Publications

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

Nature 2020, 579 (7800), 609-614

DOI: 10.1038/s41586-020-2027-0

Stein R.; Kang H.; McCorvy J.; Glatfelter G.; Jones A.; Che T.; Slocum S.; Huang X.; Savych O.; Moroz Y.; Stauch B.; Johansson L.; Cherezov V.; Kenakin T.; Irwin J.; Shoichet B.; Roth B.; Dubocovich M.
Aliphatic α‐Boryl‐α‐bromoketones: Synthesis and Reactivity

Eur. J. Org. Chem. 2020, 2020 (23), 3367-3377

DOI: 10.1002/ejoc.202000078

Ivon Y.; Kuchkovska Y.; Voitenko Z.; Grygorenko O.
Cyclopropylation of heterocyclic cores using cyclopropylboronic derivatives

Chem. Heterocycl. Compd. 2020, 56 (1), 39-41

DOI: 10.1007/s10593-020-02619-2

Grygorenko O.; Hryshchuk O.
Semi-Industrial Fluorination of β-Keto Esters with SF4: Safety vs Efficacy

Synlett 2020, 31 (06), 565-574

DOI: 10.1055/s-0037-1610744

Trofymchuk S.; Kliukovskyi D.; Semenov S.; Khairulin A.; Shevchenko V.; Bugera M.; Tarasenko K.; Volochnyuk D.; Ryabukhin S.
Deoxofluorination of (Hetero)aromatic Acids

J. Org. Chem. 2020, 85 (5), 3110-3124

DOI: 10.1021/acs.joc.9b03011

Trofymchuk S.; Bugera M.; Klipkov A.; Razhyk B.; Semenov S.; Tarasenko K.; Starova V.; Zaporozhets O.; Tananaiko O.; Alekseenko A.; Pustovit Y.; Kiriakov O.; Gerus I.; Tolmachev A.; Mykhailiuk P.
The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

Chem. Eur. J. 2020, 26 (6), 1196-1237

DOI: 10.1002/chem.201903232

Grygorenko O.; Volochnyuk D.; Ryabukhin S.; Judd D.
Synthesis and chemical transformations of diazolyl α,α-difluoroacetates

J. Fluorine Chem. 2020, 229

DOI: 10.1016/j.jfluchem.2019.109407

Geraschenko O.; Solomin V.; Vashchenko B.; Khodakivskyi P.; Tolmachev A.; Grygorenko O.
Diazoacetonitrile (N2CHCN): A Long Forgotten but Valuable Reagent for Organic Synthesis

Chem. Eur. J. 2020, 26 (1), 89-101

DOI: 10.1002/chem.201903335

Mykhailiuk P.; Koenigs R.
Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

J. Enzyme Inhib. Med. Chem. 2020, 35 (1), 306‑310

DOI: 10.1080/14756366.2019.1698562

Krasavin M.; Kalinin S.; Zozulya S.; Gryniukova A.; Borysko P.; Angeli A.; Supuran C.
Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

J. Enzyme Inhib. Med. Chem. 2020, 35 (1), 165‑171

DOI: 10.1080/14756366.2019.1693556

Krasavin M.; Kalinin S.; Zozulya S.; Griniukova A.; Borysko P.; Angeli A.; Supuran C.
Synthesis of naphtho[1,2-b]-, naphtho[2,1-b]-, and naphtho[2,3-b]azepinones via proton-induced cyclization of N-1(2)-naphthyl styrylacetamides

J. Heterocycl. Chem. 2020, 57 (1), 317-326

DOI: 10.1002/jhet.3779

Danyliuk I.; Vaskevych R.; Vaskevych A.; Suikov S.; Rusanov E.; Chornous V.; Vovk M.
Building the Housane: Diastereoselective Synthesis and Characterization of Bicyclo[2.1.0]pentane Carboxylic Acids

J. Org. Chem. 2020, 85 (4), 2321-2337

DOI: 10.1021/acs.joc.9b03044

Semeno V.; Vasylchenko V.; Vashchenko B.; Lutsenko D.; Iminov R.; Volovenko O.; Grygorenko O.
A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Sci. Rep. 2019, 9 (1), 19585

DOI: 10.1038/s41598-019-55069-y

Chiba S.; Ohue M.; Gryniukova A.; Borysko P.; Zozulya S.; Yasuo N.; Yoshino R.; et al.
Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes

