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Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom

Org. Lett. 2016, 18 (14), 3406-3409

DOI: 10.1021/acs.orglett.6b01565

Arkhipov A. V.; Arkhipov V. V.; Cossy J.; Kovtunenko V. O.; Mykhailiuk P. K.

After more than 70 years since its discovery, CF3CHN2 was found to possess a novel reactivity mode: N-terminal electrophile. With C-nucleophiles it gives hydrazones that are easily transformed into valuable CF3-heterocycles.

Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom

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