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A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

ACS Comb. Sci. , 2014, 16 (8), 375-380

DOI: 10.1021/co5000568

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Panov D. M.; Pipko S. E.; Konovets A. I.; Tolmachev A.

A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.

A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Panov D. M.; Pipko S. E.; Konovets A. I.; Tolmachev A.
ACS Comb. Sci. 2014, 16 (8), 375-380
DOI: 10.1021/co5000568

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