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Lipid GPCR Library

A sub-library of Enamine’s GPCR Library designed for discovery of novel lipid GPCR ligands

5 632 compounds

Enamine’s Lipid GPCR Library has been designed in collaboration with NQuiX. Over 5 632 compounds have been selected from off-the-shelf collection or specifically synthesized for this project from Enamine REAL screening Collection. They were designed to target the family of eight endothelial differentiation gene (EDG) receptors (S1P1–5 and LPA1–3). The compounds may also be appropriate for screening at GPR3, GPR6 and GPR12 orphan receptors given some TM bundle binding site similarity and/or GPR23, GPR92 and P2Y5 given their more recent classification as additional, albeit distinct, LPA receptors.

Most popular library formats

Catalog No.
Compounds
Plates
Amount
Format
Price

Catalog No.

LGR-5-Y-0

Compounds

5 632

Plates

157

Amount

Any suitable for 1 assay

Format

384-well microplates, 320 compounds per plate, first two and last two columns empty

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Catalog No.

LGR-5-Z-10

Compounds

5 632

Plates

40

Amount

10 µL of 10 mM DMSO stock solutions

Format

1536-well microplates, Echo Qualified, 1280 compounds per plate, first four and last four columns empty

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Request a quote

Catalog No.

LGR-5-Y-50

Compounds

5 632

Plates

157

Amount

50 µL of 10 mM DMSO solutions

Format

384-well microplates, 320 compounds per plate, first two and last two columns empty

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Request a quote

Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

Library Design

The compounds have been selected using a combination of ligand-based methods using chemical fingerprints, 2D pharmacophores and 3D shape/feature matches (Figure 1). The training active compound set included 1 393 compounds (870 acidic and 523 non-acidic), collected across 73 papers (Figure 2). They represent a combination of compounds for expanding SAR around known chemotypes and scaffold hops seeking novelty. The current set of compounds covers the non-acidic classes of ligand, with acidic compounds being designed via a different procedure and added to the library separately.

Fig. 1.Dedicated design of the compounds included in the Library (general scheme).

Fig. 2. Distribution of the compounds in the training set.

Examples of the molecules

GPCR Library

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