Meet our delegates at International Symposium on DEL in Zurich to learn on our approaches in selecting DEL-compatible building blocks and on our advances in intriguing designs of novel chemotypes >>>
News
In a recent JACS paper several academic groups collaborated on discovery of novel covalent inhibitors using a library of 993 acrylamides and chloroacetamides sourced from Enamine’s covalent fragment collection. The design was focusing on mild electrophiles that were supposed to overcome the selectivity challenge. The library was characterized by a new high-throughput thiol-reactivity assay and screened against 10 cysteine-containing proteins. Potent and unique primary hits have been found in the majority (7 out of 10) of cases.
EU-funded project PELICO, under Enamine’s coordination, reports promising results in synthesis of peptides, their pharmacokinetic and toxicity studies, and coupling with photo-controlled building blocks to yield new photo-controlled peptidomimetics.
Enamine's chemists and biologists from Bienta just published an article in ACS Comb. Sci. describing design and synthesis of a new sulfonyl-fluoride-based covalent fragment library. The library was validated by screening against a model protease, trypsin, and some fragment hits were identified. See ACS website for more details.
680 million new compounds: REAL Database doubled its size in the new release and offers 20% off for the selections of analogues made online at EnamineStore.com.
Recent publication by our chemists describes gram-scale synthesis and some chemical transformations of novel trifunctional C2 building blocks – MIDA boronate shown below.
Enamine is organizing a research workshop within a framework of the company’s participation in a HORIZON-2020 project. The workshop will be held on June 17-19, 2017 in a hotel “Rus” under the supervision of Prof. I.V.Komarov.
EnamineStore expands its e-commerce functionality: online access to safety and analytical data on purchased compounds; requesting analogues; getting online quotes; automated order processing and more arrivals Read more...
Dr. Pavel MYKHAILIUK, CSO at Enamine, has become a finalist at European Young Chemist Award 2016. He gave a talk at 6th EuCheMS Chemistry Congress (Seville, Spain, September 11-15). The European Young Chemist Award 2016 is intended to showcase and recognise the excellent research being carried out by young scientists working in the chemical sciences.
Enamine announces the launch of a mobile version of EnamineStore catalog of building blocks and screening compounds. Realizing the growing number of mobile internet users among our customers, we have developed EnamineStore MobileBeta which is optimized for smartphones and tablet PCs. We hope it will further improve catalog browsing and shopping experience for our customers and stimulate the use of new mobile technologies to access our website.
Please, read more at our blog and explore EnamineStore Mobile for yourself.
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In continuation of our efforts to make affordable screening libraries that can quickly be supplied for screening, we have plated two new targeted libraries designed to bring high quality and novelty to your hit finding program. Both freshly-made libraries are ready for fast shipment within only one week in various formats including assay-ready plates.
Ion Channel Library contains 36 800 compounds.
Protein-Protein Interaction Library has 40 640 compounds including 8 960 Protein Mimetics.
Scientists at the UCSF, together with colleagues at the UNC, created the largest “docking-friendly” database of molecules, based on the Readily Accessible (REAL) compounds from Enamine. Practical validation of the new database was recently published in Nature magazine, demonstrating that it is capable of identifying extremely powerful and synthetically available new hits.
The demand for library synthesis at Enamine driven by the on-site access to the world’s largest and most reputable stock of building block has multiplied in 2018. We keep developing our preparative chromatography capabilities to sustain the drastically increasing number of compounds produced.
Our compound management team at Enamine is excited about the recent acquisition of the Echo® 550 Liquid Handler from Labcyte. This robotic superhero is expected to significantly speed up and notably precise compound handling, which is exactly an option needed for 2.5 Million+ compounds in stock. Screening libraries at Enamine are now more accessible, more customized and assay-ready to meet your exact needs in compound screening.
Accessing new chemistry for drug discovery has been recently facilitated by the approach developed by John Irwin et al. (DOI: 10.1021/acs.jcim.7b00316). Combination of Similarity Ensemble Approach (SEA) with the maximum Tanimoto similarity to the nearest bioactive was found to provide efficient prediction for all 400 million commercially available compounds in ZINC database including 340 million Enamine’s REAL compounds. You can access the files at https://zinc15.docking.org and http://files.docking.org/catalogs/20/enamine-v/. REAL compounds will be synthesized at Enamine on your request in less than 3 weeks with over 85% success rate!
Reactions conducted in autoclaves are very popular at Enamine because they allow synthesis of unique and novel building blocks that would not be doable otherwise. The key to their successful implementation into every day’s routine are quality pressure reactors that offer safe operations and are inexpensive at the same time.
Enamine is proud to announce that it has expanded its building blocks storage facility in Cincinnati totaling now 72 000 compounds. This allows Enamine to expedite logistics with its numerous US customers, offering a next-day delivery option for the majority of orders.
Enamine is announcing the expansion of its building blocks storage in its Cincinnati, logistic center, reaching currently more than 50 000 novel substances, with the plan to reach through its continued efforts at least 60 000 building blocks until the end of 2016. The company fulfills in this way the request of its numerous USA customers to expedite delivery time and fasten projects start.
This year Enamine celebrates 25 years of excellence in chemistry. In commemoration of this special event, we have launched a total discount program at EnamineStore.com. Please visit our online shop and apply for exceptional 25% discount for 160 000+ building blocks, 2 100 000+ screening compounds and 50 000+ fragments in stock.
Upon confirmation, your profile at EnamineStore will be granted with 25% discount that will be further automatically applied to all your online purchases made until October 31, 2016.
Hurry up! The program has just started today and the clock is ticking for this exclusive offer!
Announced on 1st March, 2016 ChemSpace, a global e-procurement marketplace for searching, purchasing and selling chemical building blocks, has already accumulated over 20 million unique reagents and become the world’s largest pool of purchasable building blocks for medicinal chemistry. ChemSpace’s powerful engine supports storage and operations with millions of chemical entries. The platform sets no limits for suppliers and thus provides access to the most actual information on innovative molecules that have just appeared on the market.