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  • Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

RSC Adv. 2018, 8 (10), 5114-5118

DOI: 10.1039/C7RA13141K

Zheng Y.; Yu X.; Lv S.; Mykhailiuk P.; Ma Q.; Hai L.; Wu Y.

A practical synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes was developed for the first time. The key step was photochemical decomposition of CHF2-substituted pyrazolines. This protocol has the advantages of simple operation, and mild conditions, as well as excellent functional group tolerance, giving the desired products in moderate to excellent yields.

Synthesis of CHF<sub>2</sub>-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF<sub>2</sub>-pyrazolines

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