Boronic acids, organoboronates and other related compounds have gained popularity in medicinal chemistry recently. Organoboron derivatives are commonly used reagents for C–C bond formation, either via classical palladium-mediated transformations or through other more recent coupling methods. Enamine offers over 2 000 organoboron derivatives from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel organoboron derivatives that we design and synthesize in our labs.
Boronic acids and their derivatives
Novel organoboron derivatives
Every month we synthesize dozens of new organoboron derivatives that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Building blocks for parallel synthesis
Organoboron derivatives have found a wide application in synthesis of compound libraries first of all because of smoothly running Suzuki–Miyaura C–C coupling reactions. Using our in-house developed reactivity filters we have selected a range of organoboron derivatives that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of organoboron derivatives can be easily shared on your request.
Screening compounds and fragments
Screening compounds and fragments containing boron are of particular interest to drug discovery as covalent modifiers selectively acting at serine residues in the active site of the biological target. We offer special selections of organoboron derivatives from Enamine’s fragment collection.
Organotrifluoroborates and MIDA boronates
Since boronic acids in some cases have limited self-stability, several synthetic equivalents are available for them. Being in line with this trend, we have prepared a subset of MIDA boronates and trifluoroborates for your research.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Aryl halides are one of the most popular classes of functional compounds in medicinal chemistry. They have always been drawing synthetic chemists’ attention as beneficial reagents for arylation or for further aromatic core modification. Enamine offers over 21 000 aryl halides from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel aryl halides that we design and synthesize in our labs.
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Aryl halides
Item
Fluorinated
Five-membered rings
Six-membered rings
Bicyclic
Item
Bifunctional
Five-membered rings
Six-membered rings
Bicyclic
Novel aryl halides
Every month we synthesize nearly a hundred new aryl halides that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Scaffolds
Our aryl halides-based scaffolds are represented by a considerable number of building blocks with at least two variation points allowing selective chemical modification.
Building blocks for parallel synthesis
Aryl halides have found a wide application in synthesis of compound libraries first of all because of smoothly running arylation reactions, as well as palladium-catalyzed couplings. Using our in-house developed reactivity filters we have selected a range of aryl halides that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of aryl halides can be easily shared on your request.
Building blocks and scaffolds for DNA-Encoded Library (DEL) synthesis
Design of the scaffolds for synthesis of DEL libraries should respect principle of orthogonal reactivity of the functional groups coupled with their relatively high reactivity allowing for smooth and selective reactions under mild reaction conditions. Only the right combination of functional groups allows using the compound in DEL synthesis. Enamine offers numerous DNA-compatible aryl halides with additional functional groups such as carboxylic, amino groups, aldehydes, etc.
MADE aryl halides
Having synthesized thousands of aryl halides and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalog. We have gathered our ideas of such new building blocks in a database that can be shared on request.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Alkyl halides are one of the most popular classes of functional compounds in medicinal chemistry. They are classical electrophilic reagents for the formation of C–N, C–O, C–S and C–C bonds through the corresponding alkylation reactions. Enamine offers over 10 000 alkyl halides from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel alkyl halides that we design and synthesize in our labs.
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Alkyl halides
Novel alkyl halides
Every month we synthesize nearly a hundred new alkyl halides that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Building blocks for parallel synthesis
Alkyl halides have found a wide application in synthesis of compound libraries first of all because of smoothly running in various alkylation reactions. Using our in-house developed reactivity filters we have selected a range of alkyl halides that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of alkyl halides can be easily shared on your request.
MADE alkyl halides
Having synthesized thousands of alkyl halides and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalog. We have gathered our ideas of such new building blocks in a database that can be shared on request.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Aldehydes are one of the most popular classes of functional compounds in medicinal chemistry. They are relatively stable in air but at the same time reactive enough in various reactions such as reductive amination and addition of organometallics leading to formation of both C–N and C–C bonds. Enamine offers over 5 000 aldehydes from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel aldehydes that we design and synthesize in our labs.
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Aldehydes
Novel aldehydes
Every month we synthesize nearly a hundred new aldehydes that we immediately commercialize in our catalog available for browsing at EnamineStore. It is also accessible with a minimum delay in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.
Building blocks for parallel synthesis
Aldehydes have found a wide application in synthesis of compound libraries first of all because of smoothly running reductive amination. Using our in-house developed reactivity filters we have selected a range of aldehydes that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of aldehydes can be easily shared on your request.
Building blocks and scaffolds for DNA-Encoded Library (DEL) synthesis
Design of the scafoldfs for synthesis of DEL libraries should respect principle of orthogonal reactivity of the functional groups coupled with their relatively high reactivity allowing for smooth and selective reactions under mild reaction conditions. Only the right combination of functional groups allows using the compound in DEL synthesis. Enamine offers numerous DNA-compatible aldehydes with additional functional groups such as carboxylic, amino groups, halogens, etc.
MADE aldehydes
Having synthesized thousands of aldehydes and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalog. We have gathered our ideas of such new building blocks in a database that can be shared on request.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Enamine designs, develops and synthesizes chemical reagents, scaffolds and intermediates widely known as building blocks. They are convenient for using in medicinal chemistry and synthesis of combinatorial compound libraries.
Our catalogue currently contains 1 345 000 building blocks including 300 000 compounds in stock, which can be delivered within 1-7 days from our global logistics centers in the USA and Europe, and via our official distributors in Asia and Oceania. To date, Enamine collection is the largest and most abundant single source of medchem building blocks in the world
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Key Facts:
- Most building blocks are available from stock in 1-5 g amounts.
- At EnamineStore.com you can find up-to-date prices, availability, and lead times for most of the building blocks in stock and for synthesis.
- All of our chemical building blocks undergo extensive quality control by NMR and LC-MS, and purity is guaranteed to be over 95%.
- You can download MSDS and CoA for most of the building blocks here.
Below is a diagram showing stock composition by classes of building blocks:
You can browse and purchase our building blocks at our online shop EnamineStore. There you will get up-to-date price, availability, and lead time information.
Each month our catalogue is enriched with over 1 500 new building blocks. You can be among the first to discover these innovative molecules by subscribing to our Catalogue Update Letters. Each of these monthly updates will bring you around 60 carefully selected, most interesting structures of building blocks that are available for immediate purchase from our stock.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Support
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.
