Bicyclic Piperidines via [2 + 2] Photocycloaddition

J. Org. Chem. 2021, 86 (3), 2200-2209

DOI: 10.1021/acs.joc.0c02355

Shcherbakova V.; Dibchak D.; Snisarenko M.; Skalenko Y.; Denisenko A.; Kuznetsova A.; Mykhailiuk P.

Chemography: Searching for Hidden Treasures

J. Chem. Inf. Model. 2021, 61 (1), 179-188

DOI: 10.1021/acs.jcim.0c00936

Zabolotna Y.; Lin A.; Horvath D.; Marcou G.; Volochnyuk D.; Varnek A.

Synthesis of Furoneoflavones Modified by Coumarin and (HET)Aroyl Substituents

Chem. Nat. Compd. 2021, 57 (1), 33-37

DOI: 10.1007/s10600-021-03275-4

Shokol T.; Moskvina V.; Hlibov Y.; Frasinyuk M.; Khilya V.

Fluoroalkyl-Containing 1,2-Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry

Eur. J. Org. Chem. 2021, 2021 (1), 87-95

DOI: 10.1002/ejoc.202001345

Demchuk O.; Hryshchuk O.; Vashchenko B.; Trofymchuk S.; Melnykov K.; Skreminskiy A.; Volochnyuk D.; Grygorenko O.

Citraconic acid and its anhydride-based hetero-Diels–Alder reactions in the synthesis of new thiopyrano[2,3-d][1,3]thiazole derivatives

Synth. Commun. 2021, 51 (6), 964-970

DOI: 10.1080/00397911.2020.1867868

Zelisko N.; Karpenko O.; Muzychenko V.; Gzella A.; Lesyk R.

Cyclosulfenylation of N-(1(2)-naphthyl) styrylacetamides as a synthetic route to 4(2)-arylthio naphtho[1,2-b]([2,1-b])azepin-2(4)-ones

J. Sulphur Chem. 2021, 42 (3), 264-280

DOI: 10.1080/17415993.2020.1855431

Danyliuk I.; Vaskevych A.; Vaskevych R.; Rusanov E.; Vovk M.

Synthesis of 4-heteryl-substituted derivatives of methylpyrazolo[1,5-a]pyrazine-4-carboxylates

Chem. Heterocycl. Compd. 2020, 56 (12), 1554-1559

DOI: 10.1007/s10593-020-02849-4

Tsizorik N.; Hrynyshyn Y.; Musiychuk A.; Bol’but A.; Nechayev M.; Vovk M.

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

J. Extracell. Vesicles 2020, 10 (2), e12039

DOI: 10.1002/jev2.12039

Leblanc R.; Kashyap R.; Barral K.; Egea-Jimenez A. L.; Kovalskyy D.; Feracci M.; Garcia M.; Derviaux C.; Betzi S.; Ghossoub R.; Platonov M.; Roche P.; Morelli X.; Hoffer L.; Zimmermann P.

Synthesis of α-spirocyclic pyrrolidines

Chem. Heterocycl. Compd. 2020, 56 (11), 1411-1413

DOI: 10.1007/s10593-020-02829-8

Melnykov K.; Ryabukhin S.

[3-(Dimethylamino)-2-(trifluoromethyl)prop-2-en-1-ylidene]dimethylazanium hexafluorophosphate – efficient reagent for the formation of trifluoromethyl-substituted azaheterocycles

Chem. Heterocycl. Compd. 2020, 56 (11), 1408-1410

DOI: 10.1007/s10593-020-02828-9

Mityuk A.; Ryabukhin S.

Modern Approaches to the Creation of Immobilized Metal-Complex Catalysts for Hydrogenation, Alkene Metathesis, and Cross-Coupling Processes: A Review

Theor. Exp. Chem. 2020, 56 (5), 283-308

DOI: 10.1007/s11237-020-09660-4

Ivanytsya M.; Ryabukhin S.; Volochnyuk D.; Kolotilov S.

Enantiomeric N-tert-Butylsulfinyl Imines of Methyl Trifluoropyruvate: Promising Building Blocks in Asymmetric Synthesis of α-Trifluoromethylated Amino Acids and Derivatives

ChemistrySelect 2020, 5 (43), 13569-13574

DOI: 10.1002/slct.202003500

Cherednichenko A.; Bezgubenko L.; Rusanov E.; Onys'ko P.; Rassukana Y.

Efficient synthesis of imidazole and pyrimidine derivatives

Chem. Heterocycl. Compd. 2020, 56 (10), 1329-1334

DOI: 10.1007/s10593-020-02818-x

Kolomoitsev O.; Gladkov E.; Kotlyar V.; Pedan P.; Onipko O.; Buravov O.; Chebanov V.

SAVI, in silico generation of billions of easily synthesizable compounds through expert-system type rules

Scientific Data 2020, 7 (1), 384

DOI: 10.1038/s41597-020-00727-4

Patel H.; Ihlenfeldt W.; Judson P.; Moroz Y.; Pevzner Y.; Peach M.; Delannee V.; Tarasova N.; Nicklaus M.

Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy

Cells 2020, 9 (10), 2272

DOI: 10.3390/cells9102272

Adams V.; Gussen V.; Zozulya S.; Cruz A.; Moriscot A.; Linke A.; Labeit S.

Composites Based on Nanodispersed Nickel, Graphene-Like Carbon, and Aerosil for Catalytic Hydrogenation of Furfural and Quinoline

Theor. Exp. Chem. 2020, 56 (4), 261-267

DOI: 110.1007/s11237-020-09657-z

Asaula V.; Shvets O.; Pariiska O.; Bur’yanov V.; Ryabukhin S.; Volochnyuk D.; Kolotilov S.

Formyl MIDA Boronate: C1 Building Block Enables Straightforward Access to α-Functionalized Organoboron Derivatives

Angew. Chem. Int. Ed. 2020, 59 (41), 18016‑18022

DOI: 10.1002/anie.202007651

Ivon Y.; Mazurenko I.; Kuchkovska Y.; Voitenko Z.; Grygorenko O.

Fluoroalkyl-Substituted Cyclopropane Derivatives: Synthesis and Physicochemical Properties

J. Org. Chem. 2020, 85 (19), 12692-12702

DOI: 10.1021/acs.joc.0c01848

Chernykh A.; Olifir O.; Kuchkovska Y.; Volochnyuk D.; Yarmolchuk V.; Grygorenko O.

An efficient method for accessing carboannulated and functionalized [1,2,3]triazolo[4,5-b]pyridines

Chem. Heterocycl. Compd. 2020, 56 (8), 1048‑1053

DOI: 10.1007/s10593-020-02771-9

Syrota N.; Kemskiy S.; Bol’but A.; Chernobaev I.; Vovk M.
 

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