J. Org. Chem. 2019, 84 (24), 15877-15899

DOI: 10.1021/acs.joc.9b02264

Chalyk B.; Hrebeniuk K.; Fil Y.; Gavrilenko K.; Rozhenko A.; Vashchenko B.; Borysov O.; Biitseva A.; Lebed P.; Bakanovych I.; Moroz Y.; Grygorenko O.
Supreme activity of gramicidin S against resistant, persistent and biofilm cells of staphylococci and enterococci

Sci. Rep. 2019, 9 (1), 17938

DOI: 10.1038/s41598-019-54212-z

Berditsch M.; Afonin S.; Reuster J.; Lux H.; Schkolin K.; Babii O.; Radchenko D. S.; Abdullah I.; William N.; Middel V.; Strahle U.; Nelson A.; Valko K.; Ulrich A.
Synthesis of azachromones and azachromanones

Chem. Heterocycl. Compd. 2019, 55 (11), 1007–1012

DOI: 10.1007/s10593-019-02570-x

Malets Y.; Moskvina V.; Grygorenko O.; Brovarets V.
Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki–Miyaura cross coupling

Chem. Heterocycl. Compd. 2019, 55 (11), 1070-1074

DOI: 10.1007/s10593-019-02579-2

Hrynyshyn Y.; Musiychuk A.; Tsizorik N.; Bol’but A.; Vovk M.
4-(Boc-amino)-1Н-1,2,3-triazole-5-carboxylic acids –convenient reagents for the synthesis of 1,4,6,7-tetrahydro[1,2,3]- triazolo[4,5-е][1,4]diazepine-5,8-diones

Chem. Heterocycl. Compd. 2019, 55 (11), 1092‑1097

DOI: 10.1007/s10593-019-02583-6

Syrota N.; Kemskiy S.; Bol’but A.; Vovk M.
Synthesis of fluorinated dipyrazolyl sulfones from bis(2-fluoro-2-polyfluoroalkylalkenyl) sulfones and diazomethane

Chem. Heterocycl. Compd. 2019, 55 (11), 1065-1069

DOI: 10.1007/s10593-019-02578-3

Borodkin Y.; Rusanov E.; Khizhan A.; Shermolovich Y.
Far Away from Flatland. Synthesis and Molecular Structure of Dihetera[3.3.n]propellanes and Trihetera[3.3.n]propellanes: Advanced Analogues of Morpholine/Piperazine

J. Org. Chem. 2019, 84 (21), 13908-13921

DOI: 10.1021/acs.joc.9b02067

Sokolenko Y.; Yurov Y.; Vashchenko B.; Hryshchuk O.; Filimonova Y.; Ostapchuk E.; Artemenko A.; Zaremba O.; Grygorenko O.
Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles

J. Org. Chem. 2019, 84 (23), 15212-15225

DOI: 10.1021/acs.joc.9b02258

Chalyk B.; Khutorianskyi A.; Lysenko A.; Fil Y.; Kuchkovska Y.; Gavrilenko K.; Bakanovych I.; Moroz Y.; Gorlova A.; Grygorenko O.
Synthesis of pyrazolo[1,5-a]pyrazin-4-ylacetonitriles and their annulation with pyridine ring

Chem. Heterocycl. Compd. 2019, 55 (9), 893‑896

DOI: 10.1007/s10593-019-02554-x

Tsizorik N.; Hrynyshyn Y.; Musiychuk A.; Bol’but A.; Vovk M.
Hetaryl-substituted bicyclo[1.1.1]pentanes

Chem. Heterocycl. Compd. 2019, 55 (10), 933‑935

DOI: 10.1007/s10593-019-02558-7

Grygorenko O.; Kokhan S.
Multigram Synthesis and C−C/C−N Couplings of Functionalized 1,2‐Disubstituted Cyclopropyltrifluoroborates

Adv. Synth. Catal. 2019, 361 (23), 5428-5439

DOI: 10.1002/adsc.201900879

Hryshchuk O.; Yurov Y.; Tymtsunik A.; Kovtunenko V.; Komarov I.; Grygorenko O.
Convenient Access to Conformationally Rigid Sultams

Org. Lett. 2019, 21 (22), 8909-8914

DOI: 10.1021/acs.orglett.9b03080

Dibchak D.; Shcherbacova V.; Denisenko A.; Mykhailiuk P.
Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization

