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Discovery Diversity Set

Top-quality diverse library of recently synthesized compounds

50 240 compounds

The success of high throughput screening in finding decent starting points for drug discovery heavily depends on the quality of the compound library. Compound screening libraries nowadays must bear an essential degree of novelty, possess contemporary lead-like properties and be built on “live” chemistry that can supply related chemical entities.

Only within last three years Enamine synthesized over 450 000 screening compounds for its public catalogue. These substances feature a new structural diversity of Enamine unique building blocks and scaffolds. Having the largest commercial screening collection in the world, Enamine remains the only library producer that keeps enhancing its collection with significant number of new compounds each year. The renowned quality of compounds has been distilled in the design of two Discovery Diversity Sets (DDS). Discovery Diversity Sets are based only on the lead-like compounds including representatives of all three screening collections of Enamine – HTS, Advanced, and Premium.

The Discovery Diversity Sets are highly recommended for random screening against both new and well-investigated protein targets because of high scaffold diversity and presence of the latest Enamine’s building blocks.

Most popular library formats available for immediate supply

Item
Catalog ID
Compounds
Plates
Amount
Formats

Item

1

Catalog ID

DDS-50-Z-0

Compounds

50 240

Plates

40

Amount

Any suitable for 1 assay

Plates and format

1536-well microplates, Echo Qualified, 1280 cmpds per plate, first four and last four columns empty

Item

2

Catalog ID

DDS-50-Z-10

Compounds

50 240

Plates

40

Amount

10 µL of 10 mM DMSO stock solutions

Plates and format

1536-well microplates, Echo Qualified, 1280 cmpds per plate, first four and last four columns empty

Item

3

Catalog ID

DDS-50-Y-25

Compounds

50 240

Plates

143

Amount

25 µL of 10 mM
DMSO stock solutions

Plates and format

384-well acoustic plates, Labcyte PP0200, last two columns empty, 352 cmpds per plate

Item

4

Catalog ID

DDS-50-Y-50

Compounds

50 240

Plates

157

Amount

50 µL of 10 mM
DMSO stock solutions

Plates and format

384-well standard plates, first two and last two columns empty, 320 cmpds per plate

The hits discovered from Discovery Diversity Sets are expected to easily yield lead compounds. All identified hits can be readily followed with analogues either from stock or from new syntheses through our REAL database technology. All building blocks for lead optimization programs are readily available from Enamine stock.

Key features

  • Novel compounds
  • No singletons, 3-5 compounds per cluster
  • 4 912 Bemis-Murcko frameworks (DDS 50)
  • No PAINS, only medchem friendly compounds
  • Express follow-up guaranteed

Comparative analysis of DDSs and commercially available compounds

74% of the compounds from DDS 50K are available exclusively at Enamine

Reference database of 16.8M commercially available compounds from 33 vendors were collected from Zinc and eMolecules.

Examples of the molecules

Z1885611703

Z1885611703
MW 358
ClogP 1.89

Z2017826378

Z2017826378
MW 302
ClogP 1.38

Z2060539340

Z2060539340
MW 307
ClogP 0.43

Z1647886734

Z1647886734
MW 273
ClogP 2.43

Z1683527071

Z1683527071
MW 298
ClogP 2.19

Z1640823403

Z1640823403
MW 325
ClogP 2.78

Z2054188929

Z2054188929
MW 342
ClogP 1.5

Z1727361122

Z1727361122
MW 275
ClogP 1.10

Z1461770453

Z1461770453
MW 338
ClogP 1.97

Z1846299521

Z1846299521
MW 316
ClogP 2.02

Z1265264308

Z1265264308
MW 346
ClogP 2.93

Z2053432847

Z2053432847
MW 261
ClogP 0.51

Z30996552

Z30996552
MW 362
ClogP 2.99

Z1850142310

Z1850142310
MW 301
ClogP 1.73

Molecular properties

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