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Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes

Org. Biomol. Chem. 2015, 13 (11), 3438-3445

DOI: 10.1039/C4OB02670E

Mykhailiuk P. K.

Three-component reaction between RCF2CH2NH2•HCl, NaNO2 and electron-deficient alkynes significantly depends on substituent "R". The reaction gives the fluorinated pyrazoles in high yields when "R" is a fluorine atom or a fluoroalkyl group. With other "R" unexpected products are formed.

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes

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