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Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides

Chem. Eur. J. 2018, 24 (33), 8343-8349

DOI: 10.1002/chem.201801140

Zhersh S.; Blahun O.; Sadkova I.; Tolmachev A.; Moroz Y.; Mykhailiuk P.

Cyclic saturated amino sulfonyl fluorides were synthesized as HCl‐salts. The compounds were stable upon storage and could be used for the protecting‐group free synthesis of sulfonamides. In the presence of the ‐SO2F group, the nitrogen atom can be modified by means of acylation, arylation, and reductive amination, that has a high potential for the synthesis of bioactive compounds.

Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides

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