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Synthesis of a novel Boc-protected cyclopropane-modified proline analogue

Tetrahedron Lett. , 2012, 53 (30), 3847-3849

DOI: 10.1016/j.tetlet.2012.05.020

Tymtsunik A. V.; Bilenko V. A.; Ivon Y. M.; Grygorenko O. O.; Komarov I. V.

The synthesis of the Boc derivative of a novel member of the cyclopropane-modified proline library, Boc-protected 5-azaspiro[2.4]heptane-6-carboxylic acid, is reported. The synthesis was performed in six steps starting from (2S,4R)-4-hydroxyproline using a modified Simmons–Smith reaction as the key step. The reaction conditions for all the steps were carefully selected to avoid racemization at the chiral centers in the intermediates and the final product.

Synthesis of a novel Boc-protected cyclopropane-modified proline analogue

Tymtsunik A. V.; Bilenko V. A.; Ivon Y. M.; Grygorenko O. O.; Komarov I. V.
Tetrahedron Lett. 2012, 53 (30), 3847-3849
DOI: 10.1016/j.tetlet.2012.05.020

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