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Aldehydes

Aldehydes are one of the most popular classes of functional compounds in medicinal chemistry. They are relatively stable in air but at the same time reactive enough in various reactions such as reductive amination and addition of organometallics leading to formation of both C–N and C–C bonds. Enamine offers over 5 000 aldehydes from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel aldehydes that we design and synthesize in our labs.

Aldehydes

 
Aliphatic
Aromatic
Small rings

Item

Original

Aliphatic


EN300-91418

Aromatic


EN300-103208

Small rings


EN300-396135

Item

Fluorinated

Aliphatic


EN300-175987

Aromatic


EN300-219318

Small rings


EN300-157825

Item

Bifunctional

Aliphatic


EN300-156699

Aromatic


EN300-60212

Small rings


EN300-71371

Novel aldehydes

Every month we synthesize nearly a hundred new aldehydes that we immediately commercialize in our catalogue available for browsing at EnamineStore. It is also accessible with a minimum delay in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.

Building blocks for parallel synthesis

Aldehydes have found a wide application in synthesis of compound libraries first of all because of smoothly running reductive amination. Using our in-house developed reactivity filters we have selected a range of aldehydes that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of aldehydes can be easily shared on your request.


Building blocks and scaffolds for DNA-Encoded Library (DEL) synthesis

Design of the scafoldfs for synthesis of DEL libraries should respect principle of orthogonal reactivity of the functional groups coupled with their relatively high reactivity allowing for smooth and selective reactions under mild reaction conditions. Only the right combination of functional groups allows using the compound in DEL synthesis. Enamine offers numerous DNA-compatible aldehydes with additional functional groups such as carboxylic, amino groups, halogens, etc.

Special subsets

Heterocyclic aldehydes

Functionalized aldehydes & linkers

REAL aldehydes

Having synthesized thousands of aldehydes and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalogue. We have gathered our ideas of such new building blocks in a database that can be shared on request.

Services

Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.

Library Synthesis

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