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Discovery Diversity Set

High-quality diverse library of latest compounds

10 240 compounds

The success of high throughput screening in finding decent starting points for drug discovery heavily depends on the quality of the compound library. Compound screening libraries nowadays must bear an essential degree of novelty, possess contemporary lead-like properties and be built on “live” chemistry that can supply related chemical entities.

Only within last three years Enamine synthesized over 450 000 screening compounds for its public catalogue. These substances feature a new structural diversity of Enamine unique building blocks and scaffolds. Having the largest commercial screening collection in the world, Enamine remains the only library producer that keeps enhancing its collection with significant number of new compounds each year. The renowned quality of compounds has been distilled in the design of two Discovery Diversity Sets (DDS). Discovery Diversity Sets are based only on the lead-like compounds including representatives of all three screening collections of Enamine – HTS, Advanced, and Premium.

The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because of diversity of scaffolds and presence of latest building blocks.

Discovery Diversity Sets have been plated at 10 mM concentration in DMSO and can be swiftly supplied in different customized formats including following most popular options:

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

DDS-10-Z-0

Compounds

10 240
8 plates

Amount

Assay-ready, ≤ 150 nL of DMSO solutions

Plates and formats

1536-well echo-qualified assay ready microplates, Labcyte LP0400

Catalog No.

DDS-10-Y-10

Compounds

10 240
32 plates

Amount

10 µL of 10 mM of DMSO stock solutions

Plates and formats

384-well acoustic plates, Labcyte LP0200, first and last columns empty, 320 compounds per plate

Catalog No.

DDS-10-Y-25

Compounds

10 240
32 plates

Amount

25 µL of 10 mM of DMSO stock solutions

Plates and formats

384-well standard microplate Greiner, first and last columns empty, 320 compounds per plate

Catalog No.

DDS-10-X-50

Compounds

10 240
128 plates

Amount

50 µL of 10 mM of DMSO stock solutions

Plates and formats

96-well plates, Greiner Cat. No 650201, round (U) bottom, 80 compounds per plate, 1 & 12 columns empty

Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

Get more details

The hits discovered from Discovery Diversity Sets are expected to easily yield lead compounds. All identified hits can be readily followed with analogues either from stock or from new syntheses through our REAL database technology. All building blocks for lead optimization programs are readily available from Enamine stock.

Key features

  • Novel compounds
  • No singletons, 3-5 compounds per cluster
  • 3 050 clusters within BMS frameworks (DDS-10)
  • No PAINS, only medchem friendly compounds
  • Express follow-up guaranteed

Comparative analysis of DDSs and commercially available compounds

74% of the compounds from DDS 10K are available exclusively at Enamine

Reference database of 16.8M commercially available compounds from 33 vendors were collected from Zinc and eMolecules.

Examples of the molecules

Z2392371483

Z2392371483
MW 320
ClogP 0.17

Z1757113034

Z1757113034
MW 291
ClogP -0.23

Z2054572371

Z2054572371
MW 340
ClogP 0.28

Z3132959718

Z3132959718
MW 300
ClogP 1.25

Z3063546889

Z3063546889
MW 281
ClogP 0.70

Z2053973853

Z2053973853
MW 356
ClogP 1.2

Z2608163519

Z2608163519
MW 391
ClogP 1.80

Z2761561535

Z2761561535
MW 326
ClogP 0.68

Molecular properties

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