Design and Synthesis of Novel 19F-Amino Acid: A Promising 19F NMR Label for Peptide Studies
Org. Lett. 2015, 17 (2), 226-229
Novel aliphatic 19F-substituted amino acid was designed as a 19F NMR label for peptide studies. The synthesis was performed in 11 steps and 9% overall yield from a commercially available starting material. The key transformation was a decarboxylative fluorination of an aliphatic carboxylic acid with XeF2 in C6F6.