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1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization

Tetrahedron , 2013, 69 (20), 4066-4075

DOI: 10.1016/j.tet.2013.03.072

Mykhailiuk P. K.; Starova V.; Iurchenko V.; Shishkina S. V.; Shishkin O. V.; Khilchevskyi O.; Zaporozhets O.

1-Amino-4,4-difluorocyclohexanecarboxylic acid has been designed as a fluorinated analogue of the pharmacologically relevant 1-aminocyclohexanecarboxylic acid. The synthesis has been performed in three steps from a commercially available material in 22% overall yield. An impact of fluorine atoms on conformation, lipophilicity, acidity and fluorescent properties of the amino acid has been studied. Various practical applications of the obtained compound are suggested.

1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization

Mykhailiuk P. K.; Starova V.; Iurchenko V.; Shishkina S. V.; Shishkin O. V.; Khilchevskyi O.; Zaporozhets O.
Tetrahedron 2013, 69 (20), 4066-4075
DOI: 10.1016/j.tet.2013.03.072

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