Discovery Diversity Set
High-quality diverse library of latest compounds
10 240 compounds
The success of high throughput screening in finding decent starting points for drug discovery heavily depends on the quality of the compound library. Compound screening libraries nowadays must bear an essential degree of novelty, possess contemporary lead-like properties and be built on “live” chemistry that can supply related chemical entities.
Only within last three years Enamine synthesized over 450 000 screening compounds for its public catalog. These substances feature a new structural diversity of Enamine unique building blocks and scaffolds. Having the largest commercial screening collection in the world, Enamine remains the only library producer that keeps enhancing its collection with significant number of new compounds each year. The renowned quality of compounds has been distilled in the design of two Discovery Diversity Sets (DDS). Discovery Diversity Sets are based only on the lead-like compounds including representatives of all three screening collections of Enamine – HTS, Advanced, and Premium.
The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because of diversity of scaffolds and presence of latest building blocks.
Discovery Diversity Sets have been plated at 10 mM concentration in DMSO and can be swiftly supplied in different customized formats including following most popular options:
Typical Formats
Catalog No.
DDS-10-0-Z-0
Compounds
10 240
8 plates
Amount
≤ 150 nL of DMSO solutions
Plates and formats
1536-well echo-qualified assay ready microplates, Labcyte LP0400
Price
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Catalog No.
DDS-10-10-Y-10
Compounds
10 240
32 plates
Amount
10 µL of 10 mM of DMSO solutions
Plates and formats
384-well acoustic plates, Labcyte LP0200,
first and last columns empty,
320 compounds per plate
Price
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Catalog No.
DDS-10-50-X-10
Compounds
10 240
128 plates
Amount
50 µL of 10 mM of DMSO solutions
Plates and formats
96-well plates, Greiner Cat. No 650201, round (U) bottom,
1 & 12 columns empty,
80 compounds per plate
Price
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Catalog No.
DDS-10
Compounds
10 240
Amount
Custom
Plates and formats
Any custom format
Price
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The hits discovered from Discovery Diversity Sets are expected to easily yield lead compounds. All identified hits can be readily followed with analogues either from stock or from new syntheses through our REAL database technology. All building blocks for lead optimization programs are readily available from Enamine stock.
Key features
- Novel compounds
- No singletons, 3-5 compounds per cluster
- 3 050 clusters within BMS frameworks (DDS-10)
- No PAINS, only medchem friendly compounds
- Express follow-up guaranteed
Comparative analysis of DDSs and commercially available compounds

74% of the compounds from DDS 10K are available exclusively at Enamine
Reference database of 16.8M commercially available compounds from 33 vendors were collected from Zinc and eMolecules.
Examples of the molecules

Z2392371483
MW 320
ClogP 0.17

Z1757113034
MW 291
ClogP -0.23

Z2054572371
MW 340
ClogP 0.28

Z3132959718
MW 300
ClogP 1.25

Z3063546889
MW 281
ClogP 0.70

Z2053973853
MW 356
ClogP 1.2

Z2608163519
MW 391
ClogP 1.80

Z2761561535
MW 326
ClogP 0.68
Molecular properties





