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Design and Synthesis of Novel 19F-Amino Acid: A Promising 19F NMR Label for Peptide Studies

Org. Lett. 2015, 17 (2), 226-229

DOI: 10.1021/ol503300m

Bandak D.; Babii O.; Vasiuta R.; Komarov I. V.; Mykhailiuk P. K.

Novel aliphatic 19F-substituted amino acid was designed as a 19F NMR label for peptide studies. The synthesis was performed in 11 steps and 9% overall yield from a commercially available starting material. The key transformation was a decarboxylative fluorination of an aliphatic carboxylic acid with XeF2 in C6F6.

Design and Synthesis of Novel 19F-Amino Acid: A Promising 19F NMR Label for Peptide Studies

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