J. Org. Chem. 2019, 84 (23), 15106-15117

DOI: 10.1021/acs.joc.9b01947

Bychek R.; Hutskalova V.; Bas J.; Zaporozhets O.; Zozulia S.; Levterov V.; Mykhailiuk P.
Cascade reactions for constructing heterocycles containing a pyrimidino-pyrazino-pyrimidine core using 1,2,4-triazole scaffolds

Tetrahedron Lett. 2019, 60 (39), 151089 - 4

DOI: 10.1016/j.tetlet.2019.151089

Khomenko D.; Doroshchuk R.; Raspertova I.; García López J.; López Ortiz F.; Shova S.; Iegorov O.; Lampeka R.
Hindered dialkyl ether synthesis with electrogenerated carbocations

Nature 2019, 573 (7774), 398-402

DOI: 10.1038/s41586-019-1539-y

Xiang J.; Shang M.; Kawamata Y.; Lundberg H.; Reisberg S.; Chen M.; Mykhailiuk P.; Beutner G.; Collins M.; Davies A.; Del Bel M.; Gallego G.; Spangler J.; Starr J.; Yang S.; Blackmond D.; Baran P.
SAR by space: Enriching hit sets from the chemical space

Molecules 2019, 24 (17), 3096

DOI: 10.3390/molecules24173096

Klingler F.; Gastreich M.; Grygorenko O.; Savych O.; Borysko P.; Griniukova A.; Gubina K.; Lemmen C.; Moroz Y.
Saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties

Chem. Heterocycl. Compd. 2019, 55 (8), 692‑694

DOI: 10.1007/s10593-019-02521-6

Grygorenko O.; Melnykov K.
Piperidines decorated by small (cyclo)alkyl substituents

Chem. Heterocycl. Compd. 2019, 55 (7), 601-603

DOI: 10.1007/s10593-019-02503-8

Subota A.; Volochnyuk D.
Robust and Scalable Approach to 1,3-Disubstituted Pyridylcyclobutanes

Eur. J. Org. Chem. 2019, (34), 5937-5949

DOI: 10.1002/ejoc.201901001

Demchuk O.; Hryshchuk O.; Vashchenko B.; Radchenko D.; Kovtunenko V.; Komarov I.; Grygorenko O.
Formation of 10/12/14‐Membered Rings is Favored over 5/6/7‐Membered. An Unexpected Result from Oxazole Chemistry

Eur. J. Org. Chem. 2019, (30), 4962-4967

DOI: 10.1002/ejoc.201900914

Slobodyanyuk E.; Berezowska Y.; Solomin V.; Volochnyuk D.; Rozhenko A.; Ryabukhin S.; Grygorenko O.
The Boron‐Wittig Olefination of Aldehydes and Ketones with Bis[(pinacolato)boryl]methane: an Extended Reaction Scope

Eur. J. Org. Chem. 2019, (33), 5624-5635

DOI: 10.1002/ejoc.201900648

Kovalenko M.; Yarmoliuk D.; Serhiichuk D.; Chernenko D.; Smyrnov V.; Breslavskyi A.; Hryshchuk O.; Kleban I.; Rassukana Y.; Tymtsunik A.; Tolmachev A.; Kuchkovska Y.; Grygorenko O.
Synthesis and cytotoxicity of new 2-oxo-7-phenyl-2,3-dihydrothiazolo[4,5-b]pyridine-5-carboxylic acid amides

Phosphorus, Sulfur, Silicon Relat. Elem. 2019, 194 (12), 1149-1157

DOI: 10.1080/10426507.2019.1633318

Lozynskyi A.; Zimenkovsky B.; Ivasechko I.; Senkiv J.; Gzella A.; Karpenko O.; Stoika R.; Lesyk R.
CoII Complexes with a Tripyridine Ligand, Containing a 2,6-Di-tertbutylphenolic Fragment: Synthesis, Structure, and Formation of Stable Radicals

ACS Omega 2019, 4 (1), 203-213

DOI: 10.1021/acsomega.8b02595

Dorofeeva V.; Pavlishchuk A.; Kiskin M.; Efimov N.; Minin V.; Lytvynenko A.; Gavrilenko K.; Kolotilov S.; Novotortsev V.; Eremenko I.
3-Functional substituted 4-trifluoromethyl tetrahydrothiophenes via [3 + 2]-cycloaddition reactions

J. Sulfur Chem. 2019, 40 (6), 629-640

DOI: 10.1080/17415993.2019.1633326

Markitanov Y.; Timoshenko V.; Rudenko T.; Rusanov E.; Shermolovich Y.
Reaction of β-alkoxyvinyl α-ketoesters with acyclic NCN binucleophiles – scalable approach to novel functionalized pyrimidines

