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Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde

Mol. Diver. 2016, 20 (1), 1-7

DOI: 10.1007/s11030-015-9633-z

Sokolyuk P. A.; Kondratov I. S.; Gavrylenko O. V.; Tolmachov A. A.

A series of pyrazole-4-sulfonyl chlorides was obtained by a convenient 2-step method starting from synthetically available 2-(benzylthio)malonaldehyde. The method can be applied for the effective multi-gram synthesis of diverse pyrazole-containing sulfonyl chlorides which are mostly not available by other methods.

Synthesis of diverse pyrazole-4-sulfonyl chlorides starting from 2-(benzylthio)malonaldehyde

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