A Subset of Enamine REAL Compounds, Valuable Addition to The REAL/xREAL Space
Enamine unREAL® Space is a new, original extension to Enamine REAL compounds.
This collection is broad and diverse, opening a much larger access to synthetically accessible chemical space for drug discovery. All compounds from the unREAL Space are available in the shortest possible time thanks to well-established and validated synthesis protocols. The unREAL Compounds are assembled using 24 unique, well-validated synthetic protocols not included in the REAL/xREAL Space.
Key Facts
- Over 70.9B new, unique compounds that complement the REAL/xREAL Space
- Over 38B compounds compliant with Ro5, and over 33B compounds compliant with Veber's rule
- Shipping from 4 weeks
- Over 80% of compounds delivered
- All compounds undergo extensive quality control by 1H NMR and LC-MS, and purity is guaranteed to be over 90%.
Applications
- Hit finding
- SAR and hit-to-lead
- Compound library extension
Novelty
The unREAL Compounds are an innovative dataset of screening compounds that unlocks access to billions of previously unknown, unique structures. Enamine specialists continuously develop new and original building blocks, expanding access to an infinite chemical space for drug discovery. In most cases, Enamine provides the ability to supply these compounds without publishing them in their in-stock catalogs and online databases (Reaxys, SciFinder, Pubchem, etc.).
Diversity
The unREAL Space is built on 620 million Bemis-Murcko scaffolds that are unique and not present in the REAL/xREAL Space. This incredible diversity of scaffolds is made possible by utilizing over 86,700 unique building blocks assembled via 24 synthetic protocols.
Accessibility
The unREAL Space and its subsets are available upon request. Please send us an inquiry to
VHL binders and their functionalized analogs
The VHL E3 ligase, a member of the Cullin-RING E3 ubiquitin ligase family, is responsible for the ubiquitination and subsequent proteasomal degradation of specific substrates, including HIF-α. PROTACs, heterobifunctional molecules, exploit this cellular machinery by recruiting target proteins to the E3 ligase, leading to their ubiquitination and degradation. The development of effective PROTACs relies on the availability of high-affinity small-molecule ligands that can bind to E3 ligases with high specificity.
With years of experience in VHL chemistry, our team has a deep understanding of this field. Our chemists continuously innovate, designing and synthesizing novel Building Blocks and exploring creative modifications of key intermediates. Leveraging this expertise, we’ve enumerated a REAL space of over million VHL-targeted compounds, which can be rapidly synthesized within 4 weeks with an impressive 80% success rate. Also, we are offering ready-to-use VHL ligand-linkers conjugate kits – sets with well-balanced linkers and common VHL binders to support your discoveries.
Examples of in-stock VHL binders
Selected publications
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Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders.
Diehl C., Ciulli A. Chem. Soc. Rev. 2022, 51, 8216. DOI: 10.1039/D2CS00387B
Includes 3 sets
Examples of Enamine Basicity-Tuning Cyclobutylamine Kits
Basic set
Catalog No.
Basic set-50
Compounds
7
Amount
50 mg
Price
Catalog No.
Basic set-100
Compounds
7
Amount
100 mg
Price
Catalog No.
Basic set-500
Compounds
7
Amount
500 mg
Price
Advanced set
Catalog No.
Advanced set-50
Compounds
7
Amount
50 mg
Price
Catalog No.
Advanced set-100
Compounds
7
Amount
100 mg
Price
Catalog No.
Advanced set-500
Compounds
7
Amount
500 mg
Price
Pro set
Catalog No.
Pro set-50
Compounds
15
Amount
50 mg
Price
Catalog No.
Pro set-100
Compounds
15
Amount
100 mg
Price
Catalog No.
Pro set-500
Compounds
15
Amount
500 mg
Price
Includes 3 sets
Examples of Enamine Basicity-Tuning Cyclopropylamine Kits
Basic set
Catalog No.
Basic set-50
Compounds
7
Amount
50 mg
Price
Catalog No.
Basic set-100
Compounds
7
Amount
100 mg
Price
Catalog No.
Basic set-500
Compounds
7
Amount
500 mg
Price
Advanced set
Catalog No.
Advanced set-50
Compounds
7
Amount
50 mg
Price
Catalog No.
Advanced set-100
Compounds
7
Amount
100 mg
Price
Catalog No.
Advanced set-500
Compounds
7
Amount
500 mg
Price
Pro set
Catalog No.
Pro set-50
Compounds
15
Amount
50 mg
Price
Catalog No.
Pro set-100
Compounds
15
Amount
100 mg
Price
Catalog No.
Pro set-500
Compounds
15
Amount
500 mg
Price
Includes 3 sets
Examples of Enamine Basicity-Tuning Morpholine Kits
Basic set
Catalog No.
Basic set-50
Compounds
7
Amount
50 mg
Price
Catalog No.
Basic set-100
Compounds
7
Amount
100 mg
Price
Catalog No.
Basic set-500
Compounds
7
Amount
500 mg
Price
Advanced set
Catalog No.
Advanced set-50
Compounds
7
Amount
50 mg
Price
Catalog No.
Advanced set-100
Compounds
7
Amount
100 mg
Price
Catalog No.
Advanced set-500
Compounds
7
Amount
500 mg
Price
Pro set
Catalog No.
Pro set-50
Compounds
15
Amount
50 mg
Price
Catalog No.
Pro set-100
Compounds
15
Amount
100 mg
Price
Catalog No.
Pro set-500
Compounds
15
Amount
500 mg
Price