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Facile one-pot synthesis of 4-substituted semicarbazides

RSC Adv. 2015, 5 (2), 1063-1069

DOI: 10.1039/C4RA12425A

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Dmytriv Y. V.; Pipko S. E.; Babichenko L. N.; Konovets A. I.; Tolmachev A.

A diverse library of twenty-five 4-mono- and disubstituted semicarbazides was prepared in a one-pot two-step approach. The method includes formation of a carbamate from bis(2,2,2-trifluoroethyl)carbonate or 2,2,2-trifluoroethylchloroformate and a primary or secondary amine and subsequent interaction of the carbamate with hydrazine to result in a semicarbazide. The approach allowed to obtain 4-substituted semicarbazides on a large scale in good yield and high purity.

Facile one-pot synthesis of 4-substituted semicarbazides

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