Tetrahedron 2019, 75 (25), 3472-3478

DOI: 10.1016/j.tet.2019.05.005

Stepaniuk O.; Rudenko T.; Vashchenko B.; Matvienko V.; Kondratov I.; Tolmachev A.; Grygorenko O.
Synthesis of 2,2-disubstituted spirocyclic pyrrolidines by intramolecular Dieckmann condensation

Eur. J. Org. Chem. 2019, (22), 3553-3559

DOI: 10.1002/ejoc.201801750

Fominova K.; Diachuk T.; Sadkova I.; Mykhailiuk P.
Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents

Eur. J. Med. Chem. 2019, 174, 292-308

DOI: 10.1016/j.ejmech.2019.04.052

Kryshchyshyn A.; Kaminskyy D.; Karpenko O.; Gzella A.; Grellier P.; Lesyk R.
N-Difluoromethylation of monosubstituted polydentate azoles

Chem. Heterocycl. Compd. 2019, 55 (4-5), 359-366

DOI: 10.1007/s10593-019-02465-x

Petko K.; Sokolenko T.; Filatov A.; Polovinko V.; Rusanov E.; Dudko V.; Yagupolskii Y.
A new method for the construction of [1,2,4]triazolo[1,5-a]pyridine system

Chem. Heterocycl. Compd. 2019, 55 (4-5), 367-373

DOI: 10.1007/s10593-019-02466-w

Kovtunenko V.; Potikha L.; Shelepyuk A.; Tarasiuk T.
Cationic ring contraction of seven-membered cycle of 3,4-dihydro-2H-1,5-benzoxathiepine derivatives

Chem. Heterocycl. Compd. 2019, 55 (4-5), 416-420

DOI: 10.1007/s10593-019-02474-w

Tarasiuk T.; Shyshkina O.; Potikha L.; Volovenko Y.
Expanding the chemical space of sp3-enriched 4,5-disubstituted oxazoles via synthesis of novel building blocks

Chem. Heterocycl. Compd. 2019, 55 (4-5), 421-434

DOI: 10.1007/s10593-019-02475-9

Slobodyanyuk E.; Andriienko A.; Vashchenko B.; Volochnyuk D.; Ryabukhin S.; Grygorenko O.
N-Boc-4-aminopyrazole-5-carbaldehydes in Friendländer synthesis of pyrazolo[4,3-b]pyridines

Chem. Heterocycl. Compd. 2019, 55 (4-5), 379-385

DOI: 10.1007/s10593-019-02468-8

Yakovenko G.; Lukianov O.; Bol’but A.; Vovk M.
An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups

J. Fluorine Chem. 2019, 224, 61-66

DOI: 10.1016/j.jfluchem.2019.05.006

Subota A.; Ryabukhin S.; Gorlova A.; Grygorenko O.; Volochnyuk D.
Multigram Synthesis of Functionalized Spirocyclic Diazirines

Eur. J. Org. Chem. 2019, (23), 3744-3750

DOI: 10.1002/ejoc.201900485

Martyloga O.; Myronenko A.; Tkachenko A.; Matvienko V.; Kuchkovska Y.; Grygorenko O.
Scalable and Straightforward Synthesis of All Isomeric (Cyclo)alkylpiperidines

Eur. J. Org. Chem. 2019 (22), 3636-3648

DOI: 10.1002/ejoc.201900450

Subota A.; Lutsenko A.; Vashchenko B.; Volochnyuk D.; Levchenko V.; Dmytriv Y.; Rusanov E.; Gorlova A.; Ryabukhin S.; Grygorenko O.
Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds

Beilstein J. Org. Chem. 2019, 15, 1032-1045

DOI: 10.3762/bjoc.15.101

Lipson V.; Pavlovska T.; Svetlichnaya N.; Poryvai A.; Gorobets N.; Van Der Eycken E.; Konovalova I.; Shiskina S.; Borisov A.; Musatov V.; Mazepa A.
Synthesis of Novel 3 a-Substituted Tetrahydro-1H-1λ6 -pyrrolo[1,2-b]isothiazole-1,1,3(2H)-triones through the CSIC Reaction

ChemistrySelect 2019, 4 (17), 4933-4937

DOI: 10.1002/slct.201900650

Omelian T.; Dobrydnev A.; Ostapchuk E.; Volovenko Y. M.

FOLLOW US