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Synthesis of 5-hydroxy- and 5-sulfanyl-substituted [1,2,3]triazolo[4,5-е][1,4]diazepines

Chem. Heterocycl. Compd. 2018, 54 (8), 789-795

DOI: 10.1007/s10593-018-2350-7

Kemskiy S.; Syrota N.; Bol’but A.; Dorokhov V.; Vovk M.

5-Amino-N-(2,2-dimethoxyethyl)-1Н-1,2,3-triazole-4-carboxamides in formic acid were subjected to intramolecular cyclization to 5-hydroxy[1,2,3]triazolo[4,5-е][1,4]diazepines, which were converted by treatment with S-nucleophiles to 5-thio-functionalized derivatives.

Synthesis of 5-hydroxy- and 5-sulfanyl-substituted [1,2,3]triazolo[4,5-е][1,4]diazepines

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