Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines
Eur. J. Org. Chem. , 2013, 15, 3086-3093
A practical synthetic approach to the construction of a library of three isomeric/homologous β-trifluoromethyl-substituted pyrrolidines is disclosed. All products were prepared in multigram quantities from a common precursor. The key synthetic step was a [3+2] cycloaddition reaction. The influence of the trifluoromethyl group on the physicochemical characteristics of the pyrrolidine fragment was studied.
Yarmolchuk V. S.; Shishkin O. V.; Starova V. S.; Zaporozhets O. A.; Kravchuk O.; Zozulya S.; Komarov I. V.; Mykhailiuk P. K.
Eur. J. Org. Chem. 2013, 15, 3086-3093