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Synthesis of Isomeric 6-Trifluoromethyl-3-azabicyclo[3.1.0]hexanes: Conformationally Restricted Analogues of 4-Trifluoromethylpiperidine

Synthesis , 2013, 45 (02), 225-230

DOI: 10.1055/s-0032-1316831

Artamonov O. S.; Slobodyanyuk E. Y.; Shishkin O. V.; Komarov I. V.; Mykhailiuk P. K.

Two isomeric conformationally restricted analogues of 4-trifluoromethylpiperidine were designed. The synthesis was performed in four steps from commercially available N-benzylmaleimide. The key reaction was the [3+2] cycloaddition between trifluoromethyldiazomethane and N-benzylmaleimide.

Synthesis of Isomeric 6-Trifluoromethyl-3-azabicyclo[3.1.0]hexanes: Conformationally Restricted Analogues of 4-Trifluoromethylpiperidine

Artamonov O. S.; Slobodyanyuk E. Y.; Shishkin O. V.; Komarov I. V.; Mykhailiuk P. K.
Synthesis 2013, 45 (02), 225-230
DOI: 10.1055/s-0032-1316831

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